Dual role for angiotensin‐converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat

The Other Angiotensin II Receptor: AT2R as a Therapeutic Target

(2020) Lucienne Juillerat-Jeanneret   JOURNAL OF MEDICINAL CHEMISTRY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Cardiac Repair: the intricate crosstalk between the epicardium and the myocardium

(2020) Laura Pellegrini et al.   Current Stem Cell Research & Therapy

The Vasoactive Mas Receptor in Essential Hypertension

(2020) Amalie L. Povlsen et al.   Journal of Clinical Medicine

Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults

(2020) Katherine Mackey et al.   ANNALS OF INTERNAL MEDICINE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

(2020) Daniel Batlle et al.   CLINICAL SCIENCE

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

Does epicardial fat contribute to COVID-19 myocardial inflammation?

(2020) Alexis Elias Malavazos et al.   EUROPEAN HEART JOURNAL

Epicardial adipose tissue: fuel for COVID-19-induced cardiac injury?

(2020) In-Cheol Kim et al.   EUROPEAN HEART JOURNAL

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

The generation of immune‐induced fever and emotional stress‐induced hyperthermia in mice does not involve brown adipose tissue thermogenesis

(2020) Anna Eskilsson et al.   FASEB JOURNAL

Nasal ACE2 Levels and COVID-19 in Children

(2020) Ankit B. Patel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19

(2020) Hao Cheng et al.   JOURNAL OF MEDICAL VIROLOGY

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Obesity and impaired metabolic health in patients with COVID-19

(2020) Norbert Stefan et al.   Nature Reviews Endocrinology

The COVID-19 outbreak and the angiotensin-converting enzyme 2: too little or too much?

(2020) Marie Essig et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Does high cardiorespiratory fitness confer some protection against pro‐inflammatory responses after infection by SARS‐CoV‐2?

(2020) Hermann Zbinden‐Foncea et al.   Obesity

Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB

(2020) Juan Simon Rico-Mesa et al.   Current Cardiology Reports

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis

(2020) Israel Júnior Borges do Nascimento et al.   Journal of Clinical Medicine

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes

(2020) Alexander G. Obukhov et al.   DIABETES

Angiotensin‐converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID‐19 infection in a multi‐site UK acute hospital trust

(2020) Daniel M. Bean et al.   EUROPEAN JOURNAL OF HEART FAILURE

SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

(2020) Sonja Groß et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin‐(1‐7) and Obesity: Role on cardiorespiratory fitness and COVID‐19 implications

(2020) Daisy Motta‐Santos et al.   Obesity

The renin–angiotensin–aldosterone system as a link between obesity and coronavirus disease 2019 severity

(2020) Ioannis Akoumianakis et al.   Obesity Reviews

ACE2 and COVID-19 and the resulting ARDS

(2020) Xiaoqing Zhang et al.   POSTGRADUATE MEDICAL JOURNAL

Epicardial Adipose Tissue and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction

(2020) Thomas M. Gorter et al.   JACC-Heart Failure

The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials

(2020) Eugenie R. Lumbers et al.   Frontiers in Medicine

Increase in COVID-19 inpatient survival following detection of Thromboembolic and Cytokine storm risk from the point of admission to hospital by a near real time Traffic-light System (TraCe-Tic)

(2020) Marcela P. Vizcaychipi et al.   Brazilian Journal of Infectious Diseases

Hypertrophic Adipocyte–Derived Exosomal miR‐802‐5p Contributes to Insulin Resistance in Cardiac Myocytes Through Targeting HSP60

(2020) Zhongyuan Wen et al.   Obesity

Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships

(2020) Barry M. Popkin et al.   Obesity Reviews

Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak

(2020) Daniel O. Griffin et al.   Journal of Global Antimicrobial Resistance

Epicardial fat accumulation is an independent marker of impaired heart rate recovery in obese patients with obstructive sleep apnea

(2019) Astrid Monfort et al.   Clinical Research in Cardiology

The Renin-Angiotensin System: Going Beyond the Classical Paradigms

(2019) Robson A. Souza Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction

(2019) Masaru Obokata et al.   JACC-Cardiovascular Imaging

Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice

(2019) Robin Shoemaker et al.   Biology of Sex Differences

ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue

(2019) Yasuhiro Kawabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Analysis of long non-coding RNA and mRNA profiles in epicardial adipose tissue of patients with atrial fibrillation

(2019) Lei Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects

(2018) Markus Goeller et al.   Journal of Cardiovascular Computed Tomography

Epicardial Adipose Tissue feeding and overfeeding the Heart

(2018) Gianluca Iacobellis et al.   NUTRITION

Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease

(2017) Vaibhav B. Patel et al.   HEART FAILURE REVIEWS

Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction

(2017) Michael M. Givertz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor

(2017) U. Muscha Steckelings et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue

(2017) Kanta Chechi et al.   Scientific Reports

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity

(2016) Vaibhav B. Patel et al.   Adipocyte

Administration of 17β-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism

(2015) Yu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

(2015) Labros S. Sidossis et al.   Cell Metabolism

Protecting the Heart in Obesity: Role of ACE2 and Its Partners

(2015) Rhian M. Touyz   DIABETES

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease

(2014) Wang Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Heart failure with preserved ejection fraction

(2014) James D. Gladden et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index

(2014) Ravi V. Shah et al.   JACC-Cardiovascular Imaging

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

(2013) Manuel Haschke et al.   CLINICAL PHARMACOKINETICS

ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke

(2013) Teng Jiang et al.   Current Neuropharmacology

Adult Epicardial Fat Exhibits Beige Features

(2013) Harold S. Sacks et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats

(2013) Quaisar Ali et al.   KIDNEY INTERNATIONAL

ACE2 alterations in kidney disease

(2013) M. J. Soler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LPS activates ADAM9 dependent shedding of ACE from endothelial cells

(2012) William R. English et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of angiotensin II receptors beyond the classical pathway

(2012) Masatsugu Horiuchi et al.   CLINICAL SCIENCE

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2

(2010) JiuChang Zhong et al.   HYPERTENSION

Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors

(2009) Mao-liang Huang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

(2009) G. Y. Oudit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Fatty Acid Composition of Epicardial and Subcutaneous Human Adipose Tissue

(2009) Masoud Pezeshkian et al.   Metabolic Syndrome and Related Disorders

ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet

(2008) Manisha Gupte et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart

(2008) Paul J. Garabelli et al.   EXPERIMENTAL PHYSIOLOGY