Review
Cell Biology
Sung-Min Hwang, Ji Yeon Lee, Chul-Kyu Park, Yong Ho Kim
Summary: Neurodegenerative diseases (NDs) primarily affect neurons and glial cells in the brain, with risk factors and pathophysiological mechanisms not fully understood. Homeostasis of intracellular Ca2+ concentration and pH is crucial for cell function, with TRP channels and PMCA playing vital roles in modulating ionic homeostasis. Dysfunctions of TRP channels and PMCA disrupt neuronal homeostasis under pathological conditions, resulting in various NDs. This review highlights their potential as novel targets for treating NDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Wei Meng, Hongbo Ye, Zhifang Ma, Lei Liu, Tianci Zhang, Qiaoyi Han, Zehong Xiang, Yu Xia, Yue Ke, Xinghua Guan, Qiang Shi, Fazly I. Ataullakhanov, Mikhail Panteleev
Summary: In this study, a perfluorocarbon-based artificial oxygen nanocarrier was constructed to alleviate hypoxia and ischemia-reperfusion injury caused by stroke. The nanocarrier showed high oxygen solubility and anti-thrombotic properties, as well as upregulation of antioxidant molecular pathway. This strategy provides a simple, safe, and effective approach for oxygen delivery to alleviate various pathological responses induced by stroke.
Article
Pharmacology & Pharmacy
Yile Cao, Lei Yang, Hong Cheng
Summary: This study found that Ginkgolide B (GB) can inhibit neuronal apoptosis and reduce neurological damage caused by ischemic stroke by enhancing AMPK activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Summary: In mice consuming a Western diet, genetic ablation of the mitochondrial Mg2+ channel Mrs2 prevents weight gain and promotes metabolism, leading to decreased fat accumulation in the liver and browning of white adipose. Mrs2 deficiency restrains citrate efflux from the mitochondria, making it unavailable to support de novo lipogenesis. Lowering mMg2+ promotes metabolism and dampens diet-induced obesity and metabolic syndrome.
Article
Biochemistry & Molecular Biology
Ravichandran Rakesh, Loganathan Chandramani PriyaDharshini, Kunnathur Murugesan Sakthivel, Rajan Radha Rasmi
Summary: Autophagy is a significant mechanism related to cellular stress, metabolism, and cancer, but its role in cancer is still not well understood. Autophagy involves modifications of various proteins and pathways and is influenced by the interaction between tumor cells and their microenvironment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Chien-Wei Lee, Hui-Chu Lin, Belle Yu-Hsuan Wang, Amanda Yu-Fan Wang, Rita Lih-Ying Shin, Stella Yee Lo Cheung, Oscar Kuang-Sheng Lee
Summary: The study demonstrated the therapeutic effects of Ginkgolide B (GB) on osteoporosis by regulating bone cell balance, promoting osteoblast formation, and inhibiting osteoclast generation. GB significantly improved bone mass in aged mouse models and regulated signaling pathways associated with ROS.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, Research & Experimental
Xinyi Huang, Yili Zhang, Baoyu Qi, Kai Sun, Ning Liu, Bin Tang, Shengjie Fang, Liguo Zhu, Xu Wei
Summary: Hypoxia is a characteristic feature of many diseases, and HIF-1 alpha plays a crucial role in regulating the body's response to hypoxia and maintaining homeostasis. Understanding the complex functions and regulation of HIF-1 alpha could lead to the development of targeted therapies for related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Justin J. Lee, Jawad Alzamil, Saba Rehman, Wanling Pan, Henrik Dimke, R. Todd Alexander
Summary: Activation of the basolateral calcium sensing receptor (CaSR) increases claudin-14 expression in the renal tubular thick ascending limb (TAL), leading to reduced paracellular calcium permeability and increased urinary Ca2+ excretion. This process involves signaling through PLC-stimulated p38 pathway and inhibition of Sp1-mediated repression.
Article
Nanoscience & Nanotechnology
Jing-Wen Cui, Hui-Cong Feng, Chang Xu, Ding-Yuan Jiang, Kai-Hua Zhang, Na-Na Gao, Yuan Wang, He Tian, Chang Liu
Summary: Platelet-derived nanoparticles loaded with ginkgolide B (GB) were developed to counteract oxidative stress, inflammation, and ferroptosis in stroke patients, improving motor recovery.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Lijuan Huang, Yijie Shi, Liang Zhao
Summary: The study found that GB can significantly improve the learning and memory ability of VD rats by reducing TLR4/NF-kappa B mediated neuroinflammation, suggesting that GB may be a potential drug for amelioration of learning and memory impairment in rats with VD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jing Chen, Zhijie Ou, Tiantian Gao, Yuwei Yang, Anmei Shu, Huiqin Xu, Yuping Chen, Zhiyang Lv
Summary: This study found that Ginkgolide B (GB), an active ingredient in Ginkgo biloba extract, may improve diabetic nephropathy (DN) by inhibiting GPX4 ubiquitination and alleviating oxidative stress and ferroptosis in mouse podocytes and DN mice. These findings suggest that GB may be an effective therapeutic option for DN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Linlin Zhang, Jingyi Qi, Xu Zhang, Xiya Zhao, Peng An, Yongting Luo, Junjie Luo
Summary: Mitochondria are essential for cellular energy metabolism and the generation of oxygen free radicals, and also play a crucial role in cell death. Ca2+ acts as a messenger for cell proliferation and death, and is involved in the energy metabolism, physiology, and pathology of mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
H. O. N. G. B. I. N. LIU, Q. I. N. Y. U. N. LiI, X. I. A. O. D. A. N. ZHANG, Y. U. N. Shi, J. I. N. Y. I. LiI
Summary: The study demonstrated that Ginkgolide K (GK) has neuroprotective effects by regulating the expression of mitochondrial calcium uniporter (MCU), preventing apoptosis and potentially offering a promising strategy for treating Alzheimer's disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Cell Biology
Grant C. C. Walters, Yuriy M. M. Usachev
Summary: Mitochondria play essential roles in cellular function, including ATP synthesis, reactive oxygen species production, calcium buffering, and apoptotic signaling. In neurons, calcium buffering is particularly important for regulating various calcium-dependent functions. Recent discoveries of molecular components involved in mitochondrial calcium transport have shed light on the roles of mitochondrial calcium regulation in neuronal function and its implications in neurological diseases. This review discusses the multiple roles of mitochondrial calcium uptake and release mechanisms in normal neuronal function and provides insight into the calcium-dependent mechanisms underlying mitochondrial dysfunction in neurological diseases. The targeting of calcium uptake and release mechanisms could potentially lead to novel therapeutic strategies for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Ruizhou Liu, Zhendong Liu, Hui Chen, Shiping He, Shihan Wang, Jihang Dai, Xiaolei Li
Summary: This study aimed to determine and verify the therapeutic effect of Ginkgolide K (GK) on osteoarthritis (OA) and investigate its mechanism of action. In vivo and in vitro experiments showed that GK promoted the production of major components of the cartilage extracellular matrix and inhibited apoptosis of OA chondrocytes through the activation of hypoxia-inducible factor 1 alpha via the hypoxia signaling pathway. GK has a therapeutic effect on OA and has the potential to be developed into a new drug for OA treatment.
PHYTOTHERAPY RESEARCH
(2023)
Article
Environmental Sciences
Rui Liu, Mingze Tian, Wei Shang, Jiahao Cui, Dan Zhao, Shejiang Liu, Yingxin Zhao, Hui Ding, Jianfeng Fu
Summary: This study investigates the catalytic oxidation of toluene using TiO2-supported noble metal catalysts. The results show that 1 wt%Pt/TiO2 catalyst achieves a toluene conversion rate of 65% even at room temperature (25 degrees C). The uniform dispersion of Pt nanoparticles, abundant surface adsorbed oxygen species, and strong interaction between Pt and TiO2 are found to favor toluene degradation at normal temperature.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Engineering, Chemical
Rui Liu, Shejiang Liu, Hui Ding, Dan Zhao, Jianfeng Fu, Yuxin Zhang, Wangchen Huo, Gang 'Kevin' Li
Summary: The article presents an efficient strategy for the complete decomposition of toluene at normal temperature by constructing a highly dispersed Pt/FeOx catalyst to synergistically ozonate the aromatics. Through a comprehensive experimental study, it was found that atomically dispersed Pt-(OH)(x)(O)-Fe are the active sites for catalytic ozonation of toluene over the Pt/FeOx catalysts. This work enables the destruction of aromatic VOCs at near-ambient conditions in an economical and energy-efficient manner.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Biochemical Research Methods
Shiming Yang, Yaping Zhou, Xiangxin Zhang, Lu Wang, Jianfeng Fu, Xiaotong Zhao, Liu Yang
Summary: This study identified 7 autophagy-related lncRNAs with significant clinical prognostic value in HCC patients, suggesting they could serve as promising therapeutic targets.
BMC BIOINFORMATICS
(2021)
Article
Computer Science, Hardware & Architecture
Ce Shi, Jianfeng Fu, Chengmin Wang, Jie Yan
Summary: This paper introduces a new combinatorial configuration for describing locating arrays, effectively constructs locating arrays with prescribed properties, and obtains upper bounds on the size of locating arrays with small number of factors.
IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES
(2021)
Article
Oncology
Tao Hu, Chao Zhou, Jinjin Jiang, Meili Xu, Huaqin Liu, Chunyan Zhang, Xiaozhi Liu, Jianfeng Fu, Xiaolin Xiao
Summary: Sevoflurane promotes cell proliferation, migration, and invasion in esophageal adenocarcinoma, and reduces sensitivity to cisplatin, while it has no effect on esophageal squamous cell carcinoma behavior.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Anesthesiology
Guangquan An, Guiying Wang, Bingsha Zhao, Xiaoying Zhang, Zhihan Li, Jianfeng Fu, Xuelian Zhao
Summary: This study suggests that opioid-free anesthesia can achieve an effective analgesia-antinociception balance in laparoscopic radical colectomy. The use of non-opioid anesthesia reduces the need for additional analgesics after surgery. Although blood glucose levels increase with opioid-free anesthesia, the incidence of opioid-related adverse reactions is not significantly different compared to opioid-based anesthesia.
BMC ANESTHESIOLOGY
(2022)
Article
Engineering, Geological
Hao Kou, Chuan He, Wenbo Yang, Fangyin Wu, Zihan Zhou, Jianfeng Fu, Longge Xiao
Summary: This study derived a simple nonlinear damage creep model based on fractional order theory to describe the time-dependent creep characteristics of transversely isotropic rock. Triaxial creep tests were conducted on phyllite specimens with different bedding angles, and significant differences were observed in creep deformation and failure characteristics. The accuracy and rationality of the model were verified by comparing it with experimental data and other models.
ROCK MECHANICS AND ROCK ENGINEERING
(2023)
Article
Polymer Science
Chenglong Dai, Dan Zhao, Yongqiang Wang, Rui Zhao, Han Wang, Xiangci Wu, Shejiang Liu, Huizhen Zhu, Jianfeng Fu, Mengling Zhang, Hui Ding
Summary: This paper investigates the influence of doping graphene oxide (GO) nanoparticles to the active layer and support layer of thin-film composite forward osmosis (TFC-FO) membranes. The results show that doping GO improves the salt rejection and water permeability of the membrane, forming dense and uniform nano-scale water channels.
Review
Biochemistry & Molecular Biology
Rui Zhao, Han Wang, Dan Zhao, Rui Liu, Shejiang Liu, Jianfeng Fu, Yuxin Zhang, Hui Ding
Summary: This review systematically summarizes recent progress on the catalytic oxidation of VOCs at ambient temperature. The structure-activity relationship in the catalytic oxidation process can be influenced by adjusting the structure of nanoparticle catalysts, cluster catalysts, and single-atom catalysts. The catalytic activity is also affected by process conditions. Currently, ambient temperature catalytic oxidation is mainly used for the removal of easily degradable pollutants, and there is a need to improve the activity, selectivity, and stability of catalysts. New prospects and challenges are proposed based on the existing problems and limitations in the application of ambient temperature catalytic oxidation technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Chemical
Han Wang, Rui Zhao, Dan Zhao, Shejiang Liu, Jianfeng Fu, Yuxin Zhang, Nan Dai, Dan Song, Hui Ding
Summary: This review systematically explains the main pathways and influencing factors of greenhouse gas emissions from farmland soil, and focuses on the microbial mechanisms of soil greenhouse gas emissions under soil remediation modes.
Article
Green & Sustainable Science & Technology
Xuehao Zheng, Belay Tafa Oba, Han Wang, Bin Zhang, Chengqiang Shu, Yan Song, Jianfeng Fu, Shejiang Liu, Yuxin Zhang, Nan Dai, Dan Song, Hui Ding
Summary: This study conducted a comprehensive bibliometric analysis of organo-mineral complexes (OMCs) and predicted future research directions. The research identified potential applications of OMCs in agriculture and pollutant control. This report, for the first time, used bibliometrics to clarify the research gap and highlight the importance of OMCs research.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Geological
Pan Wen-tao, Yang Wen-bo, Wu Fang-yin, He Chuan, Zhao Liang-liang, Yao Ren-jie, Fu Jian-feng
Summary: In this study, the optimal simulation ratio, film porosity for simulating bedding adhesion, and mechanical properties of samples with different bedding angles and thickness were determined through indoor tests. The results showed that barite powder played a crucial role in the strength and failure deformation of soft rock, the film with 30% porosity had the best effect in simulating bedding, and the strength of soil samples exhibited a U-shape with the layer angle and decreased with the decrease of layer thickness.
ROCK AND SOIL MECHANICS
(2022)
Article
Medicine, General & Internal
Tao Hu, Yunfeng Niu, Jianfeng Fu, Zhiming Dong, Dongwei He, Junfeng Liu
Summary: The study found that PCNA-AS1 is highly expressed in esophageal squamous cell carcinoma and is associated with patient prognosis. It can promote tumor cell proliferation, invasion, and migration, and upregulate PCNA expression through a competitive endogenous RNA mechanism.