Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
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Title
Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
Authors
Keywords
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Journal
Translational Psychiatry
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-05
DOI
10.1038/s41398-021-01238-5
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Note: Only part of the references are listed.- Fragile X syndrome and associated disorders: Clinical aspects and pathology
- (2020) Maria Jimena Salcedo-Arellano et al. NEUROBIOLOGY OF DISEASE
- FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
- (2020) Sneha Shah et al. Cell Reports
- Molecular Mechanisms of Synaptic Dysregulation in Fragile X Syndrome and Autism Spectrum Disorders
- (2019) Michael Telias Frontiers in Molecular Neuroscience
- A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders
- (2019) Claudia Bagni et al. NEURON
- The activity of the STriatal‐Enriched protein tyrosine Phosphatase (STEP) in neuronal cells is modulated by adenosine A 2A receptor
- (2019) Cinzia Mallozzi et al. JOURNAL OF NEUROCHEMISTRY
- Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies
- (2018) Anwesha Banerjee et al. BRAIN RESEARCH
- Protein synthesis levels are increased in a subset of individuals with fragile X syndrome
- (2018) Sébastien Jacquemont et al. HUMAN MOLECULAR GENETICS
- The adenosine A 2A receptor agonist T1–11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease
- (2018) Antonella Ferrante et al. NEUROBIOLOGY OF DISEASE
- Istradefylline reduces memory deficits in aging mice with amyloid pathology
- (2018) Anna G. Orr et al. NEUROBIOLOGY OF DISEASE
- STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice
- (2018) Manavi Chatterjee et al. NEUROPHARMACOLOGY
- Mavoglurant in Fragile X Syndrome: Results of two open-label, extension trials in adults and adolescents
- (2018) Randi Hagerman et al. Scientific Reports
- Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
- (2017) Elizabeth M. Berry-Kravis et al. NATURE REVIEWS DRUG DISCOVERY
- Multifarious Functions of the Fragile X Mental Retardation Protein
- (2017) Jenna K. Davis et al. TRENDS IN GENETICS
- Fragile X syndrome
- (2017) Randi J. Hagerman et al. Nature Reviews Disease Primers
- A Long-Term Study of Istradefylline Safety and Efficacy in Patients With Parkinson Disease
- (2015) Tomoyoshi Kondo et al. CLINICAL NEUROPHARMACOLOGY
- Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
- (2015) K. M. Huber et al. JOURNAL OF NEUROSCIENCE
- Fragile X disappointments upset autism ambitions
- (2015) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Inactivation of adenosine A 2A receptors reverses working memory deficits at early stages of Huntington's disease models
- (2015) Wei Li et al. NEUROBIOLOGY OF DISEASE
- Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease
- (2015) Shiraz Tyebji et al. NEUROBIOLOGY OF DISEASE
- SnapShot: FMRP mRNA Targets and Diseases
- (2014) Emanuela Pasciuto et al. CELL
- SnapShot: FMRP Interacting Proteins
- (2014) Emanuela Pasciuto et al. CELL
- Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs
- (2014) Daman Kumari et al. HUMAN MUTATION
- Fragile X syndrome: From protein function to therapy
- (2013) Claudia Bagni et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- BDNF in fragile X syndrome
- (2013) Maija L. Castrén et al. NEUROPHARMACOLOGY
- Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP
- (2013) Valentina Chiodi et al. NEUROPSYCHOPHARMACOLOGY
- The challenges of clinical trials in fragile X syndrome
- (2013) Sébastien Jacquemont et al. PSYCHOPHARMACOLOGY
- Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I, two proteins involved in exo-endocytosis of synaptic vesicles
- (2012) Cinzia Mallozzi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Spatial Object Recognition Enables Endogenous LTD that Curtails LTP in the Mouse Hippocampus
- (2012) J. J. Goh et al. CEREBRAL CORTEX
- Reduction of BDNF expression inFmr1knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits
- (2012) M. Uutela et al. GENES BRAIN AND BEHAVIOR
- Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
- (2012) C. A. Hoeffer et al. GENES BRAIN AND BEHAVIOR
- Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
- (2012) Aubin Michalon et al. NEURON
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
- (2011) Jennifer C. Darnell et al. CELL
- The Psychiatric Presentation of Fragile X: Evolution of the Diagnosis and Treatment of the Psychiatric Comorbidities of Fragile X Syndrome
- (2011) Michael R. Tranfaglia DEVELOPMENTAL NEUROSCIENCE
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome
- (2010) Dilja D. Krueger et al. Annual Review of Medicine
- Dysregulation of mTOR Signaling in Fragile X Syndrome
- (2010) A. Sharma et al. JOURNAL OF NEUROSCIENCE
- Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
- (2010) E. K. Osterweil et al. JOURNAL OF NEUROSCIENCE
- BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse
- (2010) Verna Louhivuori et al. NEUROBIOLOGY OF DISEASE
- Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling
- (2010) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor Function In Vivo
- (2009) L. Carim-Todd et al. JOURNAL OF NEUROSCIENCE
- Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway
- (2009) P. M. Canas et al. JOURNAL OF NEUROSCIENCE
- A Critical Evaluation of Adenosine A2A Receptors as Potentially “Druggable” Targets in Huntingtons Disease
- (2008) Patrizia Popoli et al. CURRENT PHARMACEUTICAL DESIGN
- A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome
- (2008) Jason B. Dictenberg et al. DEVELOPMENTAL CELL
- Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation
- (2008) J. A. Ronesi et al. JOURNAL OF NEUROSCIENCE
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