Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer

(2020) Joshua M Walker et al.   Journal for ImmunoTherapy of Cancer

Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial

(2020) Federica Cappuccini et al.   Journal for ImmunoTherapy of Cancer

Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer

(2020) Alessio Ugolini et al.   JCI Insight

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

(2020) Stefano Pierini et al.   JCI Insight

T cell engineered with a novel nanobody‐based chimeric antigen receptor against VEGFR2 as a candidate for tumor immunotherapy

(2019) Fatemeh Hajari Taheri et al.   IUBMB LIFE

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

(2019) Sean K. Maynard et al.   BMC CANCER

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

(2019) Mireia Uribe-Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

(2018) Shetal A. Patel et al.   IMMUNITY

Soluble PD-1-based vaccine targeting MUC1 VNTR and survivin improves anti-tumor effect

(2018) Chenlu Liu et al.   IMMUNOLOGY LETTERS

B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction

(2018) Ling Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours

(2018) Amit Maity et al.   BRITISH JOURNAL OF CANCER

Immune recognition of irradiated cancer cells

(2017) Erik Wennerberg et al.   IMMUNOLOGICAL REVIEWS

Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+T Cells

(2017) Bo Xiang et al.   JOURNAL OF IMMUNOLOGY

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

(2017) James L. Gulley et al.   JNCI-Journal of the National Cancer Institute

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Radiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model

(2017) Kyoung-Jin Kim et al.   Oncotarget

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

(2017) James L. Gulley et al.   JNCI-Journal of the National Cancer Institute

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

(2017) Rajeev K. Shrimali et al.   Cancer Immunology Research

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

(2017) Zijun Y. Xu-Monette et al.   Frontiers in Immunology

Trial watch: DNA-based vaccines for oncological indications

(2017) Stefano Pierini et al.   OncoImmunology

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

(2017) Andrea Facciabene et al.   OncoImmunology

Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen

(2017) Gilda G. Hillman et al.   Journal for ImmunoTherapy of Cancer

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

MUC1 and survivin combination tumor gene vaccine generates specific immune responses and anti-tumor effects in a murine melanoma model

(2016) Haihong Zhang et al.   VACCINE

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Targeting tumor vasculature: expanding the potential of DNA cancer vaccines

(2015) Stefano Ugel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Induction of CD4+and CD8+anti-tumor effector T cell responses by bacteria mediated tumor therapy

(2015) Christian Stern et al.   INTERNATIONAL JOURNAL OF CANCER

A Tumor Mitochondria Vaccine Protects against Experimental Renal Cell Carcinoma

(2015) Stefano Pierini et al.   JOURNAL OF IMMUNOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

(2015) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase 1 study of a heterologous prime-boost vaccination involving a truncated HER2 sequence in patients with HER2-expressing breast cancer

(2015) Sung-Bae Kim et al.   Molecular Therapy-Methods & Clinical Development

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature

(2014) John G. Facciponte et al.   JOURNAL OF CLINICAL INVESTIGATION

Prime-Boost Immunization Strategies against Chikungunya Virus

(2014) D. Hallengard et al.   JOURNAL OF VIROLOGY

Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound

(2013) Ahmed El Kaffas et al.   ANGIOGENESIS

Promoter hypermethylation ofCDKN2A,MGMT,MLH1, andDAPKgenes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients

(2013) Stefano Pierini et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer

(2013) E. B. Golden et al.   Cancer Immunology Research

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation-Induced Vascular Damage in Tumors: Implications of Vascular Damage in Ablative Hypofractionated Radiotherapy (SBRT and SRS)

(2012) Heon Joo Park et al.   RADIATION RESEARCH

Role of T lymphocytes in tumor response to radiotherapy

(2012) Sandra Demaria et al.   Frontiers in Oncology

Rapid isolation of high-affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast-display/secretory scFv library platform

(2010) Aizhi Zhao et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Heterologous Prime/Boost Immunization With p53-based Vaccines Combined With Toll-like Receptor Stimulation Enhances Tumor Regression

(2010) Hidenobu Ishizaki et al.   JOURNAL OF IMMUNOTHERAPY

Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials

(2010) Scott A. Brown et al.   Viruses-Basel

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

Radiotherapy Decreases Vascular Density and Causes Hypoxia with Macrophage Aggregation in TRAMP-C1 Prostate Tumors

(2009) F.-H. Chen et al.   CLINICAL CANCER RESEARCH

Immunogenicity and safety profiles of genetic vaccines against human Her-2/neu in cynomolgus monkeys

(2008) H-J Ko et al.   GENE THERAPY