Review
Nutrition & Dietetics
Yadong Zheng, Laura Bonfili, Tao Wei, Anna Maria Eleuteri
Summary: The gut-brain axis is a complex communication network between the gut and brain, involving neural, immune, and endocrine pathways. The gut microbiota plays an important role in this axis and its dysbiosis has been associated with neurodegenerative disorders. Manipulating the gut microbiota shows promise as a potential therapeutic target for these diseases.
Article
Clinical Neurology
Yasmina Ait Chait, Walid Mottawea, Thomas A. Tompkins, Riadh Hammami
Summary: Emerging evidence suggests that the microbiota-gut-brain axis plays an essential role in maintaining human homeostasis, with a particular focus on the bidirectional interplay between gut microbiota and the brain in psychiatric disorders. Attention has been drawn to the impact of psychotropic drugs on gut microbiota and the potential therapeutic strategies to alleviate dysbiosis associated with their intake.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Diren Beyoglu, Jeffrey R. Idle
Summary: Hepatocellular carcinoma (HCC) is a major complication of liver cirrhosis, causing over 2 million deaths globally each year. There are limited treatment options for liver cirrhosis and HCC, emphasizing the importance of early intervention. This article proposes dietary and therapeutic solutions that involve the gut microbiota and its consequences. Dysbiosis, the imbalance of gut microbiota, can be induced by various lifestyle factors and produce metabolites that may contribute to HCC development. The activation of toll-like receptor 4 (TLR4) by gram-negative bacteria in the liver can also contribute to HCC initiation and progression. To prevent HCC, maintaining a healthy gut microbiota through the use of probiotic supplements and prebiotic plant fibers is suggested. Additionally, the development of TLR4 antagonists and further nutrigenomic studies are deemed urgent to counteract dysbiosis and understand the effects of diet on the gut microbiota and liver.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Umair Shabbir, Muhammad Sajid Arshad, Aysha Sameen, Deog-Hwan Oh
Summary: The gut microbiota can influence brain immune homeostasis through the microbiota-gut-brain axis and play a key role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Modulating GM through diet, probiotics, or fecal microbiota transplantation may represent potential therapeutic strategies in treating AD.
Review
Nutrition & Dietetics
Sonia Croci, Lina Ilaras D'Apolito, Valeria Gasperi, Maria Valeria Catani, Isabella Savini
Summary: This passage discusses the relationship between metabolic syndrome and gut microbiota, indicating that dysbiosis may play a role in the pathogenesis of various chronic diseases; certain metabolites derived from microorganisms can trigger subclinical inflammatory processes related to MetS.
Review
Biochemistry & Molecular Biology
Sona Ciernikova, Aneta Sevcikova, Lubos Drgona, Michal Mego
Summary: Treatment resistance and adverse effects are important issues in cancer patient management. The use of microbiome in oncology is showing promising results. Favorable bacterial species and gut diversity are associated with increased treatment efficacy, while alterations in gut microbiome contribute to intestinal dysbiosis and treatment-induced toxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Nutrition & Dietetics
Vito Leonardo Miniello, Andrea Miniello, Laura Ficele, Aleksandra Skublewska-D'Elia, Vanessa Nadia Dargenio, Fernanda Cristofori, Ruggiero Francavilla
Summary: The human gastrointestinal tract houses a complex and dynamic community of microorganisms, known as the gut microbiota, which interact with the host organism through molecular communication to maintain a symbiotic relationship. The balance and diversity of the gut microbiota are essential for the host's immune and metabolic homeostasis and protection against pathogens. Dysregulation of the microbiota composition, called dysbiosis, has been linked to the development of various diseases. Dietary manipulation of the gut microbiota using biomodulators such as prebiotics, probiotics, symbionts, and postbiotics has emerged as a promising strategy to restore and maintain a healthy microbiota. Recent advancements in the production of infant formulas have included the addition of prebiotics, probiotics, and postbiotics to create formulas that closely resemble the nutritional and biological composition of human milk.
Article
Nutrition & Dietetics
Angelica Varesi, Elisa Pierella, Marcello Romeo, Gaia Bavestrello Piccini, Claudia Alfano, Geir Bjorklund, Abigail Oppong, Giovanni Ricevuti, Ciro Esposito, Salvatore Chirumbolo, Alessia Pascale
Summary: The dysregulation of gut microbiota is implicated in various diseases, including Alzheimer's Disease (AD). This article reviews the role of gut microbiota in brain health and disease and presents evidence for its dysregulation in AD patients. It discusses the potential of using dysbiosis as a diagnostic tool and explores the therapeutic interventions using prebiotics, probiotics, fecal microbiota transplantation, and diets in AD.
Review
Biochemistry & Molecular Biology
Davide Banfi, Elisabetta Moro, Annalisa Bosi, Michela Bistoletti, Silvia Cerantola, Francesca Crema, Fabrizio Maggi, Maria Cecilia Giron, Cristina Giaroni, Andreina Baj
Summary: This article discusses the role of the microbiota-gut-brain axis in the pathogenesis of Inflammatory Bowel Disease (IBD) and the impact of microbial-derived metabolites on the development of IBD-related symptoms. It points out that mood disorders and heightened stress responses may affect the severity of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ruxandra Florentina Ionescu, Robert Mihai Enache, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: This article summarizes the recent findings on the correlation between gestational diabetes mellitus (GDM) and dysbiosis, as well as the prevention and treatment methods. The most common changes in the microbiome of GDM patients are an increase in Firmicutes phylum or a decrease in Bacteroidetes and Actinobacteria phyla. Gut dysbiosis persists postpartum and affects the development of newborns. Probiotic supplementation and regular physical activity have strong evidence in controlling blood glucose levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Amsha S. Alsegiani, Zahoor A. Shah
Summary: Recent research on intestinal microbiota and its impact on the central nervous system has gained significant attention. Changes in the gut microbiota due to aging can lead to brain aging and neurodegenerative diseases. Maintaining a healthy gut microbiota is crucial for overall health and aging, as dysbiosis can contribute to various chronic diseases. Understanding the mechanisms underlying gut microbiota changes will help identify biomarkers for aging-related conditions.
NEURAL REGENERATION RESEARCH
(2022)
Review
Cell Biology
Amsha S. Alsegiani, Zahoor A. Shah
Summary: Recent research on intestinal microbiota has shown its significant contribution to the central nervous system during health and disease. Age-related changes in intestinal microbiota can lead to brain aging and neurodegenerative disorders, making maintaining a healthy gut microbiota crucial for a healthy body and aging.
NEURAL REGENERATION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Min'an Zhao, Jiayi Chu, Shiyao Feng, Chuanhao Guo, Baigong Xue, Kan He, Lisha Li
Summary: The gut microbiota plays a crucial role in maintaining host health by enhancing digestion, protecting the intestinal barrier, and interacting with the immune system. Dysbiosis of the gut microbiota, caused by various factors, is a major contributor to inflammatory diseases. The mechanisms underlying these diseases resulting from gut microbiota dysbiosis are not well categorized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Ankita Banerjee, Lilesh Kumar Pradhan, Pradyumna Kumar Sahoo, Kautilya Kumar Jena, Nishant Ranjan Chauhan, Santosh Chauhan, Saroj Kumar Das
Summary: Increasing prevalence of neurological disorders is linked to gut microbiota and the gut-brain axis, as dysbiosis may contribute to disease progression.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Microbiology
Katherine Dinan, Timothy G. Dinan
Summary: The gut microbiota is a virtual organ that produces essential molecules for the brain and other organs. It plays a symbiotic role with humans, as we provide them with food and they provide us with necessary molecules. Factors such as diet, exercise, stress, disease, and medications affect the structure of the gut microbiota. This review explores the involvement of the gut microbiota in high-prevalence disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and autism. While there is potential for developing novel therapies targeting the gut microbiota, further large-scale studies are needed to establish a definitive causal link between these disorders and gut microbes.
Meeting Abstract
Developmental Biology
Gabriele Deidda, Martina Parrini, Shovan Naskar, Ignacio Fernandez Bozarth, Andrea Contestabile, Laura Cancedda
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Gabriele Deidda, Martina Parrini, Shovan Naskar, Ignacio F. Bozarth, Andrea Contestabile, Laura Cancedda
Article
Neurosciences
Laura Baroncelli, Maria Cristina Cenni, Riccardo Melani, Gabriele Deidda, Silvia Landi, Roberta Narducci, Laura Cancedda, Lamberto Maffei, Nicoletta Berardi
Article
Neurosciences
Gabriele Deidda, Manuela Allegra, Chiara Cerri, Shovan Naskar, Guillaume Bony, Giulia Zunino, Yuri Bozzi, Matteo Caleo, Laura Cancedda
NATURE NEUROSCIENCE
(2015)
Review
Neurosciences
Gabriele Deidda, Ignacio F. Bozarth, Laura Cancedda
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Marco dal Maschio, Diego Ghezzi, Guillaume Bony, Alessandro Alabastri, Gabriele Deidda, Marco Brondi, Sebastian Sulis Sato, Remo Proietti Zaccaria, Enzo Di Fabrizio, Gian Michele Ratto, Laura Cancedda
NATURE COMMUNICATIONS
(2012)
Article
Multidisciplinary Sciences
Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabile
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Roberto Colangeli, Roberto Di Maio, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovanni
NEUROBIOLOGY OF DISEASE
(2019)
Article
Clinical Neurology
Maurizio Casarrubea, Massimo Pierucci, Stefania Aiello, Daniel Cassar, Gabriele Deidda, Giuseppe Crescimanno, Giuseppe Di Giovanni
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Cristiano Bombardi, Francis Delicata, Claudio Tagliavia, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Philippe De Deurwaerdere, Giuseppe Di Giovanni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Philippe De Deurwaerdere, Marta Ramos, Rahul Bharatiya, Emilie Puginier, Abdeslam Chagraoui, Julien Manem, Eleonora Cuboni, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovanni
Article
Clinical Neurology
Maurizio Casarrubea, Caitlin Davies, Massimo Pierucci, Roberto Colangeli, Gabriele Deidda, Andrea Santangelo, Stefania Aiello, Giuseppe Crescimanno, Giuseppe Di Giovanni
Summary: Chronic nicotine exposure may increase anxiety-like behavior, and the LHb may play a role in the anxiety effect of chronic nicotine exposure.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Medicine, General & Internal
Manuele Biazzo, Gabriele Deidda
Summary: The human gut microbiota plays a crucial role in various human pathologies. Restoring the balance and composition of the gut microbiota through pre/probiotic supplementation or fecal microbiota transplantation shows promising therapeutic potential for a wide range of conditions, including gastrointestinal disorders, liver diseases, cancer, and brain disorders. This review examines the preparation methods, clinical trial evidence, and the importance of donor selection in fecal microbiota transplantation, aiming to stimulate discussion and explore new therapeutic perspectives.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Manuele Biazzo, Manuela Allegra, Gabriele Deidda
Summary: This article outlines the importance of gut microbiota in neurological diseases, with a focus on the role of Clostridioides difficile in patients with neurological diseases, and highlights the potential value of microbiota-based therapeutic strategies targeting this pathogen.
FRONTIERS IN NEUROSCIENCE
(2022)