Review
Medicine, Research & Experimental
Anastasios G. Konstas, Leopold Schmetterer, Andreas Katsanos, Cindy M. L. Hutnik, Gabor Hollo, Luciano Quaranta, Miguel A. Teus, Hannu Uusitalo, Norbert Pfeiffer, L. Jay Katz
Summary: This review discusses the clinical attributes of preserved dorzolamide/timolol fixed combination (DTFC) and the potential of preservative-free (PF) DTFC based on published evidence and clinical experience. DTFC is the first FDA-approved intraocular pressure-lowering fixed combination and remains widely used globally. The pharmacological properties of DTFC are reflective of its constituents, dorzolamide and timolol, and studies have shown its efficacy in lowering IOP. PF DTFC has been shown to be at least as effective as preserved DTFC, providing clinical benefits for glaucoma patients with ocular surface disease. Further research is needed to explore the full potential of both preserved and PF DTFC.
ADVANCES IN THERAPY
(2021)
Article
Pharmacology & Pharmacy
Claudia Veloso, Romeu A. Videira, Paula B. Andrade, Catarina Cardoso, Carla Vitorino
Summary: The combination of multiple active pharmaceutical ingredients in a fixed-dose combination product for topical administration shows potential in treating various pathologies, including pain. This study presents information on accepted in vitro tests for assessing the safety of topical products and the commonly used methods for evaluating anti-inflammatory activity. Additionally, a new approach for selecting fixed-dose combination products to enhance therapeutic effects is rationalized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Astronomy & Astrophysics
Rajesh Biswas, Asaad Daher, Arpan Das, Wojciech Florkowski, Radoslaw Ryblewski
Summary: We numerically solve the boost-invariant equations of spin hydrodynamics confined to the first-order terms in gradients. The spin equation of state is consistently included in the first order, which relates the spin density tensor to the spin chemical potential. Depending on the form and structure of the spin transport coefficients, we find solutions that are both stable and unstable within the considered evolution times of 10 fm/c. These findings complement the recent identification of stable and unstable modes for perturbed uniform spin systems described by similar hydrodynamic frameworks.
Article
Pharmacology & Pharmacy
Agata Gorniak, Adrianna Zlocinska, Mateusz Trojan, Adrianna Pecak, Bozena Karolewicz
Summary: The simvastatin-ezetimibe solid dispersion prepared using the co-grinding method showed improved dissolution of ezetimibe regardless of simvastatin content. The study also confirmed a simple eutectic phase equilibrium diagram between simvastatin and ezetimibe.
Article
Pharmacology & Pharmacy
Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Abayomi Mayowa Ajayi, Olalekan Ayodele Agede, Sunday Sokunle Soyemi, Alban Ikenna Mgbehoma, Ikechukwu Innocent Okoye, Ralph M. Albrecht, James Mukasa Ntambi, Peter Anthony Crooks
Summary: This study unveiled the promising therapeutic potentials of amlodipine, lisinopril, valsartan, and their fixed-dose combinations in the management of TZM cardiotoxicity, majorly mediated via antiapoptotic and oxidative stress inhibition mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Claudia Veloso, Romeu A. Videira, Paula B. Andrade, Catarina Cardoso, Carla Vitorino
Summary: This article discusses the application of fixed-dose combination products in pain management and emphasizes the role of animal models in evaluating the efficacy and safety of these formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Thermodynamics
Agata Gorniak, Hanna Czapor-Irzabek, Adrianna Zlocinska, Bozena Karolewicz
Summary: The study demonstrated that the solid dispersions of ezetimibe and aspirin prepared in this work can release the drugs more quickly, proving the effectiveness of this formulation in enhancing drug dissolution.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Chemistry, Analytical
Katarina Dubayova, Kristina Krajcikova, Maria Marekova, Vladimira Tomeckova
Summary: This study analyzed tear fluid using three-dimensional synchronous fluorescence spectroscopy, presenting a novel strategy to distinguish between healthy subjects and glaucoma patients. The approach of processing synchronous excitation spectra provides useful parameters for enhancing the differentiation between tear fluids of different groups.
Article
Chemistry, Medicinal
Claudia Veloso, Catarina Cardoso, Carla Vitorino
Summary: Pain is a severe public health problem, and combining active pharmaceutical ingredients with multiple mechanisms of action may be more effective than traditional monotherapy. Topical drug delivery has advantages such as high efficacy, better safety profile, and good patient compliance. Fixed-dose combinations for topical administration could be a promising therapeutic option for pain management.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sang-Jun Cho, In-Sun Oh, Han Eol Jeong, Young Min Cho, Yul Hwangbo, Oriana Hoi Yun Yu, Ju-Young Shin
Summary: This study compared the treatment patterns and clinical outcomes of single-pill fixed-dose combination (FDC) therapy and two-pill combination (TPC) therapy in patients with type 2 diabetes using real-world data from South Korea. The results showed that FDC therapy had better medication adherence and was associated with a reduced risk of cardiovascular events, particularly stroke, and hospitalization.
DIABETES OBESITY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Abdulmajeed A. Althobaiti, Eman A. Ashour, Ahmed Almotairy, Mashan Almutairi, Mohammed AlYahya, Michael A. Repka
Summary: This study aimed to design and develop different dosage forms of nifedipine/indomethacin fixed-dose combination (FDC) to provide delayed-extended and immediate release profiles. The developed FDC dosage forms showed significant improvement in drug release profiles and remained stable during the stability study. These designed dosage forms could enhance patient compliance and improve the quality of life.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Wei-Chun Huang, Chih-Yu Chen, Wei-Chih Liao, Biing-Ru Wu, Wei-Chun Chen, Chih-Yen Tu, Chia-Hung Chen, Wen-Chien Cheng
Summary: This study evaluated the efficacy of once-daily long-acting beta 2-agonist/long-acting muscarinic antagonist fixed-dose combinations for improving lung function in patients with chronic obstructive pulmonary disease (COPD). The results showed that all three treatment options significantly increased the forced expiratory volume in 1 s (FEV1), and treatment with tiotropium/olodaterol resulted in significant improvement in forced vital capacity (FVC%) and residual volume (RV%).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Jeeyoung Kwak, Jong Hwa Jun
Summary: This study reported a case of acute corneal endothelial decompensation caused by the use of topical DTFC after Descemet stripping automated endothelial keratoplasty. The symptoms improved gradually after discontinuing the medication.
Article
Pharmacology & Pharmacy
Suha M. Dadou, Yiwei Tian, Shu Li, David S. Jones, Gavin P. Andrews
Summary: This study developed predictive inline Process Analytical Technology (PAT) tools for simultaneous quantification of two antihypertensive drugs during continuous manufacture of Fixed-dose combinations (FDCs). The established models showed excellent linearity, selectivity, and accuracy, demonstrating the potential of chemometrics and Raman spectroscopy for in-process quality control of complex formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Health Policy & Services
Laila Carolina Abu Esba, Consuela Yousef, Sherine Ismail, Murtada Halim, Hind Almodaimegh, Hana Abdullah Al-Abdulkarim, Mansour Alhowimel
Summary: Determining whether a fixed-dose combination (FDC) is beneficial to a healthcare organization requires a comprehensive consideration of evidence, practicality, and cost.
HEALTH POLICY AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sakshi Khairnar, Divya D. Jain, Srushti M. Tambe, Yashashri R. Chavan, Purnima D. Amin
Summary: Drug delivery via the pulmonary route offers many benefits and is suitable for various patients. Recent advances in research and technology have opened up new possibilities and opportunities for inhaled drug delivery.
THERAPEUTIC DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Y. R. Chavan, S. M. Tambe, S. V. Khairnar, P. D. Amin
Summary: The limitations of non-biodegradable polymers have led to the development of biodegradable polymers in pharmaceutical and biomedical sciences. Poly (lactic-co-glycolic acid) (PLGA) is a successful biodegradable polymer with favorable properties such as biodegradability, biocompatibility, controllable drug release profile, and surface modification capabilities.
ANNALES PHARMACEUTIQUES FRANCAISES
(2022)
Article
Materials Science, Paper & Wood
Divya D. Jain, Srushti M. Tambe, Purnima D. Amin
Summary: The aim of this study was to develop sustained-release mini-matrices of tramadol hydrochloride using hot-melt extrusion (HME) process. By using the Design of Experiment (DoE) method, a feasible formulation window with the desired quality target product profile was successfully developed by determining the ratios of hydrophobic and hydrophilic components, as well as the processing temperature. FTIR chemical imaging, SEM analysis, and FTIR results confirmed the homogeneous drug distribution and drug-matrix interaction. Hydroalcoholic dissolution studies demonstrated safe and sustained-release of tramadol. The developed mini-matrices followed the Peppas-Sahlin model, indicating a combination of Fickian diffusion and swelling mechanisms.
Article
Pharmacology & Pharmacy
Juber Pendhari, Hemali Savla, Durga Bethala, Shashikant Vaidya, Ujwala Shinde, Mala Menon
Summary: In recent years, mitochondria have been recognized as an important target for cancer treatment. Studies have shown that delivering metformin hydrochloride (MET) through mitochondria-targeted liposomes can enhance its anticancer activity. This study successfully developed mitochondria-targeted liposomes of MET and demonstrated their potential for improving cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Srutee Rout, Srushti Tambe, Ram Kumar Deshmukh, Suraj Mali, Jorddy Cruz, Prem Prakash Srivastav, Purnima D. Amin, Kirtiraj K. Gaikwad, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira
Summary: This review discusses the application of essential oils (EOs) in food preservation and shelf-life augmentation. EOs have antimicrobial properties and can protect the quality of food matrices. Encapsulation and nano-encapsulation techniques can overcome the limitations of EOs in water solubility, volatility, and stability. Smart packaging systems are also proposed to extend the shelf life of food products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Srushti Tambe, Divya Jain, Sai Kishore Meruva, Gopinath Rongala, Abhishek Juluri, Girish Nihalani, Hemanth Kumar Mamidi, Pavan Kumar Nukala, Pradeep Kumar Bolla
Summary: Amorphous solid dispersions (ASDs) are widely studied techniques for enhancing solubility. The formulation development of ASDs has progressed significantly since the 1960s, with advancements in preparation methods and characterization techniques. Multiple carriers and plasticizers are now used to improve the stability and performance of ASDs. Modern techniques such as nano-tomography and transmission electron microscopy aid in understanding the microstructure of ASDs.
Review
Biotechnology & Applied Microbiology
Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta
Summary: Flavonoids, a major group of polyphenolic compounds, have shown significant potential in inhibiting tumor proliferation, cell cycle, angiogenesis, migration, and invasion in lung cancer. However, their clinical application is limited due to poor solubility, low permeability, and quick blood clearance. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers, and nanotubes can greatly enhance the targeted action of flavonoids with improved efficacy and pharmacokinetic properties, making them suitable for treating lung cancer. This review highlights the therapeutic potential of flavonoids and the cutting-edge progress in nanoengineered systems incorporating flavonoids for lung cancer treatment.
Review
Biotechnology & Applied Microbiology
Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta
Summary: Lung cancer is a major cause of cancer-related deaths worldwide, and non-small-cell lung cancer is the most common type. Nanotechnology-based drug-delivery systems show great potential in lung cancer therapy due to their unique characteristics. However, traditional chemotherapeutics have toxicity issues, so polyphenols from diet could be used as a replacement. Targeted nanotherapeutics based on polyphenols have shown interactions with protein targets and cellular signaling pathways, affecting key cellular processes. This review summarizes the molecular mechanisms and targeted therapeutic potentials of nanoengineered dietary polyphenols in lung cancer management.
Editorial Material
Chemistry, Medicinal
Srushti Tambe, Kavindra Kumar Kesari, Yogendra Kumar Mishra, Purnima Amin, Sabya Sachi Das
FUTURE MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Kiran Shahane, Madhuri Kshirsagar, Srushti Tambe, Divya Jain, Srutee Rout, Maria Karolina Martins Ferreira, Suraj Mali, Purnima Amin, Prem Prakash Srivastav, Jorddy Cruz, Rafael Rodrigues Lima
Summary: Calendula officinalis Linn. is a popular medicinal plant with multifaceted biological effects, including anti-inflammatory, anti-cancer, antidiabetes, and wound healing activities. Recent research has explored its therapeutic applications, molecular mechanisms, and clinical studies, providing possibilities for validating traditional claims and advancing its safe and effective use.
Article
Pharmacology & Pharmacy
Srushti M. Tambe, Divya D. Jain, Chetan Hasmukh Mehta, T. Ashwini, Usha Yogendra Nayak, Purnima D. Amin
Summary: In this study, a novel ophthalmic solution called MeltDrops was successfully developed using hot-melt extrusion technology. MeltDrops showed improved retention time and bioavailability compared to marketed eyedrops. It also exhibited better physical and chemical uniformity and sustained drug release for over 12 hours in vitro. In vivo studies in rabbits confirmed the superior effectiveness and safety of MeltDrops.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Spectroscopy
Zh. E. Ozbekova, A. A. Abdyldaev, A. A. Kulmyrzaev
Summary: This study compared two drying methods for cow and yak muscles, finding that freeze drying caused less discoloration. Additionally, analysis of fluorescence spectra allowed for accurate prediction of chemical composition and color characteristics of the muscles.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Leo Mandic, Ivan Ljubic, Iva Dzeba
Summary: In this study, a combined experimental and computational approach was used to investigate the photoexcitation and photodegradation mechanisms of Doxazosin (DOX). The results provide valuable insights into the primary events following the photoexcitation of DOX and its potential applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Xiufeng Wang, Yao Jin, Wenhui Ai, Siqi Wang, Zhiqing Zhang, Ting Zhou, Fang Wang, Guodong Zhang
Summary: This study successfully synthesized near infrared fluorescence Ag2S quantum dots (QDs) and developed a dual-mode sensor for sulfide anion using the excellent oxidase-like characteristics of manganese dioxide (MnO2) nanosheets. The sensor showed a wider detection range, higher sensitivity, and shorter reaction time, making it suitable for highly selective detection of sulfide in different concentration ranges.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yafei Li, Yanming Ma, Chuantao Zheng, Di Yu, Lien Hu, Shuo Yang, Fang Song, Yadan Li, Shuanghai Liu, Zhanrui Zhang, Yu Zhang, Yiding Wang, Frank K. Tittel
Summary: To effectively monitor gas explosion and coal spontaneous combustion in coal mine, an intrinsically safe and explosion-proof dual-gas sensor system was developed for methane (CH4) and carbon monoxide (CO) measurement. The system achieved different measurement ranges using laser scanning and gas cells, and improved stability and accuracy through gas pre-treatment and temperature compensation algorithm.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Pei-Rong Chen, Li-Kang Chu
Summary: In this study, the hydrates of glyoxal were investigated using infrared absorption spectrometry. The results showed that at low concentrations, glyoxal mainly exists as monomeric dihydrate. These findings provide suitable detection windows for further research on the roles of glyoxal and its hydrates in atmospheric and aerosol chemistry, as well as the relevant reaction kinetics.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Nichole O'Neill, Thamires A. Lima, Fabio Furlan Ferreira, Nicolas J. Alvarez, Reinhard Schweitzer-Stenner
Summary: This study determines the main fibril axis of GHG gel-forming fibrils using various techniques and compares the results with simulated data. The analysis suggests that the hydrophobic xz-surfaces of GHG fibrils could be a good target for the adsorption of hydrophobic drugs.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Mengyuan Liu, Hanchuang Zhu, Yikun Fang, Caiyun Liu, Xinke Li, Xiaohui Zhang, Lixue Ma, Kun Wang, Miaohui Yu, Wenlong Sheng, Baocun Zhu
Summary: ABHS is an efficient fluorescent probe that can accurately and sensitively detect Al3+ with strong resistance to interference. It also demonstrates excellent detection and imaging capabilities in complex real samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Ahmed S. El-Shafie, Evana Rahman, Yasser Gadelhak, Rehab Mahmoud, Marwa El-Azary
Summary: The recycling of waste mandarin peels into biochar (MRBC) has been used as a high performance and cost-effective adsorbent for treating polluted wastewater effluents. Batch adsorption studies were conducted to analyze the adsorption competency of MRBC on two dyes, methylene blue (MB) and basic fuchsin (BF), either in individual solutions or binary combinations. The results showed that MRBC was capable of effectively removing a high percentage of both dyes. However, the adsorption capacity decreased when the dyes were combined. The cost estimation of MRBC production and wastewater treatment indicated that both were relatively low.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Anindita Bhatta, Jahnabi Upadhyaya, Dipak Chamlagai, Lincoln Dkhar, Pynskhemborlang T. Phanrang, Mohan Rao Kollipara, Sivaprasad Mitra
Summary: Derivatives of thiazole-pyrazole fused benzo-coumarin compounds were synthesized and their photophysical properties were investigated. The synthesized coumarin compounds showed potential as therapeutic agents for Alzheimer's disease, inhibiting acetylcholinesterase activity. The presence of human serum albumin was found to affect the inhibition activity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yongwei Duan, Quancheng Liu, Yiju Zhu, Qi Zhang, Xiaohui Duan, Hu Deng, Liping Shang
Summary: In this study, the phase transition of CL-20 was observed using terahertz spectroscopy, and quantum chemical calculations were employed to analyze the vibrations. The results indicated changes in the vibrations of CL-20 before and after phase transition.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yuefeng Gao, Sai Xu, Baojiu Chen
Summary: This study synthesized Cs2NaInCl6 nanocrystals co-doped with Sb3+ and Tb3+ ions as probes for copper ions detection in lubricating oil. The introduction of Sb3+ effectively reduced the band gap of the host material and enabled energy transfer pathway for Tb3+ emission. The doped Tb3+ ions resulted in the suppression of emission due to electron transfer. The Cs2NaInCl6: 2.5 %Sb3+, 40 %Tb3+ NCs exhibited superior sensitivity and selectivity for copper ions detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Yu Liu, Yue Zhang, Changyao Liu, Ce Wang, Baocai Xu, Li Zhao
Summary: A highly sensitive detection platform for heparin was developed using a cationic fluorescent dye (cresyl violet acetate) as a fluorescence probe. The platform demonstrated high selectivity towards heparin and achieved detection in both HEPES solution and serum.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Lopamudra Roy, Nivedita Pan, Susmita Mondal, Ria Ghosh, Md. Nur Hasan, Neha Bhattacharyya, Soumendra Singh, Kallol Bhattacharyya, Arpita Chattopadhyay, Samir Kumar Pal
Summary: The study focuses on the interaction between reactive oxygen species (ROS) and a spectroscopic probe called Rose Bengal (RB), encapsulated in nanoscopic sodium dodecyl sulphate (SDS) micelles and entrapped in microscopic nylon 66 solid matrix. The research demonstrates efficient interaction between ROS and RB-SDS, and investigates the mechanism of hydroxyl radicals generation. Based on these findings, a prototype device utilizing RB embedded in a nylon thin film for quantification of ROS in extracellular fluids and food materials was developed.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Xiaosong Sun, Qihao Cui, Wenyue Dong, Qian Duan, Teng Fei
Summary: Conjugated porous polymers (CPPs) are promising sensing materials and their application in aqueous media is limited. In this study, we synthesized CPPs with porous structure and prepared nanoparticles, enabling efficient photoluminescence sensing of nitroaromatic explosives in aqueous phase.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Spectroscopy
Maria Cristina Caggiani, Germana Barone, Paolo Mazzoleni
Summary: Raman spectroscopy is commonly used for studying glassy materials in cultural heritage, but it is more difficult to interpret the spectra and apply the technique with portable instruments. In contrast, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) can be used in archaeometric investigations as it is portable and non-invasive. However, there is limited application of this technique to historical glasses. This exploratory work demonstrates the potential of DRIFTS, in combination with portable X-ray Fluorescence (pXRF) and EDS microanalyses, for studying the composition and alteration of glass samples in cultural heritage.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)