Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

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Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3

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The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

(2019) Matthew G. Oser et al.   GENES & DEVELOPMENT

MLL2 promotes cancer cell lymph node metastasis by interacting with RelA and facilitating STC1 transcription

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Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

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Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

(2018) Guiju Tang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma

(2018) Abulajiang Abudureheman et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer

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Progress in the application and mechanism of metformin in treating non-small cell lung cancer

(2017) Chan Li et al.   Oncology Letters

Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells

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Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer

(2017) Sang-Won Um et al.   Clinical Epigenetics

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Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

(2016) David Cano-Rodriguez et al.   Nature Communications

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

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Trimmomatic: a flexible trimmer for Illumina sequence data

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Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Retinoblastoma Binding Protein 2 (RBP2) Promotes HIF-1α–VEGF-Induced Angiogenesis of Non-Small Cell Lung Cancer via the Akt Pathway

(2014) Lei Qi et al.   PLoS One

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

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Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells

(2014) YU DU et al.   Oncology Letters

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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The future of epigenetic therapy in solid tumours—lessons from the past

(2013) Nilofer Azad et al.   Nature Reviews Clinical Oncology

RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer

(2013) Shikun Wang et al.   PLoS One

An integrated encyclopedia of DNA elements in the human genome

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MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

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Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

(2010) Thanemozhi G Natarajan et al.   Cancer Cell International

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

(2009) Jiping Zeng et al.   GASTROENTEROLOGY

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

(2008) Ali Shilatifard   CURRENT OPINION IN CELL BIOLOGY

Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

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