The Membrane Interaction of Alpha-Synuclein

Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores

(2020) Debasis Das et al.   Nature Communications

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

(2020) Ersoy Cholak et al.   FASEB JOURNAL

α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate

(2020) Meir Schechter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical studies of membrane fusion at the single-particle level

(2019) Zhiqi Tian et al.   PROGRESS IN LIPID RESEARCH

Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations

(2019) Brenden J. D. Hawk et al.   Frontiers in Neuroscience

Synapsins regulate α-synuclein functions

(2019) Merav Atias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

(2019) Jichao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic vesicle fusion: today and beyond

(2019) Nils Brose et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties

(2018) Huan Bao et al.   NATURE

Interplay between α-synuclein amyloid formation and membrane structure

(2018) Emma I. O'Leary et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Soluble α-synuclein facilitates priming and fusion by releasing Ca2+ from the thapsigargin-sensitive Ca2+ pool in PC12 cells

(2018) Chien-Chang Huang et al.   JOURNAL OF CELL SCIENCE

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation

(2017) Chen Hou et al.   Frontiers in Molecular Neuroscience

Ca2+is a key factor in α-synuclein-induced neurotoxicity

(2016) Plamena R. Angelova et al.   JOURNAL OF CELL SCIENCE

SNARE-mediated membrane fusion in autophagy

(2016) Yongyao Wang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Versatile Structures of α-Synuclein

(2016) Chuchu Wang et al.   Frontiers in Molecular Neuroscience

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

(2016) Giuliana Fusco et al.   Scientific Reports

α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles

(2015) Anthony R. Braun et al.   BIOPHYSICAL JOURNAL

Dopamine transporter activity is modulated by α-synuclein.

(2015) Brittany Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease

(2015) Ting Wang et al.   Frontiers in Neuroscience

Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding

(2014) Ying Lai et al.   BIOCHEMISTRY

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Alpha-Synuclein Function and Dysfunction on Cellular Membranes

(2014) David Snead et al.   Experimental Neurobiology

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission

(2011) AbdulRasheed A. Alabi et al.   Annual Review of Physiology

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter

(2011) Jarod Swant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Sensing by Amphipathic Helices

(2011) Martin Borch Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants

(2009) Jason D. Perlmutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane fusion

(2008) William Wickner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY