Article
Biochemical Research Methods
Shuhui Meng, Tingting Wang, Qianqian Zhao, Qiu Hu, Yulan Chen, Heng Li, Cuilian Liu, Dongzhou Liu, Xiaoping Hong
Summary: Dermatomyositis and polymyositis are autoimmune diseases characterized by muscle weakness. Proteomics analysis revealed differential expression of plasma exosomal proteins related to the complement and coagulation cascade pathway in these diseases. These proteins correlated with clinical parameters and could serve as predictors for disease. Additional proteins were also identified and validated, suggesting their potential significance in the pathogenesis of the diseases.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Immunology
Huan Zhong, Chenyi Lou, Bingxin Ren, Yi Zhou
Summary: This study investigated the transcriptional changes in the stomachs of tilapia after IGF-1 injection. The results showed that IGF-1 injection altered gene expression related to amino acid transporting, complement and coagulation cascades.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lan Zhou, Jun-Hong Chai, Yi Zhang, Xiao-Jie Jing, Xiang-Wen Kong, Jun Liang, Yong-Gang Xia
Summary: This study found that amygdalin may be a promising agent for treating rheumatoid arthritis by regulating the complement and coagulation cascades.
Article
Medicine, Research & Experimental
Patrick Malcolm Siegel, Balint Andras Barta, Lukas Orlean, Ines Derya Steenbuck, Miguel Cosenza-Contreras, Tobias Wengenmayer, Georg Trummer, Dennis Wolf, Dirk Westermann, Oliver Schilling, Philipp Diehl
Summary: This study aimed to characterize the serum proteome of patients receiving VA-ECMO. The results showed significant differences in the serum proteome between VA-ECMO patients and controls, as well as changes from day 1 to day 3. Many proteins involved in inflammation and coagulation were found to be differentially expressed. Survivors and non-survivors could be differentiated based on their serum proteomes on day 3 according to PLS-DA analysis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Ikram Ayoub, Yves Dauvilliers, Lucie Barateau, Thais Vermeulen, Emmanuelle Mouton-Barbosa, Marlene Marcellin, Anne Gonzalez-de-Peredo, Catharina C. Gross, Abdelhadi Saoudi, Roland Liblau
Summary: This study conducted a comparative proteomics analysis of the cerebrospinal fluid (CSF) from 21 recent-onset narcolepsy type 1 (NT1) patients, and found that the complement and coagulation systems were significantly activated in NT1 patients. This suggests an ongoing inflammatory process in NT1 patients, at least partially contributed by complement dysregulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Lina Youssef, Francesca Crovetto, Rui Vasco Simoes, Jezid Miranda, Cristina Paules, Miquel Blasco, Marta Palomo, Hector Garcia-Caldero, Olga Tura-Ceide, Ana Paula Dantas, Virginia Hernandez-Gea, Pol Herrero, Nuria Canela, Josep Maria Campistol, Joan Carles Garcia-Pagan, Maribel Diaz-Ricart, Eduard Gratacos, Fatima Crispi
Summary: This study utilized metabolomic analysis to investigate the pathophysiological pathways involved in early-onset severe preeclampsia, revealing six altered metabolic pathways that may play a role in the development of this condition.
Article
Cell Biology
Yu Shangguan, Yinglan Wang, Wei Shi, Ruonan Guo, Zhipeng Zeng, Wenlong Hu, Wanxia Cai, Qiang Yan, Yong Xu, Donge Tang, Yong Dai
Summary: This study identified 373 differentially expressed proteins and found functional enrichment related to angiogenesis and the immune system. Potential biomarkers for PE diagnosis and new therapeutic targets were proposed. Additionally, acetylome analysis revealed 700 acetylation sites on 585 proteins, suggesting their involvement in the pathogenesis of PE.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Emmanuel Bujold, Alexandre Fillion, Florence Roux-Dalvai, Marie Pier Scott-Boyer, Yves Giguere, Jean-Claude Forest, Clarisse Gotti, Genevieve Laforest, Paul Guerby, Arnaud Droit
Summary: This study demonstrated that maternal urine proteomic profiling can differentiate women with and without preeclampsia. Specific proteins like ceruloplasmin and serpin A7 were upregulated in maternal urine before the diagnosis of preeclampsia and fetal growth restriction, suggesting their potential role as biomarkers for early detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Michelle Broekhuizen, Emilie Hitzerd, Thierry P. P. van den Bosch, Jasper Dumas, Robert M. Verdijk, Bas B. van Rijn, A. H. Jan Danser, Casper H. J. van Eijck, Irwin K. M. Reiss, Dana A. M. Mustafa
Summary: This study revealed distinct immunological alterations in early-onset preeclampsia compared to late-onset preeclampsia, with reduced expression of complement and Toll-like receptor associated genes, as well as decreased numbers of mast cells and M2 macrophages in early-onset preeclampsia placentas. Tailored treatments for each subtype may be desirable based on the differing immune profiles observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jie Ren, Konstantinos Tsilafakis, Liang Chen, Konstantinos Lekkos, Ioanna Kostavasili, Aimilia Varela, Dennis Cokkinos, Constantinos H. Davos, Xiaogang Sun, Jiangping Song, Manolis Mavroidis
Summary: The study found activation of the complement system in the myocardium of ARVC patients, with autoantibodies against myocardial proteins possibly contributing to this mechanism. Crosstalk between the complement and coagulation systems exacerbated myocardial injury in ARVC mice, which was reduced by using the thrombin inhibitor lepirudin. Patients showed significantly elevated plasma levels of sC5b9 and thrombin, which were correlated with all-cause mortality.
Article
Immunology
Xinyu Zhang, Zenghui Li, Wei Liu, Juanjuan Du, Yun Liu, Ningjun Yu, Chao Liu, Mei Zeng, Xiaoming Zhang
Summary: This study analyzed whole blood samples, serum samples, and pancreatic tissues of IEP and ANP patients and rat models to explore the differences in pathogenesis between the two conditions. The results indicate that the complement and coagulation cascades pathway plays a significant role in ANP, with proteins such as C3, CFI, α2-macroglobulin, C9, and Serpinc1 being potentially involved in promoting pancreatic necrosis and worsening the severity of ANP.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Plant Sciences
Hui-hui Sun, Xin-lou Chai, Hong-li Li, Jing-yun Tian, Kun-xiu Jiang, Xing-zhuo Song, Xi-rui Wang, Yong-sheng Fang, Qingxuan Ji, Hanying Liu, Gai-mei Hao, Wei Wang, Jing Han
Summary: Fufang Xueshuantong (FXST) is a traditional Chinese patent medicine used for treating diabetic retinopathy, showing positive effects on haemodynamics and morphological alterations of diabetic rat retinas. The pharmacological mechanism of FXST involves complement and coagulation cascades as well as the PPAR signalling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Mei-Mei Gao, Hang Shi, Hua-Juan Yan, Yue-Sheng Long
Summary: FMRP deficit is a common cause of FXS, which is characterized by intellectual disability and ASD. A proteomic analysis identified 100 differentially abundant proteins in the PFC of Fmr1 knockout mice, and bioinformatical analysis showed that these proteins were mainly enriched in the immune system, extracellular part, and complement and coagulation cascades.
JOURNAL OF PROTEOMICS
(2023)
Article
Engineering, Biomedical
Abba E. Coron, Davi M. Fonseca, Animesh Sharma, Geir Slupphaug, Berit L. Strand, Anne Mari A. Rokstad
Summary: This study investigated the protein adsorption profiles of alginate hydrogel microspheres and evaluated their biological significance using mass spectrometry-based proteomics. Different microspheres exhibited distinct inflammatory and fibrotic responses. Proteomic profiling revealed complement and coagulation as the top enriched pathways, indicating the potential role of these pathways in host response.
MATERIALS TODAY BIO
(2022)
Article
Cell Biology
Zheng Gong, Yuming He, Xiao Mi, Chengcheng Li, Xiaoran Sun, Guoqiang Wang, Leo Li, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai, Liang Wang, Zhongyuan Liu
Summary: The study identifies differential gene expression in the complement and coagulation cascades pathway as predictive biomarkers for the efficacy of immune checkpoint inhibitors in patients with metastatic urothelial cancer. A risk score based on these genes was constructed and found to be associated with patient response and overall survival.
Article
Obstetrics & Gynecology
Nuria Banos, Xavier P. Burgos-Artizzu, Brenda Valenzuela-Alcaraz, David Coronado-Gutierrez, Alvaro Perez-Moreno, Julia Ponce, Eduard Gratacos, Montse Palacio
Summary: This study evaluated the reproducibility of ultrasound cervical length (CL) measurement in the second trimester and found moderate agreement among intra- and inter-observers. However, wide disagreements were observed when using specific cutoffs to classify patients, highlighting the importance of training and quality assessments when considering the universal application of CL measurement for screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Iolanda Jordan, Mariona Fernandez de Sevilla, Victoria Fumado, Quique Bassat, Elisenda Bonet-Carne, Claudia Fortuny, Aleix Garcia-Miquel, Cristina Jou, Cristina Adroher, Maria Mele Casas, Monica Girona-Alarcon, Maria Hernandez Garcia, Gemma Pons Tomas, Sara Ajanovic, Sara Arias, Nuria Balanza, Barbara Baro, Pere Millat-Martinez, Rosauro Varo, Sergio Alonso, Enric Alvarez-Lacalle, Daniel Lopez, Joana Claverol, Marta Cubells, Pedro Brotons, Anna Codina, Daniel Cuadras, Patricia Bruijning-Verhagen, Saul Faust, Alasdair Munro, Carmen Munoz-Almagro, Marti Catala, Clara Prats, Juan Jose Garcia-Garcia, Eduard Gratacos
Summary: The transmission rate of SARS-CoV-2 infection among children and adult staff in summer schools in Barcelona was lower than the general population, indicating that schools under strict preventive measures are unlikely to be significant sources of transmission.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Acoustics
M. Perez-Cruz, O. Gomez, M. Gibert, N. Masoller, E. Marimon, D. Lip-Sosa, M. Bennasar, E. Bonet-Carne, M. D. Gomez-Roig, J. M. Martinez-Crespo, E. Gratacos, E. Eixarch
Summary: The study aimed to evaluate corpus callosum size in fetuses with isolated major congenital heart defects using neurosonography. Findings revealed that fetuses with major CHD had a smaller corpus callosum compared to controls, particularly in the subgroup with expected poorer brain oxygen supply. This suggests sonographic corpus callosum size could serve as a clinically feasible marker of abnormal white matter development in congenital heart defects.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Genetics & Heredity
Rebecca N. Spencer, Kurt Hecher, Gill Norman, Karel Marsal, Jan Deprest, Alan Flake, Francesc Figueras, Christoph Lees, Steve Thornton, Kathleen Beach, Marcy Powell, Fatima Crispi, Anke Diemert, Neil Marlow, Donald M. Peebles, Magnus Westgren, Helena Gardiner, Eduard Gratacos, Jana Brodszki, Albert Batista, Helen Turier, Mehali Patel, Beverley Power, James Power, Gillian Yaz, Anna L. David
Summary: This study aimed to improve safety monitoring for developing pregnancy drugs, devices, and interventions by creating AE terminology. An international multidisciplinary group filled gaps in definitions and severity grading through a modified Delphi process, allowing systematic consistent AE assessment in pregnancy trials.
PRENATAL DIAGNOSIS
(2022)
Article
Genetics & Heredity
Lennart Van der Veeken, Francesca M. Russo, Ewelina Litwinska, Olga Gomez, Doaa Emam, Liesbeth Lewi, David Basurto, Stephen Van der Veeken, Luc De Catte, Eduard Gratacos, Elisenda Eixarch, Kypros Nicolaides, Jan Deprest
Summary: Fetuses with isolated left-sided CDH exhibit a small cerebellum and reduced MCA peak systolic velocity. Disease severity is correlated to changes in TCD and MCA Doppler values. Follow-up studies are needed to determine the impact of these changes on neurodevelopment.
PRENATAL DIAGNOSIS
(2022)
Article
Obstetrics & Gynecology
Ben Van Calster, Alexandra Benachi, Kypros H. Nicolaides, Eduard Gratacos, Christoph Berg, Nicola Persico, Glenn J. Gardener, Michael Belfort, Yves Ville, Greg Ryan, Anthony Johnson, Haruhiko Sago, Przemyslaw Kosinski, Pietro Bagolan, Tim Van Mieghem, Philip L. J. DeKoninck, Francesca M. Russo, Stuart B. Hooper, Jan A. Deprest
Summary: This analysis suggests that fetoscopic endoluminal tracheal occlusion improves survival in cases of moderate and severe lung hypoplasia. The timing of balloon insertion may impact the treatment effect, but further research is needed to determine its precise influence due to the limited sample size and confounding factors. In particular, early insertion of the balloon greatly increases the risk of preterm delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Sergio Alonso, Marti Catala, Daniel Lopez, Enric Alvarez-Lacalle, Iolanda Jordan, Juan Jose Garcia-Garcia, Victoria Fumado, Carmen Munoz-Almagro, Eduard Gratacos, Nuria Balanza, Rosauro Varo, Pere Millat, Barbara Baro, Sara Ajanovic, Sara Arias, Joana Claverol, Mariona Fernandez de Sevilla, Elisenda Bonet-Carne, Aleix Garcia-Miquel, Ermengol Coma, Manuel Medina-Peralta, Francesc Fina, Clara Prats, Quique Bassat
Summary: The reopening of schools in Catalonia appeared to be safe and the preventive measures in place were effective in detecting and containing transmission. The risk of transmission within schools was found to be relatively low.
Article
Biology
Lina Youssef, Francesca Crovetto, Rui Vasco Simoes, Jezid Miranda, Cristina Paules, Miquel Blasco, Marta Palomo, Hector Garcia-Caldero, Olga Tura-Ceide, Ana Paula Dantas, Virginia Hernandez-Gea, Pol Herrero, Nuria Canela, Josep Maria Campistol, Joan Carles Garcia-Pagan, Maribel Diaz-Ricart, Eduard Gratacos, Fatima Crispi
Summary: This study utilized metabolomic analysis to investigate the pathophysiological pathways involved in early-onset severe preeclampsia, revealing six altered metabolic pathways that may play a role in the development of this condition.
Meeting Abstract
Hematology
Ana Belen Moreno-Castano, Sara Fernandez, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Patricia Molina, Marc Pino, Valentin Ortiz-Maldonado, Julio Delgado, Carlos Fernandez De Larrea, Alvaro Urbano-Ispizua, Gines Escolar, Enric Carreras, Francesc Fernandez-Aviles, Pedro Castro, Maribel Diaz-Ricart
Meeting Abstract
Hematology
Silvia Escribano Serrat, Paola Charry, Luis Gerardo Rodriguez-Lobato, Ana Belen Moreno-Castano, Maria Suarez-Lledo, Nuria Martinez-Cibrian, Maria Teresa Solano, Jordi Arcarons, Meritxell Nomdedeu, Joan Cid, Miquel Lozano, Alexandra Pedraza, Laura Rosinol, Jordi Esteve, Alvaro Urbano-Ispizua, Marta Palomo, Francesc Fernandez-Aviles, Maria Carmen Martinez Munoz, Maribel Diaz-Ricart, Enric Carreras, Montserrat Rovira, Maria Queralt Salas
Article
Biophysics
Julia Martinez-Sanchez, Roger Pascual-Diaz, Marta Palomo, Ana Belen Moreno-Castano, Helena Ventosa, Maria Queralt Salas, Montserrat Rovira, Gines Escolar, Enric Carreras, Maribel Diaz-Ricart
Summary: Post-transplantation cyclophosphamide (PTCy) reduces the occurrence of graft-versus-host disease (GVHD). Endothelial damage in allogeneic hematopoietic cell transplantation (allo-HCT) is caused by various factors and plays a role in HCT-related complications like GVHD. The impact of PTCy on the endothelium is not well understood. In this study, the researchers compared the effects of the cyclophosphamide analog MAF and cyclosporine A (CSA) on endothelial cells (ECs), and found that both compounds caused endothelial damage, but with different characteristics and intensities.
BONE MARROW TRANSPLANTATION
(2023)
Article
Cell Biology
Julia Martinez-Sanchez, Marta Palomo, Alexandra Pedraza, Ana Belen Moreno-Castano, Sergi Torramade-Moix, Montserrat Rovira, Maria Queralt Salas, Joan Cid, Gines Escolar, Olaf Penack, Enric Carreras, Maribel Diaz-Ricart
Summary: This study compared the endothelial proteomic profiles in response to serum from steroid-refractory acute GVHD (SR-aGVHD) and steroid-sensitive acute GVHD (SS-aGVHD) patients. The differentially expressed proteins were mainly associated with oxidative phosphorylation, inflammation and angiogenesis, cell survival, and oxidative stress. These findings provide insights into the mechanisms of response to steroids and may serve as potential biomarkers for steroid-treatment response in SR-aGVHD patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Ana Belen Moreno-Castano, Sara Fernandez, Helena Ventosa, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Valentin Ortiz-Maldonado, Julio Delgado, Carlos Fernandez de Larrea, Alvaro Urbano-Ispizua, Olaf Penack, J. M. Nicolas, Adrian Tellez, Gines Escolar, Enric Carreras, Francesc Fernandez-Aviles, Pedro Castro, Maribel Diaz-Ricart
Summary: CAR-T cell-based immunotherapy for hematological malignancies may lead to cytokine release and immune effector cell-associated neurotoxicity syndromes. This study found that markers of endothelial dysfunction, innate immunity activation, and hemostatic imbalance could potentially be used as laboratory tools for predicting and differentiating toxicities, as well as determining their severity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Genis Camprecios, Marina Vilaseca, Dinesh M. Tripathi, Carla Montironi, Alba Diaz, Daniel Aguilar, Hector Garcia-Caldero, Rosa Montanes, Aina Anton, Virginia Hernandez-Gea, Joan Carles Garcia-Pagan
Summary: PSVD is a rare vascular liver disease with unknown etiology that may lead to portal hypertension. Researchers have developed three rat models for PSVD and found that the Selfox model faithfully reproduces the main alterations observed in PSVD, providing a significant preclinical model for drug testing and the development of new therapeutic targets for this rare condition.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Genis Camprecios, Aina Anton, Anna Oncins, Carla Montironi, Maria Ruart, Rosa Montanes, Hector Garcia-Caldero, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Liver sinusoidal endothelial cells (LSEC) are key elements in regulating the liver response to injury and regeneration. Endothelial autophagy plays a crucial role in protecting cells from injury-induced oxidative stress and fibrosis. However, this study found that endothelial autophagy is not essential for liver regeneration after partial hepatectomy (PHx).
LIVER INTERNATIONAL
(2023)