A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

(2020) Francesca Conradie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

(2020) Joseph M. Cicchese et al.   Frontiers in Pharmacology

The Role of Fluoroquinolones in the Treatment of Tuberculosis in 2019

(2019) A. D. Pranger et al.   DRUGS

Chemogenomic model identifies synergistic drug combinations robust to the pathogen microenvironment

(2019) Murat Cokol et al.   PLoS Computational Biology

Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization

(2019) Natasha Strydom et al.   PLOS MEDICINE

Modelling the effects of bacterial cell state and spatial location on tuberculosis treatment: Insights from a hybrid multiscale cellular automaton model

(2018) Ruth Bowness et al.   JOURNAL OF THEORETICAL BIOLOGY

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

(2018) Elsje Pienaar et al.   PLoS One

Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis

(2018) Chen Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update

(2017) Dennis Falzon et al.   EUROPEAN RESPIRATORY JOURNAL

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

(2017) Elsje Pienaar et al.   PLoS Computational Biology

Experimental study of tuberculosis: From animal models to complex cell systems and organoids

(2017) Kaori L. Fonseca et al.   PLoS Pathogens

Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis

(2017) Murat Cokol et al.   Science Advances

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection

(2017) Michael Zimmermann et al.   mSystems

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

(2016) Soumya Swaminathan et al.   CLINICAL INFECTIOUS DISEASES

Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions

(2016) Elsje Pienaar et al.   INFECTION AND IMMUNITY

Tuberculosis

(2016) Keertan Dheda et al.   LANCET

Chemogenomics and orthology‐based design of antibiotic combination therapies

(2016) Sriram Chandrasekaran et al.   Molecular Systems Biology

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

(2016) Aleidy Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of Drug Penetration in Tuberculosis Lesions

(2016) Jansy P. Sarathy et al.   ACS Infectious Diseases

In silico evaluation and exploration of antibiotic tuberculosis treatment regimens

(2015) Elsje Pienaar et al.   BMC Systems Biology

A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment

(2015) Elsje Pienaar et al.   JOURNAL OF THEORETICAL BIOLOGY

The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tuberculosis Drug Discovery and Development Pipeline and Emerging Drug Targets

(2015) K. Mdluli et al.   Cold Spring Harbor Perspectives in Medicine

Tuberculosis treatment and management—an update on treatment regimens, trials, new drugs, and adjunct therapies

(2015) Alimuddin Zumla et al.   Lancet Respiratory Medicine

Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

(2014) Emmanuel Chigutsa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation duringMycobacterium tuberculosisInfection

(2014) Nicholas A. Cilfone et al.   JOURNAL OF IMMUNOLOGY

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

(2014) Véronique Dartois   NATURE REVIEWS MICROBIOLOGY

Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis

(2014) Stephen H. Gillespie et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis

(2014) Amina Jindani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes

(2013) J. G. Pasipanodya et al.   JOURNAL OF INFECTIOUS DISEASES

Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

(2013) Nicholas A. Cilfone et al.   PLoS One

Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy

(2012) Jotam G. Pasipanodya et al.   CLINICAL INFECTIOUS DISEASES

Population Pharmacokinetics of Ethambutol in South African Tuberculosis Patients

(2011) Siv Jönsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiscale Computational Modeling Reveals a Critical Role for TNF-  Receptor 1 Dynamics in Tuberculosis Granuloma Formation

(2011) M. Fallahi-Sichani et al.   JOURNAL OF IMMUNOLOGY

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection

(2009) J. C. J. Ray et al.   JOURNAL OF IMMUNOLOGY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA