Enantioselective C2-Allylation of Benzimidazoles Using 1,3-Diene Pronucleophiles

Construction of All-Carbon Quaternary Stereocenters by Scandium-Catalyzed Intramolecular C–H Alkylation of Imidazoles with 1,1-Disubstituted Alkenes

(2020) Shao-Jie Lou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition

(2020) Richard Y. Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis

(2020) Yuxuan Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-Catalyzed Regioselective C–H Alkylation of Benzimidazoles with Aromatic Alkenes

(2020) Yu-Ting He et al.   ORGANIC LETTERS

CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications

(2019) Chengxi Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence

(2019) Yuxuan Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engaging Aldehydes in CuH-Catalyzed Reductive Coupling Reactions: Stereoselective Allylation with Unactivated 1,3-Diene Pronucleophiles

(2019) Chengxi Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Olefin Hydrocyanation without Cyanide

(2019) Alexander W. Schuppe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes

(2018) Yujing Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Ni–Al Bimetallic Catalyzed exo-Selective C–H Cyclization of Imidazoles with Alkenes

(2018) Yin-Xia Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Aluminum-Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold

(2018) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

I2-Mediated Intramolecular C–H Amidation for the Synthesis of N-Substituted Benzimidazoles

(2017) Zhiyuan Hu et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective CuH-Catalyzed Hydroacylation Employing Unsaturated Carboxylic Acids as Aldehyde Surrogates

(2017) Yujing Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Synthesis of Benzimidazoles, Quinoxalines, and Benzoxazoles from Primary Amines by ortho-Quinone Catalysis

(2017) Ruipu Zhang et al.   ORGANIC LETTERS

Chiral benzimidazoles and their applications in stereodiscrimination processes

(2017) Vaibhav N. Khose et al.   TETRAHEDRON-ASYMMETRY

Benzimidazoles: A biologically active compounds

(2017) Salahuddin et al.   Arabian Journal of Chemistry

Regiodivergent and Diastereoselective CuH-Catalyzed Allylation of Imines with Terminal Allenes

(2016) Richard Y. Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department

(2016) Anna-Karin Sohlenius-Sternbeck et al.   CURRENT DRUG METABOLISM

Copper(II)-Catalyzed Oxidative Cross-Coupling of Anilines, Primary Alkyl Amines, and Sodium Azide Using TBHP: A Route to 2-Substituted Benzimidazoles

(2016) Devulapally Mahesh et al.   JOURNAL OF ORGANIC CHEMISTRY

Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2-Aminobenzylamines

(2016) Santanu Hati et al.   ORGANIC LETTERS

Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes

(2015) Michael T. Pirnot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a novel class of potent and selective FIXa inhibitors

(2015) Ting Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Copper(I)-Catalyzed Regioselective Amination of N-Aryl Imines Using TMSN3 and TBHP: A Route to Substituted Benzimidazoles

(2015) Devulapally Mahesh et al.   JOURNAL OF ORGANIC CHEMISTRY

A Facile Synthesis of 2-Aminobenzoxazoles and 2-Aminobenzimidazoles Using N-Cyano-N-phenyl-p-toluenesulfonamide (NCTS) as an Efficient Electrophilic Cyanating Agent

(2015) Mahesh Kasthuri et al.   SYNLETT

Sodium Sulfide: A Sustainable Solution for Unbalanced Redox Condensation Reaction between o-Nitroanilines and Alcohols Catalyzed by an Iron–Sulfur System

(2015) Thanh Nguyen et al.   SYNTHESIS-STUTTGART

Atom-Economic, Regiodivergent, and Stereoselective Coupling of Imidazole Derivatives with Terminal Allenes

(2014) Kun Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

(2014) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Solvent/Oxidant-Switchable Synthesis of Multisubstituted Quinazolines and Benzimidazoles via Metal-Free Selective Oxidative Annulation of Arylamidines

(2014) Jian-Ping Lin et al.   ORGANIC LETTERS

In situ Catalytic Generation of Allylcopper Species for Asymmetric Allylation: Toward 1H-Isochromene Skeletons

(2013) Junya Kawai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Intermolecular Regioselective Hydroamination of Styrenes with Polymethylhydrosiloxane and Hydroxylamines

(2013) Yuya Miki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes

(2013) Shaolin Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO

(2013) Hannah Baars et al.   ORGANIC LETTERS

Cobalt- and Iron-Catalyzed Redox Condensation of o-Substituted Nitrobenzenes with Alkylamines: A Step- and Redox-Economical Synthesis of Diazaheterocycles

(2013) Thanh Binh Nguyen et al.   ORGANIC LETTERS

Iodobenzene Catalyzed C–H Amination of N-Substituted Amidines Using m-Chloroperbenzoic Acid

(2013) Santhosh Kumar Alla et al.   ORGANIC LETTERS

Functionalized Orthoesters as Powerful Building Blocks for the Efficient Preparation of Heteroaromatic Bicycles

(2012) Gulluzar Bastug et al.   ORGANIC LETTERS

Benzazoles from Aliphatic Amines and o-Amino/Mercaptan/Hydroxyanilines: Elemental Sulfur as a Highly Efficient and Traceless Oxidizing Agent

(2012) Thanh Binh Nguyen et al.   ORGANIC LETTERS

Copper-Catalyzed, One-Pot, Three-Component Synthesis of Benzimidazoles by Condensation and C–N Bond Formation

(2011) Yong Kim et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

(2009) Andy S. Tsai et al.   CHEMICAL COMMUNICATIONS

Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)

(2009) Shigeo Hayashi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regio- and EnantioselectiveN-Allylations of Imidazole, Benzimidazole, and Purine Heterocycles Catalyzed by Single-Component Metallacyclic Iridium Complexes

(2009) Levi M. Stanley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mild and Highly Efficient Method for the Synthesis of 2-Arylbenzimidazoles and 2-Arylbenzothiazoles

(2008) Kiumars Bahrami et al.   JOURNAL OF ORGANIC CHEMISTRY