Genetic architecture of schizophrenia: a review of major advancements

Functional connectome-wide associations of schizophrenia polygenic risk

(2020) Hengyi Cao et al.   MOLECULAR PSYCHIATRY

Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations

(2020) Daniel P. Howrigan et al.   NATURE NEUROSCIENCE

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia

(2020) Elliott Rees et al.   NATURE NEUROSCIENCE

Genetics of schizophrenia in the South African Xhosa

(2020) S. Gulsuner et al.   SCIENCE

Translating insights from neuropsychiatric genetics and genomics for precision psychiatry

(2020) Elliott Rees et al.   Genome Medicine

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

(2019) Patrick F. Sullivan et al.   CELL

Clinical indicators of treatment-resistant psychosis

(2019) Sophie E. Legge et al.   BRITISH JOURNAL OF PSYCHIATRY

A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation

(2019) Damon Polioudakis et al.   NEURON

Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study

(2019) Sathish Periyasamy et al.   JAMA Psychiatry

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems

(2019) Amanda B. Zheutlin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Non-Genetic Factors in Schizophrenia

(2019) Simona A. Stilo et al.   Current Psychiatry Reports

Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophrenia

(2019) Peter N. Fiorica et al.   PeerJ

A Transcriptome-Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

(2019) Lynsey S Hall et al.   HUMAN MOLECULAR GENETICS

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

(2019) Tim B. Bigdeli et al.   MOLECULAR PSYCHIATRY

Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish National Register and Genomic Study

(2019) Kaarina Kowalec et al.   MOLECULAR PSYCHIATRY

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

(2019) Charlotte A. Dennison et al.   SCHIZOPHRENIA RESEARCH

Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders

(2019) Katherine G. Jonas et al.   Translational Psychiatry

Distinct Polygenic Score Profiles in Schizophrenia Subgroups With Different Trajectories of Cognitive Development

(2019) Dwight Dickinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mortality in schizophrenia: 30-year nationwide follow-up study

(2018) A. Tanskanen et al.   ACTA PSYCHIATRICA SCANDINAVICA

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

(2018) Douglas M. Ruderfer et al.   CELL

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

(2018) Alexander Gusev et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016

(2018) Fiona J Charlson et al.   SCHIZOPHRENIA BULLETIN

Analysis of shared heritability in common disorders of the brain

(2018) et al.   SCIENCE

Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder

(2018) Judith Allardyce et al.   JAMA Psychiatry

Relatedness disequilibrium regression estimates heritability without environmental bias

(2018) Alexander I. Young et al.   NATURE GENETICS

Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia

(2018) David Curtis   PSYCHIATRIC GENETICS

Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia

(2018) Sarah E. Bergen et al.   AMERICAN JOURNAL OF PSYCHIATRY

Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis

(2018) Jian-Ping Zhang et al.   AMERICAN JOURNAL OF PSYCHIATRY

Polygenic risk for schizophrenia and associated brain structural changes: A systematic review

(2018) C. van der Merwe et al.   COMPREHENSIVE PSYCHIATRY

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Mortality and the relationship of somatic comorbidities to mortality in schizophrenia. A nationwide matched-cohort study

(2017) I. Bitter et al.   EUROPEAN PSYCHIATRY

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability

(2017) Tarjinder Singh et al.   NATURE GENETICS

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

(2017) Zhiqiang Li et al.   NATURE GENETICS

Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia

(2017) Theresa Wimberley et al.   SCHIZOPHRENIA BULLETIN

Negative symptoms: History of the concept and their position in diagnosis of schizophrenia

(2017) Sonia Dollfus et al.   SCHIZOPHRENIA RESEARCH

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

(2016) Christian R Marshall et al.   NATURE GENETICS

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

(2016) Tarjinder Singh et al.   NATURE NEUROSCIENCE

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia

(2016) Giulio Genovese et al.   NATURE NEUROSCIENCE

Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families

(2016) I-Jun Chou et al.   SCHIZOPHRENIA BULLETIN

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Erratum: Common alleles contribute to schizophrenia in CNV carriers

(2015) K E Tansey et al.   MOLECULAR PSYCHIATRY

High loading of polygenic risk in cases with chronic schizophrenia

(2015) S M Meier et al.   MOLECULAR PSYCHIATRY

Premature Mortality Among Adults With Schizophrenia in the United States

(2015) Mark Olfson et al.   JAMA Psychiatry

Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients

(2014) J Frank et al.   MOLECULAR PSYCHIATRY

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

(2014) Yun R Li et al.   Genome Medicine

The Penetrance of Copy Number Variations for Schizophrenia and Developmental Delay

(2013) George Kirov et al.   BIOLOGICAL PSYCHIATRY

Analysis of copy number variations at 15 schizophrenia-associated loci

(2013) Elliott Rees et al.   BRITISH JOURNAL OF PSYCHIATRY

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

(2013) D M Ruderfer et al.   MOLECULAR PSYCHIATRY

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Genome-Wide Association Study of Clinical Dimensions of Schizophrenia: Polygenic Effect on Disorganized Symptoms

(2012) Ayman H. Fanous et al.   AMERICAN JOURNAL OF PSYCHIATRY

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

A Systematic Review and Meta-Analysis of Recovery in Schizophrenia

(2012) E. Jaaskelainen et al.   SCHIZOPHRENIA BULLETIN

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2

(2011) Wei-Hua Yue et al.   NATURE GENETICS

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Penetrance for copy number variants associated with schizophrenia

(2010) E. Vassos et al.   HUMAN MOLECULAR GENETICS

A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants

(2010) F. Bourque et al.   PSYCHOLOGICAL MEDICINE

Common variants on chromosome 6p22.1 are associated with schizophrenia

(2009) Jianxin Shi et al.   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Common variants conferring risk of schizophrenia

(2009) Hreinn Stefansson et al.   NATURE

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

(2008) J. McGrath et al.   EPIDEMIOLOGIC REVIEWS

Psychiatric Comorbidities and Schizophrenia

(2008) P. F. Buckley et al.   SCHIZOPHRENIA BULLETIN