Sequential C–F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts

Frustrated Lewis-Pair-Meditated Selective Single Fluoride Substitution in Trifluoromethyl Groups

(2020) Dipendu Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

(2020) Jeroen B. I. Sap et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Desymmetrization of difluoromethylene groups by C–F bond activation

(2020) Trevor W. Butcher et al.   NATURE

Photoredox-Catalyzed Deaminative Alkylation via C–N Bond Activation of Primary Amines

(2020) Melissa A. Ashley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defluorinative Functionalization of Pd(II) Fluoroalkyl Complexes

(2020) Michael M. Wade Wolfe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Fluorination of carbonyls with nucleophilic fluorine

(2019) Pauline Adler et al.   Nature Chemistry

Boryl Radical Addition to Multiple Bonds in Organic Synthesis

(2019) Tsuyoshi Taniguchi   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective Defluoroallylation of Trifluoromethylarenes

(2019) Chaosheng Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective C–F Functionalization of Unactivated Trifluoromethylarenes

(2019) David B. Vogt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemical C−H Hydroxyalkylation of Quinolines and Isoquinolines

(2019) Bartosz Bieszczad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ketones and aldehydes as alkyl radical equivalents for C─H functionalization of heteroarenes

(2019) Jianyang Dong et al.   Science Advances

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

(2018) Yi Zhu et al.   CHEMICAL REVIEWS

Picking one out of three: selective single C-F activation in trifluoromethyl groups

(2018) Florian Jaroschik   CHEMISTRY-A EUROPEAN JOURNAL

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

(2018) Eric D. Nacsa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

(2018) Jiasong Li et al.   Nature Chemical Biology

Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds

(2018) Rohan R. Merchant et al.   SCIENCE

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

5-Endo Cyclizations of NHC-Boraallyl Radicals Bearing Ester Substituents: Characterization of Derived 1,2-Oxaborole Radicals and Boralactones

(2018) Wen Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrophilicity and Nucleophilicity of Boryl Radicals

(2017) Chao Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

Radical Borylation/Cyclization Cascade of 1,6-Enynes for the Synthesis of Boron-Handled Hetero- and Carbocycles

(2017) Shi-Chao Ren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Defluoroalkylation of Trifluoromethylaromatics with Unactivated Alkenes

(2017) Hengbin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Single C(sp3)–F Bond Cleavage in Trifluoromethylarenes: Merging Visible-Light Catalysis with Lewis Acid Activation

(2017) Kang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Lewis Base–Boryl Radicals Enabled the Desulfurizative Reduction and Annulation of Thioamides

(2017) You-Jie Yu et al.   ORGANIC LETTERS

A catalytic fluoride-rebound mechanism for C(sp3)-CF3bond formation

(2017) Mark D. Levin et al.   SCIENCE

Site-Selective Tertiary Alkyl-Fluorine Bond Formation from α-Bromoamides Using a Copper/CsF Catalyst System

(2016) Takashi Nishikata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single C−F Bond Cleavage of Trifluoromethylarenes with an ortho -Silyl Group

(2016) Suguru Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amine–boranes bearing borane-incompatible functionalities: application to selective amine protection and surface functionalization

(2016) P. Veeraraghavan Ramachandran et al.   CHEMICAL COMMUNICATIONS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Enantioselective aldol reactions with masked fluoroacetates

(2016) Jakub Saadi et al.   Nature Chemistry

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

(2016) Megumi Noshita et al.   ORGANIC LETTERS

Thiyl-Radical-Catalyzed Photoreductive Hydrodifluoroacetamidation of Alkenes with Hantzsch Ester as a Multifunctional Reagent

(2016) Wenhao Huang et al.   ACS Catalysis

Review of recent advances in CF bond activation of aliphatic fluorides

(2015) Qian Shen et al.   JOURNAL OF FLUORINE CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alcohols as alkylating agents in heteroarene C–H functionalization

(2015) Jian Jin et al.   NATURE

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Thiyl Radicals in Organic Synthesis

(2014) Fabrice Dénès et al.   CHEMICAL REVIEWS

Functionalization of Fluorinated Molecules by Transition-Metal-Mediated C–F Bond Activation To Access Fluorinated Building Blocks

(2014) Theresia Ahrens et al.   CHEMICAL REVIEWS

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

α-Halogenoacetanilides as Hydrogen-Bonding Organocatalysts that Activate Carbonyl Bonds: Fluorine versus Chlorine and Bromine

(2014) Sylvain Koeller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Successful fluorine-containing herbicide agrochemicals

(2014) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Polarity Reversal Catalysis in Radical Reductions of Halides by N-Heterocyclic Carbene Boranes

(2012) Xiangcheng Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Resin glycosides from the aerial parts of Operculina turpethum

(2012) Wenbing Ding et al.   PHYTOCHEMISTRY

Organic fluorine compounds: a great opportunity for enhanced materials properties

(2011) Ricarda Berger et al.   CHEMICAL SOCIETY REVIEWS

Multiwfn: A multifunctional wavefunction analyzer

(2011) Tian Lu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Selective α-defluorination of polyfluorinated esters and amides using SmI2/Et3N/H2O

(2010) Jenny Wettergren et al.   CHEMICAL COMMUNICATIONS

New Boryl Radicals Derived from N-Heteroaryl Boranes: Generation and Reactivity

(2010) Jacques Lalevée et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation of NHC Borane Complexes by Lewis Base Exchange with Amine− and Phosphine−Boranes

(2010) Malika Makhlouf Brahmi et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Fluoroazaindolines by an Uncommon RadicalipsoSubstitution of a Carbon−Fluorine Bond

(2010) Yann Laot et al.   ORGANIC LETTERS

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of Lewis base coordination on boryl radical reactivity: investigation using laser flash photolysis and kinetic ESR

(2009) Jacques Lalevée et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

N-Heterocyclic Carbene Boryl Radicals: A New Class of Boron-Centered Radical

(2009) Shau-Hua Ueng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Density Functionals with Broad Applicability in Chemistry

(2008) Yan Zhao et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Complexes of Borane and N-Heterocyclic Carbenes: A New Class of Radical Hydrogen Atom Donor

(2008) Shau-Hua Ueng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Long-range corrected hybrid density functionals with damped atom–atom dispersion corrections

(2008) Jeng-Da Chai et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS