Lipid presentation by the protein C receptor links coagulation with autoimmunity

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

(2020) Laura Schaupp et al.   CELL

Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity

(2019) William E. Ruff et al.   Cell Host & Microbe

Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis

(2019) Nadine Müller-Calleja et al.   BLOOD

Myeloid cell–synthesized coagulation factor X dampens antitumor immunity

(2019) Claudine Graf et al.   Science Immunology

Induction of tissue factor expression by anti-β2-glycoprotein I is mediated by tumor necrosis factor α

(2019) Anne Hollerbach et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Diagnosis and Management of the Antiphospholipid Syndrome

(2018) David Garcia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiphospholipid syndrome

(2018) Karen Schreiber et al.   Nature Reviews Disease Primers

Regulation of systemic tissue injury by coagulation inhibitors in B6.MRL/lpr autoimmune mice

(2018) C. Moratz et al.   CLINICAL IMMUNOLOGY

Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

(2018) Allison Sang et al.   Nature Communications

Antiphospholipid antibody-induced cellular responses depend on epitope specificity : implications for treatment of antiphospholipid syndrome

(2017) N. Müller-Calleja et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier StabilizationSignificance

(2016) Ranjeet K. Sinha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice

(2016) D. Manukyan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

(2016) Victoria Ulrich et al.   Arthritis & Rheumatology

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

(2015) H. P. H. Liang et al.   BLOOD

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice

(2015) Hai Po H. Liang et al.   BLOOD

A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesicles

(2015) M. Wu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease in antiphospholipid syndrome, systemic lupus erythematosus and antiphospholipid syndrome with lupus

(2014) Carlos Perez-Sanchez et al.   ANNALS OF THE RHEUMATIC DISEASES

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2

(2014) Vincent O. Oninla et al.   JOURNAL OF LIPID RESEARCH

Deletion of the Antiphospholipid Syndrome Autoantigen β2-Glycoprotein I Potentiates the Lupus Autoimmune Phenotype in a Toll-like Receptor 7-Mediated Murine Model

(2014) Bill Giannakopoulos et al.   Arthritis & Rheumatology

Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase

(2013) F. Langer et al.   BLOOD

The Pathogenesis of the Antiphospholipid Syndrome

(2013) Bill Giannakopoulos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development

(2013) Florence Schaffner et al.   PLoS One

Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells

(2011) N. Prinz et al.   BLOOD

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove

(2011) J. Lopez-Sagaseta et al.   BLOOD

Endothelial protein C receptor is required for tissue factor ternary complex signaling in the mouse

(2011) J. DISSE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome

(2010) Z. Romay-Penabad et al.   BLOOD

Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis

(2010) T. A. White et al.   BLOOD

Induction of phospholipid-binding antibodies in mice and rabbits by immunization with human β2 glycoprotein 1 or anticardiolipin antibodies alone

(2010) S. S. PIERANGELI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structural and functional characterization of a human IgG monoclonal antiphospholipid antibody

(2010) Nadine Prinz et al.   IMMUNOBIOLOGY

The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

(2010) Jennifer Disse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome

(2008) Patricia Redecha et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelet activation by dimeric2-glycoproteinI requires signaling via both glycoproteinIb and apolipoproteinE receptor2

(2008) R. T. URBANUS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS