Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

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Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

(2015) Huimei Yu et al.   NATURE NEUROSCIENCE

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

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Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation

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Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

(2012) Miao Yu et al.   CELL

Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors

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Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

(2012) Liang Zhang et al.   Nature Chemical Biology

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

Identifying ChIP-seq enrichment using MACS

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Unraveling the Glioma Epigenome-From Molecular Mechanisms to Novel Biomarkers and Therapeutic Targets

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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

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Differential DNA Methylation Alterations in Radiation-Sensitive and -Resistant Cells

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Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

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Stable Brain ATM Message and Residual Kinase-Active ATM Protein in Ataxia-Telangiectasia

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Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

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5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

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Genomic mapping of 5-hydroxymethylcytosine in the human brain

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells

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BEDTools: a flexible suite of utilities for comparing genomic features

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The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Mitochondrial Dysfunction in NnaD Mutant Flies and Purkinje Cell Degeneration Mice Reveals a Role for Nna Proteins in Neuronal Bioenergetics

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Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

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Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

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