Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals

(2013) Thazha P. Prakash et al.   ACS Chemical Biology

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

(2013) Mark J. Graham et al.   CIRCULATION RESEARCH

RNAi in Clinical Studies

(2013) P. Kubowicz et al.   CURRENT MEDICINAL CHEMISTRY

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

(2012) Dongbo Yu et al.   CELL

Single-Stranded siRNAs Activate RNAi in Animals

(2012) Walt F. Lima et al.   CELL

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

5′,6′-Nucleoside Phosphonate Analogues Architecture: Synthesis and Comparative Evaluation towards Metabolic Enzymes

(2011) Franck Gallier et al.   ChemMedChem

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides

(2010) Punit P. Seth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationship of (N)-Methanocarba Phosphonate Analogues of 5′-AMP as Cardioprotective Agents Acting Through a Cardiac P2X Receptor

(2010) T. Santhosh Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

(2010) Punit P. Seth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

(2009) Yanli Wang et al.   NATURE

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

(2009) Timothy A. Vickers et al.   NUCLEIC ACIDS RESEARCH

Developing an efficient route to the synthesis of nucleoside 1-alkynylphosphonates

(2009) Maïa Meurillon et al.   TETRAHEDRON

Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

(2008) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

(2008) Yanli Wang et al.   NATURE