Article
Multidisciplinary Sciences
Weike Schwarz, Stina Wegener, Gerhard Schertzinger, Helena Pannekens, Peter Schweyen, Georg Dierkes, Kristina Klein, Thomas A. Ternes, Joerg Oehlmann, Elke Dopp
Summary: The widespread use of plastics leads to plastic residues being found everywhere in the environment. The degradation processes of plastics under UV irradiation can cause leaching of potentially harmful compounds into the environment. This study investigated the toxicological effects of leachates from different types of plastic materials using in-vitro bioassays, and found genotoxic and estrogenic effects above safety levels in some samples. Further investigations are needed to understand the complex mixture of substances released by plastic materials and their potential harm.
Article
Microbiology
Lauren Wind, Ishi Keenum, Suraj Gupta, Partha Ray, Katharine Knowlton, Monica Ponder, W. Cully Hession, Amy Pruden, Leigh-Anne Krometis
Summary: This study tracks antibiotic resistance and associated microbiomes in an agroecosystem to identify key control points for the propagation of antibiotic resistance genes in vegetable production systems. Additional interventions may be needed to minimize the risk of propagating antibiotic resistance in the food chain.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Oncology
Nadia Harbeck, Andreas Schneeweiss, Peter Thuss-Patience, Kurt Miller, Claus Garbe, Frank Griesinger, Wilfried E. E. Eberhardt, Jens P. Klussmann, Barbara Wollenberg, Marc-Oliver Grimm, Thomas Zander, Diana Lueftner
Summary: HTA plays an essential role in evaluating the clinical and economic value of new interventions for cancer patients. While overall survival is a preferred criterion, incorporating end-points like pathological complete response and disease-free survival is crucial for patients with early cancer, as they provide important psychological benefits.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Manuela Piccardo, Francesca Provenza, Serena Anselmi, Monia Renzi
Summary: The most ignored category of microplastics pollution is glitter. Glitter leachate of nine types were tested for toxicity on model organisms in freshwater and saltwater. The results showed that photosynthesizing primary producers were the most sensitive, with higher sensitivity in marine environments.
Article
Thermodynamics
Laura Nebot-Andres, Daniel Calleja-Anta, Carlos Fossi, Ramon Cabello, Rodrigo Llopis
Summary: This study experimentally analyzed three different configurations of subcooling systems and found that they have practically the same energy efficiency, but with certain variations in cooling capacity and the greatest differences found in the subcooler.
INTERNATIONAL JOURNAL OF REFRIGERATION
(2022)
Article
Optics
Javier Portilla, Sergio Barbero
Summary: There is a trend in optical system design to consider real-world industrial demands and optimize the metrics for cost-performance trade-off. The end-to-end design, with the design metric as the expected quality index of the final image, is also gaining popularity. This article proposes an integrated approach to analyze the cost-performance trade-off in end-to-end designs, demonstrating its effectiveness with a simple optical model. The results show significant differences and performance improvements, particularly for lower-cost configurations.
Article
Engineering, Environmental
Serena Fabbri, Michael Z. Hauschild, Timothy M. Lenton, Mikolaj Owsianiak
Summary: The research suggests that climate tipping points have significant impacts on the earth system and human societies. However, current climate change assessment methods typically do not consider these impacts. The study proposes a new method for calculating climate tipping characterization factors for greenhouse gases, addressing uncertainties and covering multiple tipping points.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Shanshan Lv, Sen Li, Yichen Zhao, Guodong Wang
Summary: Robust parameter design and tolerance design are effective approaches for continuous product quality improvement. However, the traditional two-stage design approach is time-consuming and may lead to suboptimal parameter and tolerance levels. This paper proposes an integrated design model and uses a grey relational analysis technique to obtain optimal parameter and tolerance levels. A case study confirms the effectiveness of the proposed method, showing more reliable controllable factor levels and better tradeoffs among quality loss, tolerance cost, and predicted loss.
COMPUTERS & INDUSTRIAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Rachel-Ann A. Garibsingh, Elias Ndaru, Alisa A. Garaeva, Yueyue Shi, Laura Zielewicz, Paul Zakrepine, Massimiliano Bonomi, Dirk J. Slotboom, Cristina Paulino, Christof Grewer, Avner Schlessinger
Summary: ASCT2 is up-regulated in cancer and plays a crucial role in promoting cell proliferation by modulating intracellular glutamine levels; Inhibiting nutrient uptake via ASCT2 could be a potential strategy for cancer therapy; We designed a series of unique ASCT2 inhibitors using computational modeling and cryo-EM, providing a framework for the development of cancer therapeutics targeting ASCT2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Mario Petrollese, Giulia Concas, Francesco Lonis, Daniele Cocco
Summary: This paper conducts a techno-economic analysis of a hydrogen valley. The results demonstrate that a balanced supply from wind and solar energy can lead to improved efficiency and reduced hydrogen production costs.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Nowak, Maike Theis, Barbara D. Wichtmann, Anton Faron, Matthias F. Froelich, Fabian Tollens, Helena L. Geissler, Wolfgang Block, Julian A. Luetkens, Ulrike Attenberger, Alois M. Sprinkart
Summary: This study developed an end-to-end automated deep learning pipeline for the large-scale opportunistic assessment of body composition metrics and sarcopenia biomarkers in clinical routine, achieving high agreement between manual and fully automated analyses.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Chen, Xinyan Zhao, Hui Xu, Hao Ren, Tianhui Liu, Yu Wang, Dawei Yang, Zhenghan Yang
Summary: This study evaluated the potential of multiple MRI parameters for assessing APAP-induced hepatotoxicity in an experimental rat model. The results showed that MRI parameters such as precontrast T1 and Delta T1-T2/3 had promising potential in assessing the severity of early-stage hepatotoxicity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Limnology
Charlotte Carrier-Belleau, Ludovic Pascal, Christian Nozais, Philippe Archambault
Summary: This review examines the historical and current perspective of tipping point studies in terrestrial, freshwater, and marine ecological systems, highlighting the need to consider multiple drivers in different ecosystems. Experimental studies have focused on identifying tipping points at various levels of biological complexity, but there is still a lack of specific objectives in pinpointing these critical thresholds and considering the impact of multiple stressors on ecosystem dynamics.
LIMNOLOGY AND OCEANOGRAPHY
(2022)
Article
Thermodynamics
Artem Vodeniktov, Natalia Chichirova, Valeriia Melnikova
Summary: The article presents thermal test results of the condenser of the steam turbine PT-25-90 UTZ during off-design operation, showing a 75% decrease in the heat transfer coefficient compared to the design mode, with a maximum exhaust steam temperature of 154 degrees Celsius.
CASE STUDIES IN THERMAL ENGINEERING
(2021)
Article
Agronomy
Agnieszka Klimkowicz-Pawlas, Bozena Smreczak, Barbara Maliszewska-Kordybach
Summary: Agricultural land near urbanized/industrialized areas is exposed to continuous human activity and pollution deposition, leading to the need for ecological risk assessment. This study used an interdisciplinary approach, integrating data from chemical, ecotoxicological, and ecological analysis to assess the risk in a given area. The results showed that while the chemical risk index was high, the ecotoxicological and ecological indicators indicated no or low risk in most of the area.
Correction
Multidisciplinary Sciences
Daniele Mandrioli, Cristin E. Kearns, Lisa A. Bero
Article
Cell Biology
Eva Tibaldi, Federica Gnudi, Simona Panzacchi, Daniele Mandrioli, Andrea Vornoli, Marco Manservigi, Daria Sgargi, Laura Falcioni, Luciano Bua, Fiorella Belpoggi
Review
Environmental Sciences
Daria Sgargi, Balazs Adam, Lygia T. Budnik, Giovanni Dinelli, Horatiu Remus Moldovan, Melissa J. Perry, Paul T. J. Scheepers, Vivi Schluenssen, Joao Paulo Teixeira, Daniele Mandrioli, Fiorella Belpoggi
ENVIRONMENTAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Jianzhong Hu, Corina Lesseur, Yu Miao, Fabiana Manservisi, Simona Panzacchi, Daniele Mandrioli, Fiorella Belpoggi, Jia Chen, Lauren Petrick
Summary: The study found that exposure to glyphosate-based herbicides can significantly alter the urine metabolite profiles of rat dams and pups, with differences observed between female and male pups. There was a significant increase in homocysteine in both Roundup and glyphosate exposed pups, but only in males. Additionally, correlation analysis indicated a negative relationship between the gut microbiome Prevotella and homocysteine levels.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Robin Mesnage, Maxime Teixeira, Daniele Mandrioli, Laura Falcioni, Mariam Ibragim, Quinten Raymond Ducarmon, Romy Danielle Zwittink, Caroline Amiel, Jean-Michel Panoff, Emma Bourne, Emanuel Savage, Charles A. Mein, Fiorella Belpoggi, Michael N. Antoniou
Summary: The study revealed that standard regulatory toxicity tests may not accurately detect the health effects of pesticides, but in-depth multi-omics analysis can reveal metabolic perturbations. Low concentrations of pesticides were found to potentially trigger oxidative stress responses, affect gene expression in the liver, and lead to changes in DNA methylation.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Environmental Sciences
Colin L. Soskolne, Shira Kramer, Juan Pablo Ramos-Bonilla, Daniele Mandrioli, Jennifer Sass, Michael Gochfeld, Carl F. Cranor, Shailesh Advani, Lisa A. Bero
Summary: Epidemiology plays a crucial role in understanding health and disease, but its methods and language can be manipulated and misused. A toolkit has been created to help professionals detect bias and flaws in scientific studies related to public health. It is important to address financial conflicts of interest and improper study design to ensure transparency and validity in epidemiological research.
ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Corina Lesseur, Patrick Pirrotte, Khyatiben V. Pathak, Fabiana Manservisi, Daniele Mandrioli, Fiorella Belpoggi, Simona Panzacchi, Qian Li, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Shanna H. Swan, Jia Chen
Summary: High maternal urinary levels of Glyphosate were associated with longer anoclitoral distance (AGD-AC) in female infants, while increased levels of AMPA were associated with longer anofourchette distance (AGD-AF). No significant associations were found in male infants.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Julia M. L. Menon, Judith A. K. R. van Luijk, Janne Swinkels, Eva Lukas, Merel Ritskes-Hoitinga, Nel Roeleveld, Vivi Schlunssen, Daniele Mandrioli, Sebastian Hoffmann, Madalina Popa, Paul T. J. Scheepers
Summary: This review assessed available animal evidence on reproductive and developmental outcomes related to N2O inhalation to inform a health-based recommended occupational exposure limit. The study derived an OEL recommendation of 20 mg/m(3) based on the evidence gathered from animal studies.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Corina Lesseur, Khyatiben Pathak, Patrick Pirrotte, Melissa N. Martinez, Kelly K. Ferguson, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Daniele Mandrioli, Shanna H. Swan, Jia Chen
Summary: This study examined the association between prenatal glyphosate exposure and length of gestation, finding that maternal glyphosate and AMPA exposure were associated with shortened gestational length only among spontaneous deliveries. The results suggest widespread exposure to glyphosate in the general population, potentially impacting reproductive health. Larger confirmatory studies are needed to further investigate the effects, especially in vulnerable populations like pregnant women and newborns.
ENVIRONMENTAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Eric T. Knapke, Danielly de P. Magalhaes, Mohamed Aqiel Dalvie, Daniele Mandrioli, Melissa J. Perry
Summary: The global decline in sperm counts has been associated with the increasing exposure to endocrine-disrupting chemicals, particularly pesticides. A systematic review of 19 studies found consistent associations between pesticide exposure and reduced sperm quality, especially in terms of sperm motility and DNA integrity. Despite some variations in the findings for sperm concentration and morphology, there is sufficient evidence to support the toxicity of pesticides on male reproductive health.
Editorial Material
Environmental Sciences
Colin L. Soskolne, Lisa A. Bero, Shira Kramer, Michael Gochfeld, Juan Pablo Ramos-Bonilla, Jennifer Sass, Carl F. Cranor, Shailesh Advani, Daniele Mandrioli
Summary: This study presents a Toolkit for detecting misused epidemiological methods and proposes suggestions for its modification. The suggestions include rearranging the Toolkit, expanding or adapting it to other disciplines, and using visual representation to assess the Toolkit items. The authors recommend incorporating the Toolkit into forensic epidemiology and its application in graduate training, continuing education, and conferences. Feedback from the research community is welcomed.
ENVIRONMENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Federica Gnudi, Simona Panzacchi, Eva Tibaldi, Martina Iuliani, Daria Sgargi, Luciano Bua, Daniele Mandrioli
Summary: This study reports the carcinogenic effects of aspartame on haemolymphoreticular neoplasias in rats and mice. The analysis was conducted using internationally recommended statistical and pathological methods, confirming the previous findings.
ANNALS OF GLOBAL HEALTH
(2023)
Letter
Public, Environmental & Occupational Health
Giovanni Brandi, Kurt Straif, Daniele Mandrioli, Stefania Curti, Stefano Mattioli, Simona Tavolari
Summary: This commentary reviews and integrates available epidemiological and mechanistic evidence to support the potential role of asbestos exposure in the etiology of intrahepatic cholangiocarcinoma (iCCA).
ANNALS OF GLOBAL HEALTH
(2022)
Article
Environmental Sciences
Robin Mesnage, Maxime Teixeira, Daniele Mandrioli, Laura Falcioni, Quinten Raymond Ducarmon, Romy Danielle Zwittink, Francesca Mazzacuva, Anna Caldwell, John Halket, Caroline Amiel, Jean-Michel Panoff, Fiorella Belpoggi, Michael Nicolas Antoniou
Summary: The study demonstrates that glyphosate and its formulation Roundup MON 52276 can inhibit the shikimate pathway in the rat gut microbiome, with limited physiological consequences. Glyphosate treatment is associated with oxidative stress, while MON 52276 shows more pronounced effects on serum metabolites.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)