MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

A protein quality control pathway at the mitochondrial outer membrane

(2020) Meredith B Metzger et al.   eLife

Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases

(2020) Isshin Shiiba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

(2020) Lilian Phu et al.   MOLECULAR CELL

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

(2020) Alban Ordureau et al.   MOLECULAR CELL

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

(2020) Emma V Rusilowicz-Jones et al.   Life Science Alliance

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

(2018) Lukasz Kowalski et al.   BMC BIOLOGY

Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1 ) in bipolar disorder

(2017) Takaoki Kasahara et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system

(2017) Piotr Bragoszewski et al.   Open Biology

Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion

(2016) Jyoti Kumari et al.   JOURNAL OF CELL SCIENCE

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

(2016) Byung-Hoon Lee et al.   NATURE

Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control

(2015) Song-Hee Kim et al.   FEBS Journal

The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

(2015) Young-Suk Yoo et al.   Nature Communications

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

(2014) S. Peter et al.   EMBO Molecular Medicine

Dynamic survey of mitochondria by ubiquitin

(2014) M. Escobar-Henriques et al.   EMBO REPORTS

RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome

(2013) Shruti Gupta et al.   CARCINOGENESIS

Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and autosomal dominant progressive external ophthalmoplegia

(2013) Sara Roos et al.   HUMAN MOLECULAR GENETICS

MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2

(2013) Ayumu Sugiura et al.   MOLECULAR CELL

Clinical and Molecular Features of POLG-Related Mitochondrial Disease

(2013) J. D. Stumpf et al.   Cold Spring Harbor Perspectives in Biology

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

(2012) S. De et al.   JOURNAL OF CELL SCIENCE

Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death

(2012) R. Yonashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 1 is degraded at G2/M phase through ubiquitylation by MARCH5

(2012) Yong-Yea Park et al.   Cell Division

Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia†

(2011) Neli Atanassova et al.   HUMAN MOLECULAR GENETICS

Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

(2011) Eric B. Dammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action

(2011) He-Xin Shi et al.   PLoS Pathogens

Ubiquitin–Proteasome System and mitochondria — Reciprocity

(2010) Nurit Livnat-Levanon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Degradation of an intramitochondrial protein by the cytosolic proteasome

(2010) V. Azzu et al.   JOURNAL OF CELL SCIENCE

A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein

(2010) Ayumu Sugiura et al.   MITOCHONDRION

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Mitochondrial Ubiquitin Ligase MITOL Ubiquitinates Mutant SOD1 and Attenuates Mutant SOD1-induced Reactive Oxygen Species Generation

(2009) Ryo Yonashiro et al.   MOLECULAR BIOLOGY OF THE CELL

DNA polymerase gamma and mitochondrial disease: Understanding the consequence of POLG mutations

(2008) Sherine S.L. Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi

(2008) Susanne Radke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY