Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

(2020) Mushtaq Hussain et al.   JOURNAL OF MEDICAL VIROLOGY

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

(2020) Christian A. Devaux et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

(2020) Ye Qiu et al.   MICROBES AND INFECTION

Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19

(2020) Jiewen Fu et al.   MOLECULAR BIOLOGY REPORTS

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children

(2020) Elena Ciaglia et al.   Frontiers in Pediatrics

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

(2020) Amr H. Sawalha et al.   CLINICAL IMMUNOLOGY

Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human

(2020) Sabyasachi Senapati et al.   JOURNAL OF GENETICS

ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

(2020) Bruna G G Pinto et al.   JOURNAL OF INFECTIOUS DISEASES

Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection

(2020) Müşerref Duygu Saçar Demirci et al.   PeerJ

Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea

(2020) Ki Ho Hong et al.   Annals of Laboratory Medicine

Impact of Host Genetics and Biological Response Modifiers on Respiratory Tract Infections

(2019) Alicia Lacoma et al.   Frontiers in Immunology

Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou

(2018) Su-fen Zhang et al.   PLoS One

Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites

(2017) Y. Y. Chen et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction

(2017) Elham Ghadhanfar et al.   Reproductive Biology and Endocrinology

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Bat origin of human coronaviruses

(2015) Ben Hu et al.   Virology Journal

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Epigenetic Control of Immunity

(2014) M. Busslinger et al.   Cold Spring Harbor Perspectives in Biology

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Epigenomic control of the innate immune response

(2013) Joshua D Stender et al.   CURRENT OPINION IN PHARMACOLOGY

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element

(2013) Liesbeth Clinckemalie et al.   MOLECULAR ENDOCRINOLOGY

Association of ACE2 Genetic Variants With Blood Pressure, Left Ventricular Mass, and Cardiac Function in Caucasians With Type 2 Diabetes

(2011) S. K. Patel et al.   AMERICAN JOURNAL OF HYPERTENSION

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

(2009) Craig W. Day et al.   VIROLOGY

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer

(2008) Liesel M FitzGerald et al.   BMC CANCER

Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus with Cleaved S Protein as Revealed by Pseudotype Virus Bearing Cleaved S Protein

(2008) R. Watanabe et al.   JOURNAL OF VIROLOGY