Article
Biochemistry & Molecular Biology
Jing Gao, Li Ma, Jie Yin, Gang Liu, Jie Ma, SiTing Xia, SaiMing Gong, Qi Han, TieJun Li, YongZhong Chen, YuLong Yin
Summary: This study found that Camellia seed oil can improve dyslipidemia and lipid accumulation in mice fed a high-fat diet through the reorganization of gut microbiota. Camellia oil supplementation regulates the composition and functional profiling of gut microbiota, increases the abundance of beneficial bacteria, and reduces lipid levels in serum and liver. Furthermore, Camellia oil supplementation inhibits the mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu
Summary: Omega-3 PUFAs rich in fish oil are believed to prevent obesity by improving lipid metabolism and regulating gut microbiota. Microalgae oil, particularly Schizochytrium microalgae oil (SMO) with a high DHA proportion, is shown to have comparable weight-loss effects to commercial fish oil and a weight-loss drug. In addition, SMO has different effects on gut microbiota, increasing the abundance of beneficial bacteria and inhibiting obesity-promoting bacteria. SMO also helps restore the disturbed metabolic capability of gut microbiota caused by a high-fat diet.
Article
Agriculture, Dairy & Animal Science
Wenjuan Xun, Mengyao Ji, Zhonghua Ma, Tanjie Deng, Wen Yang, Guanyu Hou, Liguang Shi, Ting Cao
Summary: This study aimed to investigate the effects of dietary emodin (ED) on the intestinal mucosal barrier, NF-kB pathways, and gut microbial flora in LPS-induced piglets. The results showed that ED supplementation improved the intestinal mucosal barrier, reduced inflammation, and enhanced antioxidant capacity, as well as modulated the gut microbial composition. These findings suggest that ED can alleviate LPS-induced intestinal mucosal barrier injury by modulating gut microbiota.
Article
Nutrition & Dietetics
Liping Huang, Zhongyu Liu, Peng Wu, Xiaojing Yue, Zhuoshi Lian, Peishi He, Yarui Liu, Ruisi Zhou, Jie Zhao
Summary: Pre-eclampsia (PE) is a serious pregnancy complication, and this study found that Puerariae lobatae Radix (PLR) supplementation could alleviate PE symptoms in a mouse model. PLR improved hypertension, proteinuria, fetal and placental weights, and increased the levels of VEGF and PlGF. It also protected the placenta from oxidative stress and mitigated placental damage by activating a specific pathway. Additionally, PLR supplementation corrected gut dysbiosis and improved the abundance of beneficial bacteria in the intestines. These findings suggest that modulating the gut microbiota through PLR supplementation could be an effective strategy for the treatment of PE.
Article
Food Science & Technology
Fan Wan, Xueying Cai, Mengyu Wang, Liang Chen, Ruqing Zhong, Lei Liu, Bao Yi, Fujiang Hou, Hongfu Zhang
Summary: Chlorogenic acid supplementation can effectively ameliorate DSS-induced colitis by activating the Nrf-2/HO-1 pathway to suppress oxidative stress and inflammatory responses, and promoting gut barrier.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Jing Yan, Qiuyan Xue, Wenyi Chen, Kun Wang, Dong Peng, Jinjin Jiang, Pan Li, Bing Du
Summary: The probiotics-fermented rice buckwheat (FRB) significantly reduced weight gain and visceral obesity, improved dyslipidemia, alleviated oxidative stress and chronic inflammation in high-fat diet-induced mice. Furthermore, FRB intervention inhibited hepatic cholesterol synthesis, promoted lipolysis, and reversed gut dysbiosis induced by high-fat diet, demonstrating its beneficial effects on hyperlipidemia.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Roy Hajjar, Emmanuel Gonzalez, Gabriela Fragoso, Manon Oliero, Ahmed Amine Alaoui, Annie Calve, Herve Vennin Rendos, Souad Djediai, Thibault Cuisiniere, Patrick Laplante, Claire Gerkins, Ayodeji Samuel Ajayi, Khoudia Diop, Nassima Taleb, Sophie Therien, Fredericke Schampaert, Hefzi Alratrout, Francois Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric Debroux, Jean-Francois Cailhier, Bertrand Routy, Borhane Annabi, Nicholas J. B. Brereton, Carole Richard, Manuela M. Santos
Summary: This study assessed the role of gut microbiota in colonic surgical healing by performing fecal microbiota transplantation in mice. Certain bacterial strains were found to be associated with healing capacity and gut integrity, and the preoperative white blood cell count of patients was also correlated with postoperative colonic healing quality. These findings have important implications for invasive gastrointestinal procedures.
Article
Biochemistry & Molecular Biology
Meng Wang, Haotian Ma, Siyu Guan, Tao Luo, Chunchao Zhao, Guiping Cai, Yubin Zheng, Xiaoyun Jia, Jianbing Di, Runzhi Li, Hongli Cui
Summary: The study evaluated the effects of astaxanthin (AST) on high-fat diet-fed mice, demonstrating that AST supplementation can reduce body weight, modulate serum lipid levels, adjust liver function, and improve gut microbiota dysbiosis. These findings reveal a new function of AST in regulating lipid metabolism, providing a theoretical basis for the development of high-quality AST functional food.
Article
Nutrition & Dietetics
Yu Ra Lee, Hye-Bin Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Park
Summary: This study found that thyme extract can alleviate obesity and gut derangements caused by a high-fat diet. It can reduce weight gain and body fat percentage, regulate serum biomarkers associated with obesity, and improve intestinal barrier function and colon shortening. Additionally, thyme extract can alter the levels of metabolites.
Article
Nutrition & Dietetics
Na Xiao, Tengfei Zhang, Mingli Han, Dan Tian, Jiawei Liu, Shan Li, Lele Yang, Guojun Pan
Summary: Chlorogenic acid (CGA) has been found to regulate glucose and lipid metabolism. In this study, the protective effects of CGA on glucagon-induced hepatic glucose production were investigated. CGA treatment lowered the levels of glucose production in mice and also prevented glucose and ceramide accumulation in high-fat diet (HFD)-fed mice. CGA inhibited the inflammation response and prevented hepatic gluconeogenesis by inhibiting ceramide accumulation and p38 MAPK expression.
Article
Environmental Sciences
Hanqing Sun, Na Chen, Xiaona Yang, Yankai Xia, Di Wu
Summary: Exposure to polyethylene microplastics reduced colon mucin production and increased amino acid metabolism by altering colon microflora composition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Cifeng Cai, Wenwen Cheng, Tiantian Shi, Yueling Liao, Meiliang Zhou, Zhiyong Liao
Summary: This study investigated the effects of rutin on diabetes and diabetes-related colon lesions in mice by regulating gut microbiota. The results showed that rutin lowered blood glucose, improved blood lipid profile and inflammatory markers, and significantly alleviated colon lesions. Moreover, rutin regulated gut microbiota dysbiosis, increasing beneficial bacteria and decreasing diabetes-related bacteria. These findings suggest that rutin may alleviate diabetes symptoms by regulating gut microbiota.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Leming Xiao, Chengrui Liang, Jing Gao, Yin Wang, Yanzi Guo, Kan Chen, Xiaoyuan Jia
Summary: The study demonstrated that cefminox sodium (CMNX) has a therapeutic effect on fatty accumulation in animal and cell models. CMNX reduced fatty liver in mice on a high-fat high-sugar diet and alleviated fatty accumulation in liver cells. The mechanism behind this effect involves inhibition of fatty acid synthesis and facilitation of fatty acid oxidation.
Article
Biochemistry & Molecular Biology
S. M. Khaledur Rahman, Sumire Sasaki, Toru Uyama, Zahir Hussain, Mohammad Mamun Sikder, Hiroyuki Saiga, Mari Ohmura-Hoshino, Ken-ichi Ohta, Yoshimi Miki, Katsuaki Hoshino, Masaki Ueno, Makoto Murakami, Natsuo Ueda
Summary: The deficiency of PLAAT1 in mice can alleviate HFD-induced obesity and hepatic lipid accumulation, and improve lipid metabolism disorders. PLAAT1 may function as a phospholipase A(1)/A(2) in the liver, and its expression is increased by HFD treatment in wild-type mice.
Article
Nutrition & Dietetics
Gangzheng Wang, Chengyuan Sun, Bojun Xie, Tao Wang, Hongwei Liu, Xianglian Chen, Qiuju Huang, Chenghua Zhang, Taihui Li, Wangqiu Deng
Summary: CGLC reduced body weight and fat accumulation in mice on a high-fat diet, improved glucose tolerance and blood lipid levels, and treated obesity and non-alcoholic fatty liver by regulating gut microbiota, SCFAs, and genes involved in fat and lipid metabolism.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Yan Wang, Abdelfattah Z. M. Salem, Zhiliang Tan, Jinhe Kang, Zheng Wang
Summary: The study found that feeding goats a high-concentrate diet for 5 weeks resulted in significant changes in antioxidant parameters and gene expression in the liver, including downregulation of antioxidant responses and upregulation of GSTM1, as well as increased nuclear translocation of the glucocorticoid receptor.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
