Review
Nutrition & Dietetics
Vito Leonardo Miniello, Andrea Miniello, Laura Ficele, Aleksandra Skublewska-D'Elia, Vanessa Nadia Dargenio, Fernanda Cristofori, Ruggiero Francavilla
Summary: The human gastrointestinal tract houses a complex and dynamic community of microorganisms, known as the gut microbiota, which interact with the host organism through molecular communication to maintain a symbiotic relationship. The balance and diversity of the gut microbiota are essential for the host's immune and metabolic homeostasis and protection against pathogens. Dysregulation of the microbiota composition, called dysbiosis, has been linked to the development of various diseases. Dietary manipulation of the gut microbiota using biomodulators such as prebiotics, probiotics, symbionts, and postbiotics has emerged as a promising strategy to restore and maintain a healthy microbiota. Recent advancements in the production of infant formulas have included the addition of prebiotics, probiotics, and postbiotics to create formulas that closely resemble the nutritional and biological composition of human milk.
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Sara Cicchinelli, Federico Valletta, Giulio De Luca, Yaroslava Longhitano, Marcello Candelli, Veronica Ojetti, Francesco Sardeo, Simone Navarra, Marcello Covino, Francesco Franceschi
Summary: This review reports the effects of probiotics administration in the most common autoimmune disease and inflammatory immune-mediated diseases. Studies suggest that probiotics may help restore gut eubiosis, thus affecting the pathogenesis and course of these diseases. Despite limited and sometimes contradictory research data, physicians should consider using probiotics as supportive measures in the treatment of patients with these diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Food Science & Technology
Jorge Armando Jimenez-Avalos, Gerardo Arrevillaga-Boni, Lorena Gonzalez-Lopez, Zaira Yunuen Garcia-Carvajal, Marisela Gonzalez-Avila
Summary: A healthy Human Gut Microbial Ecosystem (HGME) is essential for the proper functioning of the body, with dysbiosis potentially leading to various disorders. Different methods such as diet, probiotics, antibiotics, and Fecal Microbiota Transplantation (FMT) can help restore or maintain the balance of Gut Microbiota (GM) populations. New approaches such as engineered nanomaterials, phagotherapy, antimicrobial peptides, non-antibiotic drugs, vaccines, and immunoglobulins are promising strategies for modulating HGME.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Neurosciences
Hanif Ullah, Safia Arbab, Yali Tian, Chang-qing Liu, Yuwen Chen, Li Qijie, Muhammad Inayat Ullah Khan, Inam Ul Hassan, Ka Li
Summary: The gut microbiota has a significant impact on the host's physiology and pathology, communicating with different organs through hormone synthesis and regulation of body activity. Dysbiosis in the gut microbiota leads to gastrointestinal disorders that affect host physiology through abnormal microbial metabolites. This dysbiosis alters the bidirectional relationship between the central nervous system and gut microbiota, contributing to the pathogenesis of neurodevelopmental and neurological disorders. Increasing evidence suggests that gut microbes may play a role in the progression of neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and autism spectrum disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Yadong Zheng, Laura Bonfili, Tao Wei, Anna Maria Eleuteri
Summary: The gut-brain axis is a complex communication network between the gut and brain, involving neural, immune, and endocrine pathways. The gut microbiota plays an important role in this axis and its dysbiosis has been associated with neurodegenerative disorders. Manipulating the gut microbiota shows promise as a potential therapeutic target for these diseases.
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Agriculture, Dairy & Animal Science
Lilia M. Beltran-Barrientos, Hugo S. Garcia, Adrian Hernandez-Mendoza, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba
Summary: Hypertension is a risk factor for the development of cardiovascular diseases worldwide. While genetic and environmental factors play a role, recent research suggests that gut microbiota may also affect human health. Gut dysbiosis has been linked to metabolic diseases like hypertension, with studies showing that antihypertensive fermented milks might modulate gut microbiota.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Medicine, Research & Experimental
Basista Rabina Sharma, Swarna Jaiswal, P. Ravindra
Summary: This review provides an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the gut microbiota for the prevention and management of type 2 diabetes mellitus.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biology
Hanan E. Al-Rashidi
Summary: The human gut is colonized by a large number of microorganisms, primarily bacteria, which have a symbiotic relationship with the host. This microbial collection, known as the microbiota, interacts with gut epithelial and immune cells through vitamin synthesis or metabolic products. The gut microbiota plays a vital role in the growth and development of both adaptive and innate immune systems in humans, while the immune system helps regulate host-microbe symbiosis. However, disturbances in the composition of the gut microbiota, known as gut dysbiosis, can disrupt immune responses. This review focuses on the interaction between the gut microbiota and the immune system in both normal and dysbiotic states.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Sahar Behboud, Kavous Solhjoo, Saiedeh Erfanian, Majid Pirestani, Amir Abdoli
Summary: This study found that asymptomatic Blastocystis infection could alter the composition of gut bacteria in healthy individuals, including upregulation of certain bacteria and downregulation of others.
MICROBIAL PATHOGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Ziaur Rahman, Nagesh A. Bhale, Amol G. Dikundwar, Manoj P. Dandekar
Summary: Recent studies have highlighted the importance of gut microbiota in the neuropathology of post-stroke brain injury and recovery. Ingestion of prebiotics/probiotics has positive effects on brain injury, neuroinflammation, gut dysbiosis, and intestinal integrity. However, more research is needed to understand the disease-specific preference of different prebiotics/probiotics and their underlying mechanisms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Neurosciences
Gabriele Deidda, Manuele Biazzo
Summary: The physiological and pathological functions of the brain depend on both neuronal and non-neuronal populations. The gut brain, formed by microbial populations living in the gut, communicates with the human brain via the gut-brain axis and has an influence on brain functions, potentially becoming a therapeutic target for brain pathologies.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Microbiology
Muhammad Afzaal, Farhan Saeed, Yasir Abbas Shah, Muzzamal Hussain, Roshina Rabail, Claudia Terezia Socol, Abdo Hassoun, Mirian Pateiro, Jose M. Lorenzo, Alexandru Vasile Rusu, Rana Muhammad Aadil
Summary: The human gut contains a complex microbial community, which forms a connecting axis with other organs and plays a vital role in host-microbe interactions. Dysbiosis of the gut microbiota is linked to various human diseases. Understanding the role of gut microbiota in health and disease is crucial for maintaining health and treating diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell Biology
Amsha S. Alsegiani, Zahoor A. Shah
Summary: Recent research on intestinal microbiota has shown its significant contribution to the central nervous system during health and disease. Age-related changes in intestinal microbiota can lead to brain aging and neurodegenerative disorders, making maintaining a healthy gut microbiota crucial for a healthy body and aging.
NEURAL REGENERATION RESEARCH
(2022)
Review
Cell Biology
Amsha S. Alsegiani, Zahoor A. Shah
Summary: Recent research on intestinal microbiota and its impact on the central nervous system has gained significant attention. Changes in the gut microbiota due to aging can lead to brain aging and neurodegenerative diseases. Maintaining a healthy gut microbiota is crucial for overall health and aging, as dysbiosis can contribute to various chronic diseases. Understanding the mechanisms underlying gut microbiota changes will help identify biomarkers for aging-related conditions.
NEURAL REGENERATION RESEARCH
(2022)
Article
Environmental Sciences
Mojtaba Ehsanifar, Abolfazl Azami Tameh, Mahdi Farzadkia, Roshanak Rezaei Kalantari, Mahmood Salami Zavareh, Hossein Nikzaad, Ahmad Jonidi Jafari
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Geriatrics & Gerontology
M. Salami, A. Alinaghipour, R. Daneshvar, G. A. Hamidi, A. Agahi, M. Soheili, H. Akbari, S. M. Esmaeili Taba
AGING & MENTAL HEALTH
(2020)
Article
Cell Biology
Masoud Soheili, Mahmoud Salami
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Letter
Neurosciences
Masoud Soheili, Mahmoud Salami
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Developmental Biology
Fatemeh Aghighi Bidgoli, Mahmoud Salami, Sayyed Alireza Talaei
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2020)
Article
Physiology
F. S. Sajjadi, F. Aghighi, Z. Vahidinia, A. Azami-Tameh, M. Salami, S. A. Talaei
PHYSIOLOGY INTERNATIONAL
(2020)
Article
Pharmacology & Pharmacy
Azam Alinaghipour, Ghorbangol Ashabi, Esmail Riahi, Masoud Soheili, Mahmoud Salami, Fatemeh Nabavizadeh
Summary: The present study demonstrated the neuroprotective effects of nano-curcumin on behavioral and electrophysiological aspects of hippocampus-dependent memory in noise-exposed animals. Nano-curcumin treatment improved maze navigation and LTP induction, and reduced serum corticosterone levels.
PHARMACOLOGICAL REPORTS
(2022)
Article
Behavioral Sciences
Azam Alinaghipour, Mahmoud Salami, Fatemeh Nabavizadeh
Summary: Environmental noise stress leads to anxiety-like behavior and affects the gene expression of tight junctions and NMDA receptor subunits in the hippocampus of rats. Treatment with nanocurcumin can alleviate stress and anxiety, and restore the effects of noise exposure on tight junctions and NMDA receptor subunits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Medicine, Research & Experimental
Masoud Soheili, Azam Alinaghipour, Mahmoud Salami
Summary: An imbalance of oxidative agents can lead to oxidative stress, while beneficial gut bacteria play a crucial role in producing antioxidants. Modifying gut microbiota and probiotic supplements are suggested treatments to prevent or alleviate symptoms of neurological disorders associated with oxidative stress.
Article
Medicine, Research & Experimental
Masoud Soheili, Mohammad Karimian, Gholamali Hamidi, Mahmoud Salami
Summary: Alzheimer's disease is a common chronic neurodegenerative disease characterized by impaired learning and memory, with both synthetic and herbal medicines used for treatment. Herbal medicines can help alleviate symptoms and prevent disease progression.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Amir Hosein Hadidi Zavareh, Ramin Haji Khani, Bahareh Pakpour, Masoud Soheili, Mahmoud Salami
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Mahmoud Salami, Omid Reza Tamtaji, Mojgan Mohammadifar, Sayyed Alireza Talaei, Abolfazl Azami Tameh, Ali Reza Abed, Shahriar Shirkhoda, Ehsan Dadgostar, Mohsen Taghizadeh
GAZI MEDICAL JOURNAL
(2020)
Article
Medicine, Research & Experimental
Fatemeh Aghighi, Mojgan Mohammadifar, Hamidreza Banafsheh, Mahmoud Salami, Sayyed Alireza Talaei
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)
Article
Medicine, Research & Experimental
Mahsa Hadizadeh, Gholam Ali Hamidi, Mahmoud Salami
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)