Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology
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Title
Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology
Authors
Keywords
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Journal
Cancers
Volume 13, Issue 4, Pages 761
Publisher
MDPI AG
Online
2021-02-13
DOI
10.3390/cancers13040761
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Note: Only part of the references are listed.- cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas
- (2020) Daniel J. Brat et al. ACTA NEUROPATHOLOGICA
- Imaging of intratumoral heterogeneity in high-grade glioma
- (2020) Leland S. Hu et al. CANCER LETTERS
- cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading
- (2020) David N. Louis et al. BRAIN PATHOLOGY
- A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes
- (2020) Francesca Orzan et al. LABORATORY INVESTIGATION
- Immunohistochemically Characterized Intratumoral Heterogeneity Is a Prognostic Marker in Human Glioblastoma
- (2020) Friederike Liesche-Starnecker et al. Cancers
- Development and Validation of a Novel DNA Methylation-Driven Gene Based Molecular Classification and Predictive Model for Overall Survival and Immunotherapy Response in Patients With Glioblastoma: A Multiomic Analysis
- (2020) Zihao Wang et al. Frontiers in Cell and Developmental Biology
- Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
- (2020) Francesca Petralia et al. CELL
- A novel methylation signature predicts radiotherapy sensitivity in glioma
- (2020) Yuemei Feng et al. Scientific Reports
- The Epigenetics of Glioma Stem Cells: A Brief Overview
- (2020) Luis M. Valor et al. Frontiers in Oncology
- Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
- (2019) Jérôme Galon et al. NATURE REVIEWS DRUG DISCOVERY
- Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma
- (2019) Seçkin Akgül et al. Cancers
- A Meta-Analysis of Survival Outcomes Following Reoperation in Recurrent Glioblastoma: Time to Consider the Timing of Reoperation
- (2019) Yu-Hang Zhao et al. Frontiers in Neurology
- Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
- (2019) Timothy F. Cloughesy et al. NATURE MEDICINE
- Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma
- (2019) Kurt A. Schalper et al. NATURE MEDICINE
- Brain Tumor Microenvironment and Host State: Implications for Immunotherapy
- (2019) William Tomaszewski et al. CLINICAL CANCER RESEARCH
- Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis
- (2019) Verena Körber et al. CANCER CELL
- Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas
- (2019) Michael Bockmayr et al. Cancer Immunology Research
- Spatial Distance Correlates With Genetic Distance in Diffuse Glioma
- (2019) Evan D. H. Gates et al. Frontiers in Oncology
- Tumor Heterogeneity in Gliomas – a Histopathology-Targeted Proteomic Pilot Study
- (2019) A. Becker et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Longitudinal molecular trajectories of diffuse glioma in adults
- (2019) Floris P. Barthel et al. NATURE
- PATH-19. TUMOR HETEROGENEITY IN GLIOMAS: A PILOT STUDY OF HISTOPATHOLOGY-ASSOCIATED PROTEOME PROFILES ASSESSED BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY OF FFPE SAMPLES
- (2019) Aline Paixao Becker et al. NEURO-ONCOLOGY
- Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma
- (2019) Lisandra Muñoz-Hidalgo et al. NEOPLASIA
- Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma
- (2018) Rajendra P. Pangeni et al. Epigenetics
- Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
- (2018) Ana C. deCarvalho et al. NATURE GENETICS
- Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells
- (2018) Mara Vinci et al. NATURE MEDICINE
- Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
- (2018) Lukas Bunse et al. NATURE MEDICINE
- Grading of Diffuse Astrocytic Gliomas: A Review of Studies Before and After the Advent of IDH Testing
- (2018) Takahiro Ono et al. SEMINARS IN NEUROLOGY
- Unveiling new interdependencies between significant DNA methylation sites, gene expression profiles and glioma patients survival
- (2018) Michal J. Dabrowski et al. Scientific Reports
- Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma
- (2018) Damian Stichel et al. ACTA NEUROPATHOLOGICA
- The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
- (2018) Johanna Klughammer et al. NATURE MEDICINE
- Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma
- (2017) Roger Stupp et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity
- (2017) Malte Mohme et al. MOLECULAR THERAPY
- Spatiotemporal genomic architecture informs precision oncology in glioblastoma
- (2017) Jin-Ku Lee et al. NATURE GENETICS
- Surgical oncology for gliomas: the state of the art
- (2017) Nader Sanai et al. Nature Reviews Clinical Oncology
- Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas
- (2017) Josie Hayes et al. NEURO-ONCOLOGY
- Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas
- (2017) Khalil Abou-El-Ardat et al. NEURO-ONCOLOGY
- Prognostic value of O-6-methylguanine-DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis
- (2017) R. H. Dahlrot et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Heterogeneity of tumor-infiltrating lymphocytes ascribed to local immune status rather than neoantigens by multi-omics analysis of glioblastoma multiforme
- (2017) Lin Feng et al. Scientific Reports
- Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era
- (2017) Erica Hlavin Bell et al. JAMA Oncology
- Tumor infiltrating immune cells in gliomas and meningiomas
- (2016) Patrícia Domingues et al. BRAIN BEHAVIOR AND IMMUNITY
- ATRX in Diffuse Gliomas With its Mosaic/Heterogeneous Expression in a Subset
- (2016) Suvendu Purkait et al. BRAIN PATHOLOGY
- Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
- (2016) Michele Ceccarelli et al. CELL
- The role of microglia and macrophages in glioma maintenance and progression
- (2016) Dolores Hambardzumyan et al. NATURE NEUROSCIENCE
- Radiogenomics to characterize regional genetic heterogeneity in glioblastoma
- (2016) Leland S. Hu et al. NEURO-ONCOLOGY
- Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
- (2016) Lindsey M. Hoffman et al. Acta Neuropathologica Communications
- A Time-Based and Intratumoral Proteomic Assessment of a Recurrent Glioblastoma Multiforme
- (2016) Priscila F. de Aquino et al. Frontiers in Oncology
- Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images
- (2016) Rika Inano et al. Scientific Reports
- Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma
- (2015) Qun Liu et al. ACTA NEUROPATHOLOGICA
- Bioanalytical chemistry of cytokines – A review
- (2015) Julie A. Stenken et al. ANALYTICA CHIMICA ACTA
- DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors
- (2015) Tali Mazor et al. CANCER CELL
- Mutational landscape and clonal architecture in grade II and III gliomas
- (2015) Hiromichi Suzuki et al. NATURE GENETICS
- Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
- (2015) Mona Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- Subclassification of Newly Diagnosed Glioblastomas through an Immunohistochemical Approach
- (2014) Siobhan Conroy et al. PLoS One
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- (2014) A. P. Patel et al. SCIENCE
- Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes
- (2013) Daniel Stieber et al. ACTA NEUROPATHOLOGICA
- The Somatic Genomic Landscape of Glioblastoma
- (2013) Cameron W. Brennan et al. CELL
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome
- (2013) Shadi Lalezari et al. NEURO-ONCOLOGY
- Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
- (2013) A. Sottoriva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MALDI imaging and in-source decay for top-down characterization of glioblastoma
- (2013) Rima Ait-Belkacem et al. PROTEOMICS
- Receptor Tyrosine Kinase Genes Amplified in Glioblastoma Exhibit a Mutual Exclusivity in Variable Proportions Reflective of Individual Tumor Heterogeneity
- (2012) S. E. Little et al. CANCER RESEARCH
- Genomic instability and p53 alterations in patients with malignant glioma
- (2012) Vedrana Milinkovic et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Targeted Tissue Proteomic Analysis of Human Astrocytomas
- (2012) Xueping Fang et al. JOURNAL OF PROTEOME RESEARCH
- Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
- (2011) Matija Snuderl et al. CANCER CELL
- Heterogeneity Maintenance in Glioblastoma: A Social Network
- (2011) R. Bonavia et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Transdifferentiation of glioblastoma cells into vascular endothelial cells
- (2011) Y. Soda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- (2010) Houtan Noushmehr et al. CANCER CELL
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Multifarious proteomic signatures and regional heterogeneity in glioblastomas
- (2009) Chul-Kee Park et al. JOURNAL OF NEURO-ONCOLOGY
- Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
- (2009) Roger Stupp et al. LANCET ONCOLOGY
- Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity
- (2008) Monika E. Hegi et al. JOURNAL OF CLINICAL ONCOLOGY
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
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