Is amyloid-β harmful to the brain? Insights from human imaging studies

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

(2015) Osama Sabri et al.   Alzheimers & Dementia

Clinicopathologic and11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

(2015) Melissa E. Murray et al.   BRAIN

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

(2015) Sylvia Villeneuve et al.   BRAIN

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Brain structure and function as mediators of the effects of amyloid on memory

(2015) N. Mattsson et al.   NEUROLOGY

TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?

(2015) Rudolph E. Tanzi   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

(2015) Craig Curtis et al.   JAMA Neurology

Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease

(2014) Niklas Mattsson et al.   BRAIN

Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects

(2014) Hyun Kook Lim et al.   BRAIN

Local Activity Determines Functional Connectivity in the Resting Human Brain: A Simultaneous FDG-PET/fMRI Study

(2014) V. Riedl et al.   JOURNAL OF NEUROSCIENCE

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Neural compensation in older people with brain amyloid-β deposition

(2014) Jeremy A Elman et al.   NATURE NEUROSCIENCE

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging

(2014) M. R. Brier et al.   NEUROLOGY

Association of hypometabolism and amyloid levels in aging, normal subjects

(2014) V. J. Lowe et al.   NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

(2014) Elizabeth C. Mormino et al.   JAMA Neurology

Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

(2014) Jon B Toledo et al.   Acta Neuropathologica Communications

The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly

(2013) Miranka Wirth et al.   Alzheimers & Dementia

Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β-amyloid

(2013) Susan M. Landau et al.   ANNALS OF NEUROLOGY

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease

(2013) Yen Ying Lim et al.   BRAIN

Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not  -Amyloid in Cognitively Normal Older Individuals

(2013) M. Wirth et al.   JOURNAL OF NEUROSCIENCE

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Amyloid burden and neural function in people at risk for Alzheimer's Disease

(2013) Sterling C. Johnson et al.   NEUROBIOLOGY OF AGING

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

(2013) T. Hedden et al.   NEUROLOGY

Preclinical AD predicts decline in memory and executive functions in subjective complaints

(2013) A. C. van Harten et al.   NEUROLOGY

Atrophy Rates in Asymptomatic Amyloidosis: Implications for Alzheimer Prevention Trials

(2013) K. Abigail Andrews et al.   PLoS One

Energetic cost of brain functional connectivity

(2013) D. Tomasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-sectional and Longitudinal Analysis of the Relationship Between Aβ Deposition, Cortical Thickness, and Memory in Cognitively Unimpaired Individuals and in Alzheimer Disease

(2013) Vincent Doré et al.   JAMA Neurology

Selective Worsening of Brain Injury Biomarker Abnormalities in Cognitively Normal Elderly Persons With β-Amyloidosis

(2013) David S. Knopman et al.   JAMA Neurology

Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?

(2013) Jennifer L. Whitwell et al.   NeuroImage-Clinical

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

(2012) Susan M. Landau et al.   ANNALS OF NEUROLOGY

Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly

(2012) Hwamee Oh et al.   HUMAN BRAIN MAPPING

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Loss of Intranetwork and Internetwork Resting State Functional Connections with Alzheimer's Disease Progression

(2012) M. R. Brier et al.   JOURNAL OF NEUROSCIENCE

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

(2012) Adam S Fleisher et al.   LANCET NEUROLOGY

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

Longitudinal imaging pattern analysis (SPARE-CD index) detects early structural and functional changes before cognitive decline in healthy older adults

(2012) Vanessa H. Clark et al.   NEUROBIOLOGY OF AGING

Accelerated cortical atrophy in cognitively normal elderly with high  -amyloid deposition

(2012) G. Chetelat et al.   NEUROLOGY

Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

(2012) D. S. Knopman et al.   NEUROLOGY

 -Amyloid burden in healthy aging: Regional distribution and cognitive consequences

(2012) K. M. Rodrigue et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Amyloid-β associated volume loss occurs only in the presence of phospho-tau

(2011) Rahul S. Desikan et al.   ANNALS OF NEUROLOGY

An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

(2011) Clifford R. Jack et al.   ANNALS OF NEUROLOGY

Effect of APOE ε4 Status on Intrinsic Network Connectivity in Cognitively Normal Elderly Subjects

(2011) Mary M. Machulda   ARCHIVES OF NEUROLOGY

Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer’s disease

(2011) Gaël Chételat et al.   BRAIN

CSF Biomarker and PIB-PET-Derived Beta-Amyloid Signature Predicts Metabolic, Gray Matter, and Cognitive Changes in Nondemented Subjects

(2011) M. Ewers et al.   CEREBRAL CORTEX

Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging

(2011) Elizabeth C. Mormino et al.   CEREBRAL CORTEX

Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution

(2011) M. H. Rosenbloom et al.   NEUROLOGY

Face-name associative memory performance is related to amyloid burden in normal elderly

(2011) Dorene M. Rentz et al.   NEUROPSYCHOLOGIA

Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42

(2010) Jonathan M. Schott et al.   ANNALS OF NEUROLOGY

Amyloid-β associated cortical thinning in clinically normal elderly

(2010) J. Alex Becker et al.   ANNALS OF NEUROLOGY

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42

(2010) Y. I. Sheline et al.   JOURNAL OF NEUROSCIENCE

Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals

(2010) Ira Driscoll et al.   NEUROBIOLOGY OF AGING

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

(2010) S. M. Resnick et al.   NEUROLOGY

 -Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

(2010) P. Bourgeat et al.   NEUROLOGY

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Cognitive Decline and Brain Volume Loss as Signatures of Cerebral Amyloid-β Peptide Deposition Identified With Pittsburgh Compound B

(2009) Martha Storandt et al.   ARCHIVES OF NEUROLOGY

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

(2009) T. Hedden et al.   JOURNAL OF NEUROSCIENCE

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia

(2008) Gil D. Rabinovici et al.   ANNALS OF NEUROLOGY

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX