Article
Biochemistry & Molecular Biology
Giovanna Azzarito, Michele Visentin, Brigitte Leeners, Raghvendra K. Dubey
Summary: Vascular and lymphatic vessels play a crucial role in breast cancer growth and metastasis. The study found that the secretome of estrogen receptor-positive breast cancer cells can stimulate vascular angiogenesis and inhibit lymphatic growth, which has significant pathological and physiological implications for breast cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Bin Wang, Hanfei Guo, Hongquan Yu, Yong Chen, Haiyang Xu, Gang Zhao
Summary: EGR1, a transcription factor, plays a role in tissue injury, immune responses, and fibrosis. Recent studies suggest EGR1's involvement in cancer initiation and progression, potentially affecting tumor cell proliferation, invasion, metastasis, and angiogenesis. The specific mechanisms by which EGR1 modulates these processes are still under investigation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Biotechnology & Applied Microbiology
Weiwei Wang, Jianjun Wu, Xulei Dai, Kun Cheng
Summary: This study demonstrates that CCL23 is expressed at low levels in hepatocellular carcinoma (HCC) and can inhibit the proliferation, invasion, and angiogenesis of HCC cells in vitro, an action that is negatively associated with and can be blocked by TFAP4.
Article
Oncology
Tong Liu, Peilong Li, Juan Li, Qiuchen Qi, Zhaowei Sun, Shuang Shi, Yan Xie, Shibiao Liu, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Cancer-cell-released exosomal miRNAs play a significant role in tumor microenvironment communication, with miR-320b identified as closely associated with lymphangiogenesis and lymphatic metastasis in ESCC patients. Through transfer by exosomes, miR-320b activates the AKT pathway in HLECs independently of VEGF-C, affecting tube formation, migration, and EMT progression in ESCC cells. Furthermore, METTL3 positively regulates pri-miR-320b maturation through an m6A-dependent mechanism.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Oncology
Wanzhen Xu, Manfeng Wang, Yang Bai, Yong Chen, Xiaoshan Ma, Zhiqing Yang, Liyan Zhao, Yunqian Li
Summary: This article reviews the possible mechanism of MFAP2 in tumorigenesis and progression, providing a reference for clinical prognosis and the discovery of new therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Chang Liu, Li-Qian Xuan, Kai Li, Zhuo Feng, Chan Lv, Xing-Jia Li, Xiao-Dan Ji, Rong Wan, Jie Shen
Summary: The study found that Shikonin can inhibit proliferation and invasion of QBC939 cells and induce apoptosis; these biological behaviors mainly occurred through upregulating the expression of caspase-3 and caspase-8, and downregulating the expression of MMP-9 and EGFR.
CELL TRANSPLANTATION
(2021)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Young Kim, Hyun Hwangbo, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Hyesook Lee, Gi-Young Kim, Sung-Kwon Moon, Sun-Hee Leem, Seok Joong Yun, Wun-Jae Kim, JaeHun Cheong, Cheol Park, Yung Hyun Choi
Summary: The study demonstrates that betulinic acid induces apoptosis, necrosis, and cell cycle arrest in bladder cancer cells through modulation of cell cycle regulators and mitochondrial function, leading to decreased proliferation and migration.
Review
Chemistry, Medicinal
Zhun Cai, Chenyang Mao, Yeqing Wang, Zheyi Zhu, Sisi Xu, Dongqing Chen, Yufeng Chen, Wenjie Ruan, Binbo Fang
Summary: This review outlines the new expertise and research progress with luteolin as an antitumor agent, highlighting its various effects on tumor treatment. Although clinical studies have not yet been widely carried out, basic studies have confirmed the effectiveness of luteolin as an antineoplastic agent or anticancer adjuvant.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yixuan Yang, Bing Zhu, Zhaofeng Ning, Xiaodong Wang, Zhaoxia Li, Chunxia Zhang, Linchun Wen
Summary: This study reveals the promoting effect of circ_0058063 on ESCC by regulating miR-4319 and increasing THBS1 expression. It provides a potential direction for targeted therapy in ESCC treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Niu, Keyuan Zhao, Yuanyuan Zheng, Yapeng Wang, Ruoyang Liu, Yiming Zhang, Lihui Wang, Yongjun Wu, Xuefeng Bai, Baoping Qiao
Summary: Emerging evidences indicate that ANXA13 is upregulated in ccRCC and promotes cell proliferation, migration, invasion, and apoptosis. Thus, ANXA13 may serve as a potential biomarker and therapeutic target in ccRCC.
Article
Cell Biology
Ruijie Zhang, Chunxiao Liu, Liu Yang, Tong Ji, Nana Zhang, Xiaoqing Dong, Xin Chen, Jing Ma, Wei Gao, Shile Huang, Long Chen
Summary: Research shows that PD toxins induce neuronal apoptosis by generating H2O2 through NOX2, hindering the AMPK/Akt-mTOR signaling pathway. Inhibiting NOX2 or using antioxidants may help alleviate neuronal loss caused by oxidative stress.
CELLULAR SIGNALLING
(2022)
Article
Integrative & Complementary Medicine
Yu Gan, Shi-Le Huang, Meng-Qi Luo, Min Chen, Hui Zheng
Summary: The efficacy of acupuncture combined with usual care in treating irritable bowel syndrome (IBS) has been studied through network meta-analysis. The results show that manual acupuncture combined with usual care is the most effective approach, and adding manual acupuncture to usual care provides additional benefits.
ACUPUNCTURE IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Di Qin, Qing-Feng Tao, Shi-Le Huang, Min Chen, Hui Zheng
Summary: This study compared the efficacy of eluxadoline and antispasmodics in the treatment of irritable bowel syndrome (IBS). The results showed that eluxadoline was as effective as antispasmodics in relieving abdominal pain, but had more reported adverse events. Therefore, antispasmodics remain the first choice for the treatment of IBS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qinghui Lan, Peiqing Guan, Chunzheng Huang, Shile Huang, Peiling Zhou, Changzheng Zhang
Summary: This study demonstrated that arecoline significantly increased the firing rate of dopaminergic neurons and induced burst firing. This may contribute to areca nut dependency and provide a potential target for cessation therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Madison Wynne El-Saadi, Xinli Tian, Mychal Grames, Michael Ren, Kelsea Keys, Hanna Li, Erika Knott, Hong Yin, Shile Huang, Xiao-Hong Lu
Summary: In this study, we developed an in vivo tool called PRISM to sensitively probe brain genotoxic stress and found that genotoxic stress is a significant etiological factor in Parkinson's disease and other neurodegenerative disorders.
Article
Pharmacology & Pharmacy
Yajie Yao, Jiawei Zhu, Shanshan Qin, Zhihan Zhou, Qingyu Zeng, Ruyu Long, Zun Mao, Xiaoqing Dong, Rui Zhao, Ruijie Zhang, Shuangquan Zhang, Shile Huang, Long Chen
Summary: Resveratrol induces autophagy to inhibit BAFF-stimulated B-cell proliferation and survival, suggesting its potential for the prevention and treatment of autoimmune diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane-Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu
Summary: Fisetin has potential therapeutic effects on refractory psoriasis by inhibiting abnormal immune response, promoting keratinocyte differentiation and autophagy, and reducing disease inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Neurosciences
Qianyun Yu, Ruijie Zhang, Tianjing Li, Liu Yang, Zhihan Zhou, Long Hou, Wen Wu, Rui Zhao, Xiaoling Chen, Yajie Yao, Shile Huang, Long Chen
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Qianyun Yu, Ruijie Zhang, Tianjing Li, Liu Yang, Zhihan Zhou, Long Hou, Wen Wu, Rui Zhao, Xiaoling Chen, Yajie Yao, Shile Huang, Long Chen
Summary: Defective autophagy is involved in the development of Parkinson's disease (PD), and PD toxins impede autophagy through the PTEN/Akt signaling pathway, leading to neuronal apoptosis. Activation of PTEN and inactivation of Akt by PD toxins inhibit autophagy, and this process is regulated by the protein Parkin. Manipulation of PTEN/Akt/autophagy signaling with antioxidants could be a potential therapeutic strategy for preventing neuronal loss in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Terry C. Lairmore, Jehan Abdulsattar, Arrigo De Benedetti, Runhua Shi, Shile Huang, Md Imtiaz Khalil, Stephan N. Witt
Summary: Immunohistochemical analysis showed an inverse association between menin expression and tumor grade in cholangiocarcinoma. Menin expression was higher in low-grade tumors and lower in high-grade tumors. Menin expression was also positively associated with fibrosis status.
BMC RESEARCH NOTES
(2023)
Article
Biochemistry & Molecular Biology
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Guie Chen, Yanqin Lai, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Summary: Rabies is a highly fatal zoonotic disease with no effective treatment available. Recent studies have shown that the tripartite-motif protein (TRIM) family plays a role in regulating viral replication. Specifically, tripartite-motif protein 21 (TRIM21) has been found to be upregulated in the brain tissue of mice infected with rabies virus and its knockdown inhibits viral replication. Knockdown of interferon-alpha and interferon-beta further modulates the inhibition of viral replication caused by TRIM21 knockdown. TRIM21 regulates RABV replication via the IRF7-IFN axis, highlighting its potential as a target for rabies treatment or management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Genetics & Heredity
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Summary: TRIM25 plays a crucial role in the infection of rabies virus, regulating its replication through the RIG-I-IFN axis. This finding suggests that TRIM25 may serve as a potential target for the development of antiviral drugs against rabies.
Meeting Abstract
Oncology
Lin Li, Lie Liu, Shile Huang
Meeting Abstract
Oncology
Shile Huang, Lei Liu, Yan Luo
