Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds

Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

(2018) Wenjun Miao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

(2017) Jing-jing Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

Preparation of Quaternary Centers via Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling of Tertiary Sulfones

(2017) Zachary T. Ariki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe-Catalyzed C–C Bond Construction from Olefins via Radicals

(2017) Julian C. Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C–N Bond Activation

(2017) Corey H. Basch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative alkenylation

(2017) Jacob T. Edwards et al.   NATURE

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides

(2017) Jie Sheng et al.   ORGANIC LETTERS

Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Processes

(2017) Gregory C. Fu   ACS Central Science

Nickel-Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1-Bromo-1,1-difluoroalkanes

(2016) Yu-Lan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms

(2016) Tian Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids

(2016) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel- and Photoredox-Catalyzed Cross-Coupling Reactions of Aryl Halides with 4-Alkyl-1,4-dihydropyridines as Formal Nucleophilic Alkylation Reagents

(2016) Kazunari Nakajima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt/diamine-catalyzed 1,1-difluoroethylation and 2,2,2-trifluoroethylation of aryl Grignard reagents with corresponding fluoroalkyl halides

(2016) Yuhki Ohtsuka et al.   JOURNAL OF FLUORINE CHEMISTRY

Expanding the Potential of Heteroaryl Vinyl Sulfones

(2016) Eduardo Rodrigo et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Active Esters in Fe-Catalyzed C–C Coupling

(2016) Fumihiko Toriyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

(2016) Josep Cornella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling

(2016) Samantha A. Green et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radicals: Reactive Intermediates with Translational Potential

(2016) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Pd-Catalyzed Transfer of Difluorocarbene

(2016) Xiao-Yun Deng et al.   ORGANIC LETTERS

Modified Julia Olefination on Anhydrides: Extension and Limitations. Application to the Synthesis of Maculalactone B

(2016) Nicolas Dussart et al.   ORGANIC LETTERS

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Copper-Catalyzed Boron-Selective C(sp2)–C(sp3) Oxidative Cross-Coupling of Arylboronic Acids and Alkyltrifluoroborates Involving a Single-Electron Transmetalation Process

(2016) Siyi Ding et al.   ACS Catalysis

Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide

(2015) Lun An et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Monofluoromethylation of Aryl Boronic Acids

(2015) Yi-Ming Su et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Base-Free Photoredox/Nickel Dual-Catalytic Cross-Coupling of Ammonium Alkylsilicates

(2015) Matthieu Jouffroy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide

(2015) Jingyu Hu et al.   ORGANIC LETTERS

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

(2015) Zhang Feng et al.   ORGANIC LETTERS

A straightforward synthesis of alkyl 1H-tetrazol-5-yl thioethers via a one-pot reaction of aldehydes and 1H-tetrazole-5-thiols mediated by N-tosylhydrazones

(2015) Le-Le Li et al.   RSC Advances

Simple Access to Elusive α-Boryl Carbanions and Their Alkylation: An Umpolung Construction for Organic Synthesis

(2014) Kai Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Negishi Arylations of Propargylic Bromides: A Mechanistic Investigation

(2014) Nathan D. Schley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized olefin cross-coupling to construct carbon–carbon bonds

(2014) Julian C. Lo et al.   NATURE

Recent advances in homogeneous nickel catalysis

(2014) Sarah Z. Tasker et al.   NATURE

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

(2014) Christian Matheis et al.   ORGANIC LETTERS

Bimetallic Oxidative Addition in Nickel-Catalyzed Alkyl–Aryl Kumada Coupling Reactions

(2014) Jan Breitenfeld et al.   ORGANOMETALLICS

Single-electron transmetalation in organoboron cross-coupling by photoredox/nickel dual catalysis

(2014) J. C. Tellis et al.   SCIENCE

Merging photoredox with nickel catalysis: Coupling of  -carboxyl sp3-carbons with aryl halides

(2014) Z. Zuo et al.   SCIENCE

Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides

(2014) Yang Gu et al.   Nature Communications

Alternaric acid: formal synthesis and related studies

(2013) Michael C Slade et al.   Beilstein Journal of Organic Chemistry

Iron-Catalyzed Cross-Coupling of Unactivated Secondary Alkyl Thio Ethers and Sulfones with Aryl Grignard Reagents

(2013) Scott E. Denmark et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanism and Selectivity in Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Halides with Alkyl Halides

(2013) Soumik Biswas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)sulfonyl Group

(2013) Yanchuan Zhao et al.   ACS Catalysis

Nickel-Catalyzed Kumada Reaction of Tosylalkanes with Grignard Reagents to Produce Alkenes and Modified Arylketones

(2012) Ji-Cheng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

(2012) G. K. Surya Prakash et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides

(2012) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group

(2012) Yanchuan Zhao et al.   ORGANIC LETTERS

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

(2011) Kenichi Fujikawa et al.   ORGANIC LETTERS

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS

1-tert-Butyl-1H-tetrazol-5-yl fluoromethyl sulfone (TBTSO2CH2F): a versatile fluoromethylidene synthon and its use in the synthesis of monofluorinated alkenes via Julia–Kocienski olefination

(2010) Lingui Zhu et al.   TETRAHEDRON

Iron-Catalyzed Oxidative Heterocoupling Between Aliphatic and Aromatic Organozinc Reagents: A Novel Pathway for Functionalized Aryl-Alkyl Cross-Coupling Reactions

(2009) Gérard Cahiez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

(2009) Daqing Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorinated 1-Phenyl-1H-tetrazol-5-yl Sulfone Derivatives as General Reagents for Fluoroalkylidene Synthesis

(2009) Arun K. Ghosh et al.   JOURNAL OF ORGANIC CHEMISTRY

Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl

(2008) Fabian M. Piller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION