Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy

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Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells

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A prospective study of non-invasive preimplantation genetic testing for aneuploidies (NiPGT-A) using next-generation sequencing (NGS) on spent culture media (SCM)

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Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy

(2019) Lei Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extent of chromosomal mosaicism influences the clinical outcome of in vitro fertilization treatments

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Chromosomal mosaicism in human blastocysts: the ultimate challenge of preimplantation genetic testing?

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Should every embryo undergo preimplantation genetic testing for aneuploidy? A review of the modern approach to in vitro fertilization

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Status of preimplantation genetic testing and embryo selection

(2018) Santiago Munné   REPRODUCTIVE BIOMEDICINE ONLINE

Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions

(2018) Antonio Capalbo et al.   FERTILITY AND STERILITY

Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing

(2017) Santiago Munné et al.   FERTILITY AND STERILITY

Single-cell DNA methylome sequencing of human preimplantation embryos

(2017) Ping Zhu et al.   NATURE GENETICS

Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality

(2016) Shuoping Zhang et al.   FERTILITY AND STERILITY

Single center validation of routine blastocyst biopsy implementation

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(2016) Alessia Deglincerti et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization

(2016) Juanjuan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis

(2016) Danilo Cimadomo et al.   Biomed Research International

Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells†

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Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts

(2015) Ermanno Greco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preimplantation genetic diagnosis (PGD) influences adrenal development and response to cold stress in resulting mice

(2013) Yan Zeng et al.   CELL AND TISSUE RESEARCH

Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice

(2013) Yibo Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selecting the optimal time to perform biopsy for preimplantation genetic testing

(2013) Katherine L. Scott et al.   FERTILITY AND STERILITY

Influence of Activin A Supplementation During Human Embryonic Stem Cell Derivation on Germ Cell Differentiation Potential

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Developmental Stages in Human Embryos: Revised and New Measurements

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