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Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

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A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

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Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

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OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

(2019) R.R. Bannuru et al.   OSTEOARTHRITIS AND CARTILAGE

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(2019) Marc C. Hochberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

(2019) Philip G. Conaghan et al.   ANNALS OF INTERNAL MEDICINE

Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)

(2018) R-K. Zhang et al.   Bone & Joint Research

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

(2017) Bruno R da Costa et al.   LANCET

Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis

(2017) Yachuan Zhou et al.   Current Rheumatology Reports

Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium

(2016) Virginia Byers Kraus et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials

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(2015) Emmert Roberts et al.   ANNALS OF THE RHEUMATIC DISEASES

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

(2015) S. Thysen et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI Clinical Trials Recommendations: Design, conduct, and reporting of clinical trials for knee osteoarthritis

(2015) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Unilateral vs bilateral symptomatic knee osteoarthritis: associations between pain intensity and function

(2013) D. L. Riddle et al.   RHEUMATOLOGY

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

It's Good to Feel Better But It's Better To Feel Good and Even Better to Feel Good as Soon as Possible for as Long as Possible. Response Criteria and the Importance of Change at OMERACT 10

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Fibromyalgia Criteria and Severity Scales for Clinical and Epidemiological Studies: A Modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia

(2011) F. WOLFE et al.   JOURNAL OF RHEUMATOLOGY

Practical and Statistical Considerations in Designing an Early Phase II Osteoarthritis Clinical Trial: A Case Study

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(2009) N. Butoescu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

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