Review
Biodiversity Conservation
Kevin R. Wilcox, Anping Chen, Meghan L. Avolio, Ethan E. Butler, Scott Collins, Rosie Fisher, Trevor Keenan, Nancy Y. Kiang, Alan K. Knapp, Sally E. Koerner, Lara Kueppers, Guopeng Liang, Eva Lieungh, Michael Loik, Yiqi Luo, Ben Poulter, Peter Reich, Katherine Renwick, Melinda D. Smith, Anthony Walker, Ensheng Weng, Kimberly J. Komatsu
Summary: This article discusses the shortcomings of herbaceous plant community representation in predictive models, pointing out that the model representation of grassland and herbaceous ecosystems lags behind tree communities and forests. The article identifies two important knowledge gaps: incomplete understanding of the principles governing herbaceous vegetation dynamics and limitations in the current model structure and parameterization of grass and other herbaceous plant functional types. The article provides directions for improving the representation of herbaceous communities within models through empirical research and model improvements.
GLOBAL CHANGE BIOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Anthony J. Hannan
Summary: The study found a link between tandem repeats in DNA and autism spectrum disorder, which could provide insights into other human disorders. Bioinformatic analysis was used to study tandem repeat mutations in autism.
Review
Biology
Aaron W. Jurrjens, Marcus M. Seldin, Corey Giles, Peter J. Meikle, Brian G. Drew, Anna C. Calkin
Summary: Cardiometabolic diseases result from genetic, environmental, and lifestyle factors and identifying those at high risk is challenging. Systems genetics, using population-based approaches, can elucidate the genetic and environmental causes of these diseases. Mouse genetic reference panels provide a complementary approach to human genome-wide association studies, allowing for controlled investigation of genetic and phenotypic variation. Integrating multi-omics data from human and mouse populations can advance our understanding of cardiometabolic diseases.
Review
Psychology, Clinical
Laura Domenech, Carolina Cappi, Matt Halvorsen
Summary: Tourette syndrome is a severe neuropsychiatric disorder with a prevalence of 1% in children, and genetic factors play an important role in the overall risk architecture.
PSYCHOLOGICAL MEDICINE
(2021)
Editorial Material
Oncology
Joseph Lachance
Summary: Emami and colleagues analyzed genetic data from over 200,000 European men to identify rare alleles associated with prostate cancer. Their study not only described statistical associations between genetic variants and cancer risk, but also demonstrated the clinical utility of genetic predictors of disease risk, bridging the gap between genome-wide association studies and biological mechanisms underlying prostate cancer risk.
Review
Clinical Neurology
Nadia Dehghani, Jose Bras, Rita Guerreiro
Summary: The majority of genome-wide association studies are conducted using samples from European genetic backgrounds, but there is a need to increase diversity in populations studied. Researching currently understudied populations for Alzheimer's disease genetics can provide valuable insights and contribute to a better understanding of the genetic architecture of the disease in different populations. Despite challenges in assimilating large sample sizes and detecting rare variants, studying understudied populations has shed light on novel genetic factors associated with Alzheimer's disease.
Editorial Material
Multidisciplinary Sciences
Ali H. Brivanlou, Nicolas Rivron, Norbert Gleicher
Summary: In the next few years, continued exploration of human embryology is expected to bring significant advances in regenerative and reproductive medicine. As technologies progress, it is important to not only focus on their potential clinical applications, but also to consider the ethical implications involved.
NATURE COMMUNICATIONS
(2021)
Article
Biodiversity Conservation
Aldo Compagnoni, Sanne Evers, Tiffany Knight
Summary: This study advocates for new research approaches to estimating the effects of climate on plant populations by sampling replicate populations in locations with similar climates. It first analyzes spatial locations in the conterminous USA to determine the distance at which spatial replicates should be to minimize temporal correlations in climate. The study then uses simulations to demonstrate the potential benefits of spatial replication in expanding the range of climates sampled. The results highlight the untapped opportunity of spatial replication to study the effects of climate on demography and fill knowledge gaps in population ecology.
Review
Engineering, Environmental
Junwei Liu, Yunfei Zhang, Shuai Li, Cristian Valenzuela, Shukuan Shi, Chongxu Jiang, Shiqiang Wu, Long Ye, Ling Wang, Zhihua Zhou
Summary: With the increasing concern over global warming and climate change, there is a growing demand for clean cooling technologies. Radiative sky cooling (RSC) has emerged as a promising solution that can dissipate heat without causing pollution or consuming energy. However, the low cooling power has hindered its large-scale application. This article provides a critical review of recent efforts to address this challenge and offers potential avenues for further advancements in RSC technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Clinical Neurology
Macarena Cabrera-Serrano, Gianina Ravenscroft
Summary: This review summarizes recent advances in the genetics of rhabdomyolysis, including the identification of environmental triggers and gene defects that can cause the condition. It also highlights the role of muscular dystrophy and myopathy genes in triggering rhabdomyolysis, as well as the discovery of novel gene variants associated with the disease. Additionally, the review emphasizes the importance of accurate genetic diagnosis for optimal clinical management and genetic counseling.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Business
Nicholas Burton, Mai Chi Vu, Allan Discua Cruz
Summary: By studying 12 Buddhist family businesses in Vietnam, this study reveals the connection between non-kin succession and Buddhist philosophy, particularly the principles of non-attachment and impermanence. It shows that these principles influence how entrepreneurs reject succession as a biological and material legacy, and instead view it as the continuation of a social legacy.
JOURNAL OF BUSINESS RESEARCH
(2022)
Editorial Material
Ecology
Francisco Sylvester, Fabian G. Weichert, Veronica L. Lozano, Ksenia J. Groh, Miklos Balint, Lisa Baumann, Claus Baessler, Werner Brack, Barbara Brandl, Joachim Curtius, Paul Dierkes, Petra Doell, Ingo Ebersberger, Sotirios Fragkostefanakis, Eric J. N. Helfrich, Thomas Hickler, Sarah Johann, Jonas Jourdan, Sven Klimpel, Helge Kminek, Florencia Liquin, Darrel Moellendorf, Thomas Mueller, Joerg Oehlmann, Richard Ottermanns, Steffen U. Pauls, Meike Piepenbring, Jakob Pfefferle, Gerrit Jasper Schenk, J. F. Scheepens, Martin Scheringer, Sabrina Schiwy, Antje Schlottmann, Flurina Schneider, Lisa M. Schulte, Maria Schulze-Sylvester, Ernst Stelzer, Frederic Strobl, Andrea Sundermann, Klement Tockner, Tobias Troeger, Andreas Vilcinskas, Carolin Voelker, Ricarda Winkelmann, Henner Hollert
Summary: Chemical pollution research needs to be integrated with other factors contributing to biodiversity loss and the assessment of human impacts on ecosystems in order to provide more effective guidance for biodiversity loss mitigation.
NATURE ECOLOGY & EVOLUTION
(2023)
Review
Biochemistry & Molecular Biology
Timothy J. Hark, Jeffrey N. Savas
Summary: Stable isotope labeling with mass spectrometry is a powerful strategy for assessing protein levels, turnover, and localization. Applying these methods to neurodegenerative disorders can uncover new aspects of disease etiology. Recent research has shown that stable isotopes-MS can be used to investigate early pathological mechanisms of Alzheimer's disease using mouse models.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Cell Biology
Erwann Pain, Sonia Shinhmar, Robin S. B. Williams
Summary: Ketogenic diets, including the medium chain triglyceride ketogenic diet, have been used for many years to improve health and as a dietary treatment for various diseases. Recent studies using Dictyostelium discoideum as a model have controversially proposed direct molecular mechanisms for decanoic acid, the main component of this diet, independent of ketone generation. These findings could potentially impact the treatment of disorders such as epilepsy, cancer, and bipolar disorder.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Ophthalmology
Gernot Schliessleder, Angelos Kalitzeos, Melissa Kasilian, Navjit Singh, Ziyuan Wang, Zhihong Hu, Manuel Grosspoetzl, SriniVas Sadda, Andreas Wedrich, Michel Michaelides, Rupert W. Strauss
Summary: This study aimed to investigate the retinal structure in patients with autosomal-dominant and autosomal-recessive PROM1-associated retinal degeneration. Ophthalmic examination and multimodal retinal imaging revealed atrophic lesions, thinning of the outer retinal layers, and variations in cone photoreceptor quantification, which were related to disease-causing variants and age.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Psychiatry
Travis T. Mallard, Jeanne E. Savage, Emma C. Johnson, Yuye Huang, Alexis C. Edwards, Jouke J. Hottenga, Andrew D. Grotzinger, Daniel E. Gustavson, Mariela Jennings, Andrey Anokhin, Danielle M. Dick, Howard J. Edenberg, John R. Kramer, Dongbing Lai, Jacquelyn L. Meyers, Ashwini K. Pandey, Kathryn Paige Harden, Michel G. Nivard, Eco J. C. de Geus, Dorret Boomsma, Arpana Agrawal, Lea K. Davis, Toni-Kim Clarke, Abraham A. Palmer, Sandra Sanchez-Roige
Summary: This study utilized genomic structural equation modeling to explore the genetics of alcohol consumption and problematic consequences as measured by the Alcohol Use Disorders Identification Test (AUDIT). Through a large-scale GWAS and multivariate approach, the authors identified genetic correlations among the AUDIT items and constructed an aggregate measure strongly associated with alcohol dependence.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
E. E. Levitt, A. Oshri, M. Amlung, L. A. Ray, S. Sanchez-Roige, A. A. Palmer, J. MacKillop
Summary: This study examines the relationship between delay discounting and multiple psychiatric conditions and finds significant associations between delay discounting and several disorders. The findings provide support for delay discounting as a transdiagnostic indicator and suggest further research is warranted.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Laura Vilar-Ribo, Judit Cabana-Dominguez, Lourdes Martorell, Josep Antoni Ramos-Quiroga, Sandra Sanchez-Roige, Abraham A. Palmer, Elisabet Vilella, Marta Ribases, Gerard Muntane, Maria Soler Artigas
Summary: There is evidence linking ADHD to reduced life expectancy. Individuals with ADHD have a higher mortality rate, which may be caused by unhealthy lifestyle behaviors, social adversity, and mental health problems. The study found a negative genetic correlation between ADHD and parental lifespan, indicating a common genetic background. These findings highlight the importance of ADHD as a health condition that can negatively affect lifespan and future life outcomes.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sandra Sanchez-Roige, Mariela Jennings, Hayley H. A. Thorpe, Jazlene Mallari, Lieke C. van der Werf, Sevim B. Bianchi, Yuye Huang, Calvin Lee, Travis T. Mallard, Samuel A. Barnes, Jin Yi Wu, Amanda M. Barkley-Levenson, Ely C. Boussaty, Cedric E. Snethlage, Danielle Schafer, Zeljana Babic, Boyer D. Winters, Katherine E. Watters, Thomas Biederer, Stella Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, Emily Bullis, Daniella Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, Teresa Filshtein, Kipper Fletez-Brant, Will Freyman, Karl Heilbron, Pooja M. Gandhi, Karl Heilbron, Barry Hicks, David A. Hinds, Ethan M. Jewett, Yunxuan Jiang, Katelyn Kukar, Keng-Han Lin, Maya Lowe, Jey C. McCreight, Matthew H. McIntyre, Steven J. Micheletti, Meghan E. Moreno, Joanna L. Mountain, Priyanka Nandakumar, Elizabeth S. Noblin, Jared O'Connell, Aaron A. Petrakovitz, G. David Poznik, Morgan Schumacher, Anjali J. Shastri, Janie F. Shelton, Jingchunzi Shi, Suyash Shringarpure, Vinh Tran, Joyce Y. Tung, Xin Wang, Wei Wang, Catherine H. Weldon, Peter Wilton, Alejandro Hernandez, Corinna Wong, Christophe Toukam Tchakoute, James Mackillop, David N. Stephens, Sarah L. Elson, Pierre Fontanillas, Jibran Y. Khokhar, Jared W. Young, Abraham A. Palmer
Summary: Impulsivity is a heritable trait associated with various forms of psychopathology, and the gene CADM2 is found to be implicated in it. Genome-wide association studies and mouse experiments have confirmed this finding. This study further explores the role of CADM2 in impulsivity and its link with other psychiatric and somatic traits.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Holly E. Poore, Alexander Hatoum, Travis T. Mallard, Sandra Sanchez-Roige, Irwin D. Waldman, Abraham A. Palmer, K. Paige Harden, Peter B. Barr, Danielle M. Dick
Summary: This study used genomic structural equation modeling to investigate the shared genetic architecture between externalizing phenotypes and substance use disorders (SUDs). The results showed high genetic correlations between externalizing and addiction risk factors, but also revealed some differences. These findings can contribute to the identification of specific genetic influences on externalizing and SUDs in future research.
Article
Behavioral Sciences
Camille M. Williams, Holly Poore, Peter T. Tanksley, Hyeokmoon Kweon, Natasia S. Courchesne-Krak, Diego Londono-Correa, Travis T. Mallard, Peter Barr, Philipp D. Koellinger, Irwin D. Waldman, Sandra Sanchez-Roige, K. Paige Harden, Abraham A. Palmer, Danielle M. Dick, Richard Karlsson Linner
Summary: In this study, a systematic approach to assess the comparability of GWAS summary statistics that include versus exclude restricted data was proposed, using multivariate GWAS as an example. The results showed that although down-sampling resulted in a loss of genetic signal and fewer genome-wide significant loci, measures such as model fit, gene-property analyses, genetic correlations, and polygenic score analyses remained robust.
Article
Biochemistry & Molecular Biology
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsing Balamkundu, Charles Vidoudez, Michael S. Demott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
Summary: DNA damage is a major cause of genomic instability in various diseases. Traditional analytical methods provide limited insight into the spectrum of DNA lesions in living organisms. In this study, untargeted chromatography-coupled tandem mass spectrometry (LC-MS/MS) was used to explore the landscape of DNA modifications in rat and human tissues. A total of 114 potential DNA adducts were identified in heart, liver, brain, and kidney tissues of rats, and 111 in human heart and brain tissues using the LC-MS/MS approach. Subsequent targeted analysis revealed species, tissue, age, and sex biases in the DNA adducts. This study demonstrates the potential of adductomics in discovering disease-driving DNA adducts and provides a valuable resource for characterizing new forms of DNA damage and developing biomarkers for aging and disease.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Psychology, Clinical
Daniel E. Gustavson, Claire L. Morrison, Travis T. Mallard, Mariela V. Jennings, Pierre Fontanillas, Sarah L. Elson, Abraham A. Palmer, Naomi P. Friedman, Sandra Sanchez-Roige
Summary: Individual differences in self-control predict many health and life outcomes. Genetic influences on executive function and impulsivity were found to independently predict variance in mental health and other outcomes. This suggests that executive function and impulsivity are genetically separable and show independent associations with mental health.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
History
Sergio Bravo Sanchez
Summary: The absence of Emperor Charles V in Castile from 1528 onwards led to the rise of his wife Isabel of Portugal as the head of the government, creating opportunities for the high aristocracy to challenge royal authority. The matrimonial dispute between the IV Count of Uruena and the ladies Maria Enriquez and Maria de la Cueva, lasting for almost five years, resulted in a confrontation between lineages with significant political implications.
TIEMPOS MODERNOS-REVISTA ELECTRONICA DE HISTORIA MODERNA
(2023)
Meeting Abstract
Clinical Neurology
M. Rose, T. Ray, N. Shirooni, A. Tenney, D. Creighton, A. Gelber, E. Abdollahzadeh, A. Barroga, K. Chen, H. Guardiano, J. Li, L. Nguyen, V. Nguyen, J. Padilla-Trigo, B. Pham, Y. Trinh, X. Yang, M. Tischfield, E. Murray, T. Collins, A. Nugent, P. Ang, S. Izen, M. Bauer, W. Huang, R. Satija, O. Rozenblatt-Rosen, E. Macosko, F. Chen, A. Regev, E. Engle
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Meeting Abstract
Neurosciences
Sandra Sanchez-Roige, Mariela Jennings, Hayley Thorpe, Jazlene Mallari, Lieke van der Werf, Sevim Bianchi, Calvin Lee, Travis Mallard, Samuel Barnes, Jin Yi Wu, Amanda Barkley-Levenson, Ely Boussaty, Cedric Snethlage, Danielle Schafer, Zeljana Babic, Boyer W. Winters, Katherine Watters, Thomas Biederer, James MacKillop, David Stephens, Sarah L. Elson, Pierre Fontanillas, Jibran Khokhar, Jared Young, Abraham Palmer
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Sandra Sanchez-Roige, Mariela Jennings, Sylvanus Toikumo, Hyunjoon Lee, Travis Mallard, Sevim Bianchi, Benjamin Pham, Natasia Courchesne-Krak, Maria Niarchou, Million Veteran Program, Dana Hancock, Ke Xu, Jordan Smoller, Lea Davis, Amy Justice, Hank Kranzler, Rachel Kember
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Behavioral Sciences
Daniel E. Gustavson, Claire L. Morrison, Travis T. Mallard, Pierre Fontanillas, Sarah L. Elson, Naomi P. Friedman, Abraham A. Palmer, Sandra Sanchez-Roige
Meeting Abstract
Behavioral Sciences
Holly E. Poore, Peter B. Barr, Alexander S. Hatoum, Travis T. Mallard, Sandra Sanchez-Roige, Irwin D. Waldman, Abraham A. Palmer, K. Paige. Harden, Philipp D. Koellinger, Danielle M. Dick