Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants

Synthesis and Function of Complex Sphingolipid Glycosylation

(2020) Jenny C. Mortimer et al.   TRENDS IN PLANT SCIENCE

Introducing an Optimization- and explicit Runge-Kutta- based Approach to Perform Dynamic Flux Balance Analysis

(2020) Wheaton L. Schroeder et al.   Scientific Reports

The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

(2019) Deanna L. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

(2019) Jonathan Strutz et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

(2019) Benjamin A Clarke et al.   eLife

Plant sphingolipids: Their importance in cellular organization and adaption

(2016) Louise V. Michaelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

In silico metabolic network analysis of Arabidopsis leaves

(2016) Veronique Beckers et al.   BMC Systems Biology

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

(2016) Georgios Savoglidis et al.   METABOLIC ENGINEERING

Orosomucoid Proteins Interact with the Small Subunit of Serine Palmitoyltransferase and Contribute to Sphingolipid Homeostasis and Stress Responses in Arabidopsis

(2016) Jian Li et al.   PLANT CELL

A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

(2016) Ali Khodayari et al.   Nature Communications

Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis

(2015) K. D. Luttgeharm et al.   BIOCHEMICAL JOURNAL

Computational modeling of sphingolipid metabolism

(2015) Weronika Wronowska et al.   BMC Systems Biology

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

(2015) Deanna Siow et al.   JOURNAL OF LIPID RESEARCH

Glucosylceramides are critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis

(2015) Joseph Msanne et al.   PLANT JOURNAL

Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance

(2015) Kyle D. Luttgeharm et al.   PLANT PHYSIOLOGY

Revisiting Plant Plasma Membrane Lipids in Tobacco: A Focus on Sphingolipids

(2015) Jean-Luc Cacas et al.   PLANT PHYSIOLOGY

Expression of the ORMDLS, Modulators of Serine Palmitoyltransferase, Is Regulated by Sphingolipids in Mammalian Cells

(2014) Sita D. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Sphingolipid  -Glucuronosyltransferase That Is Essential for Pollen Function in Arabidopsis

(2014) E. A. Rennie et al.   PLANT CELL

A note on the kinetics of enzyme action: A decomposition that highlights thermodynamic effects

(2013) Elad Noor et al.   FEBS LETTERS

Arabidopsis 56-Amino Acid Serine Palmitoyltransferase-Interacting Proteins Stimulate Sphingolipid Synthesis, Are Essential, and Affect Mycotoxin Sensitivity

(2013) A. N. Kimberlin et al.   PLANT CELL

Consistent Estimation of Gibbs Energy Using Component Contributions

(2013) Elad Noor et al.   PLoS Computational Biology

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic modelling of plant metabolic pathways

(2012) Johann M. Rohwer   JOURNAL OF EXPERIMENTAL BOTANY

Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates

(2012) Stefanie König et al.   NEW PHYTOLOGIST

Ensemble Modeling of Cancer Metabolism

(2012) Tahmineh Khazaei et al.   Frontiers in Physiology

Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism

(2011) Shakti Gupta et al.   BMC Systems Biology

Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana

(2011) Philipp Ternes et al.   NEW PHYTOLOGIST

Sphingolipids Containing Very-Long-Chain Fatty Acids Define a Secretory Pathway for Specific Polar Plasma Membrane Protein Targeting inArabidopsis

(2011) Jonathan E. Markham et al.   PLANT CELL

Sphingolipid Δ8 unsaturation is important for glucosylceramide biosynthesis and low-temperature performance in Arabidopsis

(2011) Ming Chen et al.   PLANT JOURNAL

Zea mays iRS1563: A Comprehensive Genome-Scale Metabolic Reconstruction of Maize Metabolism

(2011) Rajib Saha et al.   PLoS One

Conformational Studies on the Δ8(E,Z)-Sphingolipid Desaturase fromHelianthus annuuswith Chiral Fluoropalmitic Acids As Mechanistic Probes

(2010) Andreas Habel et al.   JOURNAL OF ORGANIC CHEMISTRY

Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models

(2010) Nathan E Lewis et al.   Molecular Systems Biology

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

AraGEM, a Genome-Scale Reconstruction of the Primary Metabolic Network in Arabidopsis

(2010) C. G. de Oliveira Dal'Molin et al.   PLANT PHYSIOLOGY

Ensemble modeling and related mathematical modeling of metabolic networks

(2009) Matthew L. Rizk et al.   Journal of the Taiwan Institute of Chemical Engineers

Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli

(2009) Adam M. Feist et al.   METABOLIC ENGINEERING

Ensemble Modeling for Aromatic Production in Escherichia coli

(2009) Matthew L. Rizk et al.   PLoS One

Glucosylceramide Biosynthesis is Involved in Golgi Morphology and Protein Secretion in Plant Cells

(2009) Su Melser et al.   TRAFFIC

Ensemble Modeling of Metabolic Networks

(2008) Linh M. Tran et al.   BIOPHYSICAL JOURNAL

Sphingolipid Long-Chain Base Hydroxylation Is Important for Growth and Regulation of Sphingolipid Content and Composition in Arabidopsis

(2008) M. Chen et al.   PLANT CELL

Functional Characterization of a Higher Plant Sphingolipid  4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis

(2008) L. V. Michaelson et al.   PLANT PHYSIOLOGY