Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

(2019) Kelsey Pinkham et al.   Stem Cell Reports

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Similarity regression predicts evolution of transcription factor sequence specificity

(2019) Samuel A. Lambert et al.   NATURE GENETICS

AMP kinase promotes glioblastoma bioenergetics and tumour growth

(2018) Rishi Raj Chhipa et al.   NATURE CELL BIOLOGY

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

(2018) John B. Harley et al.   NATURE GENETICS

Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors

(2016) Yoshikazu Uto   CHEMISTRY AND PHYSICS OF LIPIDS

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Selective DNA methylation in cancers controls collateral damage induced by large structural variations

(2016) Vakul Mohanty et al.   Oncotarget

A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes

(2016) Juli D. Uhl et al.   PLoS Genetics

Driver and Passenger Mutations in Cancer

(2015) Julia R. Pon et al.   Annual Review of Pathology-Mechanisms of Disease

Bovine Brain Region-Specific Stearoyl-CoA Desaturase Expression and Fatty Acid Composition

(2015) A. J. Lengi et al.   LIPIDS

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

(2014) Matthew T. Weirauch et al.   CELL

Therapeutic Targeting of Cancers with Loss of PTEN Function

(2014) Lloye Dillon et al.   CURRENT DRUG TARGETS

Pan-cancer patterns of DNA methylation

(2014) Tania Witte et al.   Genome Medicine

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Human Breast Cancer Tissues Contain Abundant Phosphatidylcholine(36∶1) with High Stearoyl-CoA Desaturase-1 Expression

(2013) Yoshimi Ide et al.   PLoS One

Impact of deleterious passenger mutations on cancer progression

(2013) C. D. McFarland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes

(2013) Xiaoyun Wu et al.   Biomed Research International

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

The Therapeutic Management of Bleeding and Thrombotic Disorders Complicating CNS Malignancies

(2012) Roy E. Strowd et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

(2012) Zhen Shao et al.   GENOME BIOLOGY

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

(2011) U. V. Roongta et al.   MOLECULAR CANCER RESEARCH

Hormonal and nutritional regulation of SCD1 gene expression

(2010) Daniel Mauvoisin et al.   BIOCHIMIE

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements

(2010) Juli D. Uhl et al.   DEVELOPMENTAL BIOLOGY

Lower SCD expression in dendritic cells compared to macrophages leads to membrane lipids with less mono-unsaturated fatty acids

(2010) Josef Ecker et al.   IMMUNOBIOLOGY

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Inhibition of Stearoyl-CoA Desaturase 1 Expression Induces CHOP-Dependent Cell Death in Human Cancer Cells

(2010) Mélaine Minville-Walz et al.   PLoS One

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

CTCF: Master Weaver of the Genome

(2009) Jennifer E. Phillips et al.   CELL

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

(2008) Matthew T Flowers et al.   CURRENT OPINION IN LIPIDOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet

(2008) Matthew T. Flowers et al.   PHYSIOLOGICAL GENOMICS