Unraveling the Glioma Epigenome-From Molecular Mechanisms to Novel Biomarkers and Therapeutic Targets

SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation

(2011) Carina Lindemann et al.   ACTA NEUROPATHOLOGICA

Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression

(2011) Martin Hasselblatt et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Nucleosome Structure(s) and Stability: Variations on a Theme

(2011) Andrew J. Andrews et al.   Annual Review of Biophysics

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Epigenetics in Alternative Pre-mRNA Splicing

(2011) Reini F. Luco et al.   CELL

Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming

(2011) Yufeng Li et al.   CELL RESEARCH

Readers of histone modifications

(2011) Miyong Yun et al.   CELL RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Advances in DNA methylation: 5-hydroxymethylcytosine revisited

(2011) Christina Dahl et al.   CLINICA CHIMICA ACTA

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

(2011) Jörg Felsberg et al.   INTERNATIONAL JOURNAL OF CANCER

DNA Methylation and Demethylation in Mammals

(2011) Zhao-xia Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in X-chromosome inactivation

(2011) Sundeep Kalantry   JOURNAL OF CELLULAR PHYSIOLOGY

TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations

(2011) Y.-H. Kim et al.   JOURNAL OF CLINICAL PATHOLOGY

Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas

(2011) Ganeshkumar Rajendran et al.   JOURNAL OF NEURO-ONCOLOGY

Histone Chaperones: Modulators of Chromatin Marks

(2011) Nikita Avvakumov et al.   MOLECULAR CELL

Epigenetic regulation of microRNAs in cancer: An integrated review of literature

(2011) Tanja Kunej et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

A multigene predictor of outcome in glioblastoma

(2011) H. Colman et al.   NEURO-ONCOLOGY

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma

(2011) M. Weller et al.   NEUROLOGY

The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma

(2011) Fumiharu Ohka et al.   PLoS One

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

(2011) C. Bettegowda et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Molecular diagnostics of gliomas: state of the art

(2010) Markus J. Riemenschneider et al.   ACTA NEUROPATHOLOGICA

Non-coding RNAs and their epigenetic regulatory mechanisms

(2010) Huihui Zhou et al.   BIOLOGY OF THE CELL

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Global Histone Modification Patterns as Prognostic Markers to Classify Glioma Patients

(2010) B.-l. Liu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma

(2010) B. M. Costa et al.   CANCER RESEARCH

Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas

(2010) Benito Campos et al.   CANCER SCIENCE

IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

(2010) M. J. van den Bent et al.   CLINICAL CANCER RESEARCH

Epigenomics of centromere assembly and function

(2010) Kaitlin M Stimpson et al.   CURRENT OPINION IN CELL BIOLOGY

Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer

(2010) Armelle Corpet et al.   EMBO JOURNAL

Nucleosome dynamics and epigenetic stability

(2010) Philipp Korber et al.   Essays in Biochemistry

Retrospective protein expression and epigenetic inactivation studies of CDH1 in patients affected by low-grade glioma

(2010) Pietro Ivo D’Urso et al.   JOURNAL OF NEURO-ONCOLOGY

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma

(2010) Brock C. Christensen et al.   JNCI-Journal of the National Cancer Institute

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas

(2010) B.-L. Liu et al.   NEURO-ONCOLOGY

Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis

(2010) J. Laffaire et al.   NEURO-ONCOLOGY

The DNA methylome of glioblastoma multiforme

(2010) Ramon Martinez et al.   NEUROBIOLOGY OF DISEASE

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

(2010) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

MGMT promoter methylation in malignant gliomas

(2010) Markus J. Riemenschneider et al.   Targeted Oncology

Genome-scale DNA methylation analysis

(2010) Shaun D Fouse et al.   Epigenomics

ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma

(2009) Silke Götze et al.   BMC CANCER

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

(2009) Wolfgang Wick et al.   JOURNAL OF CLINICAL ONCOLOGY

Chk2 down-regulation by promoter hypermethylation in human bulk gliomas

(2009) Hongwei Wang et al.   LIFE SCIENCES

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

(2009) Michael Weller et al.   Nature Reviews Neurology

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The multi-domain protein Np95 connects DNA methylation and histone modification

(2009) Andrea Rottach et al.   NUCLEIC ACIDS RESEARCH

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells

(2008) Roberto Papait et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

(2008) Agda KB Lucio-Eterovic et al.   BMC CANCER

RASSF1A,BLU, NORE1A,PTENandMGMTExpression and Promoter Methylation in Gliomas and Glioma Cell Lines and Evidence of Deregulated Expression ofde novo DNMTs

(2008) Aiala Lorente et al.   BRAIN PATHOLOGY

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

Frequent promoter hypermethylation and transcriptional downregulation of theNDRG2gene at 14q11.2 in primary glioblastoma

(2008) Martin Tepel et al.   INTERNATIONAL JOURNAL OF CANCER

Frequent biallelic inactivation and transcriptional silencing of theDIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss

(2008) Markus J. Riemenschneider et al.   INTERNATIONAL JOURNAL OF CANCER

MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples

(2008) Marcus Bettstetter et al.   LABORATORY INVESTIGATION

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

(2008) D Mottet et al.   ONCOGENE

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE