Phlorotannins: A review on biosynthesis, chemistry and bioactivity

Effects of alternative feed additives to medicinal zinc oxide on productivity, diarrhoea incidence and gut development in weaned piglets

(2020) G. D. Satessa et al.   Animal

The cytotoxic activity of extracts of the brown alga Cystoseira tamariscifolia (Hudson) Papenfuss, against cancer cell lines changes seasonally

(2020) Ahmad A. Mansur et al.   JOURNAL OF APPLIED PHYCOLOGY

Polyphenols from Brown Seaweeds as a Potential Antimicrobial Agent in Animal Feeds

(2020) Lauren Ford et al.   ACS Omega

In vitro multifunctionality of phlorotannin extracts from edible Fucus species on targets underpinning neurodegeneration

(2020) Mariana Barbosa et al.   FOOD CHEMISTRY

Dereplication by High-Performance Liquid Chromatography (HPLC) with Quadrupole-Time-of-Flight Mass Spectroscopy (qTOF-MS) and Antiviral Activities of Phlorotannins from Ecklonia cava

(2019) Hyo Cho et al.   Marine Drugs

Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from Ecklonia cava—An In Vitro and in Silico Study

(2019) Jinhyuk Lee et al.   Marine Drugs

Bioprospecting of brown seaweeds for biotechnological applications: Phlorotannin actions in inflammation and allergy network

(2019) Mariana Barbosa et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Dieckol inhibits non‐small–cell lung cancer cell proliferation and migration by regulating the PI3K/AKT signaling pathway

(2019) Chun‐Hong Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds

(2019) Lauren Ford et al.   PHYTOCHEMICAL ANALYSIS

Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion

(2019) Young-Ju Lee et al.   JOURNAL OF APPLIED PHYCOLOGY

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

(2019) Franco et al.   Antioxidants

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β

(2018) Jialing Wang et al.   ACS Chemical Neuroscience

Phlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERK-CREB-BDNF pathway

(2018) Min Young Um et al.   Journal of Functional Foods

Profiling phlorotannins from Fucus spp. of the Northern Portuguese coastline: Chemical approach by HPLC-DAD-ESI/MS n and UPLC-ESI-QTOF/MS

(2018) Graciliana Lopes et al.   Algal Research-Biomass Biofuels and Bioproducts

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

(2018) Seungeun Lee et al.   Marine Drugs

In Vitro Antibacterial Activity of Phlorotannins from Edible Brown Algae, Eisenia bicyclis Against Streptomycin-Resistant Listeria monocytogenes

(2017) Hyo-Jung Kim et al.   INDIAN JOURNAL OF MICROBIOLOGY

Fucofuroeckol-A from edible marine alga Eisenia bicyclis to restore antifungal activity of fluconazole against fluconazole-resistant Candida albicans

(2017) Ki-Hyun Kim et al.   JOURNAL OF APPLIED PHYCOLOGY

Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell

(2017) Yajing Li et al.   Marine Drugs

A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice

(2017) Hyun-Ah Lee et al.   PHARMACEUTICAL BIOLOGY

Antioxidant properties of phlorotannins from brown seaweed Cystoseira trinodis (Forsskål) C. Agardh

(2017) R. Sathya et al.   Arabian Journal of Chemistry

Maternally offered seaweed extracts improves the performance and health status of the postweaned pig1

(2016) J. Draper et al.   JOURNAL OF ANIMAL SCIENCE

Antibacterial Derivatives of Marine Algae: An Overview of Pharmacological Mechanisms and Applications

(2016) Emer Shannon et al.   Marine Drugs

Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells

(2016) Seung-Hyun Jeong et al.   Molecular Medicine Reports

A marine algal polyphenol, dieckol, attenuates blood glucose levels by Akt pathway in alloxan induced hyperglycemia zebrafish model

(2016) Eun-A Kim et al.   RSC Advances

Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice

(2015) Han-Nui You et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Damage to the Membrane Permeability and Cell Death ofVibrio parahaemolyticusCaused by Phlorotannins with Low Molecular Weight fromSargassum thunbergii

(2015) Yuxi Wei et al.   Journal of Aquatic Food Product Technology

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration

(2015) Eun-Kyung Kim et al.   Marine Drugs

Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy fromEcklonia cava

(2015) Byoung Wook Choi et al.   PHYTOTHERAPY RESEARCH

In vitro antiviral activity of dieckol and phlorofucofuroeckol-A isolated from edible brown alga Eisenia bicyclis against murine norovirus

(2015) Sung-Hwan Eom et al.   ALGAE

Antibacterial activity of the phlorotannins dieckol and phlorofucofuroeckol-A from Ecklonia cava against Propionibacterium acnes

(2015) Jae-Suk Choi et al.   Botanical Sciences

The mechanism of antibacterial activity of phlorofucofuroeckol-A against methicillin-resistant Staphylococcus aureus

(2014) Sung-Hwan Eom et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis

(2014) Jae Sue Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Seamustard (<i>Undaria pinnatifida</i>) Improves Growth, Immunity, Fatty Acid Profile and Reduces Cholesterol in Hanwoo Steers

(2014) J. A. Hwang et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition

(2014) Rae-Kwon Kim et al.   CANCER SCIENCE

8,8′-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages

(2014) Yeong-In Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth

(2014) Ji-Hye Ahn et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cytoprotective Effect of Eckol Against Oxidative Stress-Induced Mitochondrial Dysfunction: Involvement of the FoxO3a/AMPK Pathway

(2014) Areum Daseul Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

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(2014) Kang-Woong Kim et al.   Turkish Journal of Fisheries and Aquatic Sciences

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

(2014) Jeong-Ha Lee et al.   ALGAE

Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava

(2013) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination

(2013) Hyung-Jun Kwon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages

(2013) Hyun Ah Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Preparation and Chromatographic Analysis of Phlorotannins

(2013) José Hipólito Isaza Martínez et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Antioxidant Activity of Various Solvent Fractions from Edible Brown Alga,Eisenia bicyclisand Its Active Compounds

(2013) Tae-Hyung Kwon et al.   JOURNAL OF FOOD SCIENCE

Isolation and Structural Determination of Two Novel Phlorotannins from the Brown Alga Ecklonia kurome Okamura, and Their Radical Scavenging Activities

(2013) Mari Yotsu-Yamashita et al.   Marine Drugs

Structure/Function Analysis of a Type III Polyketide Synthase in the Brown Alga Ectocarpus siliculosus Reveals a Biochemical Pathway in Phlorotannin Monomer Biosynthesis

(2013) L. Meslet-Cladiere et al.   PLANT CELL

Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells

(2012) Bo Ra Ahn et al.   ARCHIVES OF PHARMACAL RESEARCH

Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells

(2012) Seung-Hong Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells

(2012) Sung-Myung Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Antimicrobial effect of phlorotannins from marine brown algae

(2012) Sung-Hwan Eom et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus

(2012) Seung-Hong Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

(2012) Min-Cheol Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetylcholinesterase inhibitory activity of phlorotannins isolated from the brown alga, Ecklonia maxima (Osbeck) Papenfuss

(2012) Rengasamy R.R. Kannan et al.   FOOD RESEARCH INTERNATIONAL

6,6′-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE2 production and inflammatory cytokine expression in macrophages: The inhibition of NFκB

(2012) Yeong-In Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tacrine-Treated HepG2 Cells

(2012) Min-Sup Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant Capacities of Phlorotannins Extracted from the Brown Algae Fucus vesiculosus

(2012) Tao Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory Activities of an Ethanol Extract of Ecklonia stolonifera in Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophage Cells

(2012) Min-Sup Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties

(2012) Federico Ferreres et al.   Marine Drugs

Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling

(2012) Sun Joo Park et al.   MOLECULES AND CELLS

Profiling Phlorotannins in Brown Macroalgae by Liquid Chromatography-High Resolution Mass Spectrometry

(2012) Aaron J. Steevensz et al.   PHYTOCHEMICAL ANALYSIS

In VitroAntibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated fromEisenia bicyclisAgainst Methicillin-ResistantStaphylococcus aureus

(2012) Sung-Hwan Eom et al.   PHYTOTHERAPY RESEARCH

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

(2011) Hye Eun MOON et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Dieckol fromEcklonia cavaRegulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway

(2011) Chen Zhang et al.   Evidence-based Complementary and Alternative Medicine

Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo

(2011) Marie-Claude Roy et al.   FOOD RESEARCH INTERNATIONAL

Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells

(2011) Kyung-Hwan Hyun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The effects of lactose inclusion and seaweed extract derived from Laminaria spp. on performance, digestibility of diet components and microbial populations in newly weaned pigs

(2010) J.V. O’Doherty et al.   ANIMAL FEED SCIENCE AND TECHNOLOGY

Effect of dietary addition of seaweed and licorice on the immune performance of pigs

(2010) Masafumi KATAYAMA et al.   ANIMAL SCIENCE JOURNAL

Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits

(2010) Isuru Wijesekara et al.   BIOFACTORS

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database

(2010) J Pérez-Jiménez et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice

(2010) Seung-Hong Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Synergistic effect between dieckol from Ecklonia stolonifera and β-lactams against methicillin-resistant Staphylococcus aureus

(2009) Dae-Sung Lee et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice

(2009) Soo-Jin Heo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells

(2009) Chang-Suk Kong et al.   FOOD AND CHEMICAL TOXICOLOGY

Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways

(2009) Changkeun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Radical Scavenging and Hyaluronidase Inhibitory Activities of Phlorotannins from the Edible Brown Alga Eisenia arborea

(2009) Yoshimasa SUGIURA et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Antibacterial Activity of Ecklonia cava Against Methicillin-Resistant Staphylococcus aureus and Salmonella spp.

(2009) Jang-Gi Choi et al.   Foodborne Pathogens and Disease

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt

(2009) Ki Cheon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Isolation and Identification of Phlorotannins fromEcklonia stoloniferawith Antioxidant and Anti-inflammatory Properties

(2009) A-Reum Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells

(2009) Won-Kyo Jung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga,Ecklonia cava

(2009) Sang-Hoon Lee et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Phlorotannins from Ishige okamurae and their acetyl- and butyrylcholinesterase inhibitory effects

(2009) Na Young Yoon et al.   Journal of Functional Foods

Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava

(2008) Murat Artan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

(2008) Na Y YOON et al.   FISHERIES SCIENCE