Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
Authors
Keywords
-
Journal
NUCLEIC ACIDS RESEARCH
Volume 49, Issue 4, Pages 1828-1839
Publisher
Oxford University Press (OUP)
Online
2021-02-04
DOI
10.1093/nar/gkab047
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine
- (2020) Atsushi Mikami et al. NUCLEIC ACIDS RESEARCH
- Selective tissue targeting of synthetic nucleic acid drugs
- (2019) Punit P. Seth et al. JOURNAL OF CLINICAL INVESTIGATION
- Re-Engineering RNA Molecules into Therapeutic Agents
- (2019) Martin Egli et al. ACCOUNTS OF CHEMICAL RESEARCH
- Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
- (2019) Wen Shen et al. NATURE BIOTECHNOLOGY
- Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
- (2019) Michael T Migawa et al. NUCLEIC ACIDS RESEARCH
- RNA-Targeted Therapeutics
- (2018) Stanley T. Crooke et al. Cell Metabolism
- Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
- (2017) Mark K. Schlegel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cellular uptake and trafficking of antisense oligonucleotides
- (2017) Stanley T Crooke et al. NATURE BIOTECHNOLOGY
- Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides
- (2017) Michael E. Østergaard et al. Molecular Therapy-Nucleic Acids
- The Medicinal Chemistry of Therapeutic Oligonucleotides
- (2016) W. Brad Wan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides
- (2016) Alexander V. Kel′in et al. JOURNAL OF ORGANIC CHEMISTRY
- Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA
- (2016) Robert D. Giacometti et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
- (2015) Thazha P. Prakash et al. NUCLEIC ACIDS RESEARCH
- Differential Effects on Allele Selective Silencing of Mutant Huntingtin by Two Stereoisomers of α,β-Constrained Nucleic Acid
- (2014) Michael E. Østergaard et al. ACS Chemical Biology
- Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
- (2013) Michael E. Østergaard et al. NUCLEIC ACIDS RESEARCH
- Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angleγ
- (2012) Stephen Hanessian et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and chemistry
- (2012) Sue Murray et al. NUCLEIC ACIDS RESEARCH
- Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
- (2012) Punit P Seth et al. Molecular Therapy-Nucleic Acids
- Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S- and R-6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid
- (2011) Pradeep S. Pallan et al. BIOCHEMISTRY
- Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNA
- (2011) Punit P. Seth et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- α,β-D-CNA featuring canonical and noncanonical α/β torsional angles behaviours within oligonucleotides
- (2011) Arnaud Boissonnet et al. NEW JOURNAL OF CHEMISTRY
- Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides
- (2010) Punit P. Seth et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitsunobu and Related Reactions: Advances and Applications
- (2009) K. C. Kumara Swamy et al. CHEMICAL REVIEWS
- Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles
- (2008) Pradeep S. Pallan et al. CHEMICAL COMMUNICATIONS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started