Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

(2019) Susan McQuown et al.   Frontiers in Molecular Neuroscience

Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons

(2019) Elisabeth Piccart et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum

(2019) Dahdjim B Betolngar et al.   CEREBRAL CORTEX

A Novel Phosphodiesterase 1 Inhibitor DSR-141562 Exhibits Efficacies in Animal Models for Positive, Negative, and Cognitive Symptoms Associated with Schizophrenia

(2019) Takeshi Enomoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance

(2018) Anton Pekcec et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease

(2018) Yinuo Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations

(2018) P.R.A. Heckman et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task

(2018) Samuel A. Barnes et al.   PSYCHOPHARMACOLOGY

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

(2017) Brian Dyck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition

(2016) Masanori Miyauchi et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding

(2016) S.A. Barnes et al.   BEHAVIOURAL BRAIN RESEARCH

Towards the development of improved tests for negative symptoms of schizophrenia in a validated animal model

(2016) Ceren Sahin et al.   BEHAVIOURAL BRAIN RESEARCH

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

(2016) Peng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

(2016) Gretchen L. Snyder et al.   PSYCHOPHARMACOLOGY

Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents

(2015) Ben Grayson et al.   BEHAVIOURAL BRAIN RESEARCH

Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

(2015) Nao J. Gamo et al.   BIOLOGICAL PSYCHIATRY

Past, present and future of spike sorting techniques

(2015) Hernan Gonzalo Rey et al.   BRAIN RESEARCH BULLETIN

Impaired Attention and Synaptic Senescence of the Prefrontal Cortex Involves Redox Regulation of NMDA Receptors

(2015) M. Guidi et al.   JOURNAL OF NEUROSCIENCE

Hyperresponsivity and impaired prefrontal control of the mesolimbic reward system in schizophrenia

(2015) Anja Richter et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia

(2015) Sailaja A. Goda et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia

(2015) Sanna K. Janhunen et al.   PSYCHOPHARMACOLOGY

Comparing the effects of subchronic phencyclidine and medial prefrontal cortex dysfunction on cognitive tests relevant to schizophrenia

(2015) K. A. L. McAllister et al.   PSYCHOPHARMACOLOGY

Impaired Limbic Cortico-Striatal Structure and Sustained Visual Attention in a Rodent Model of Schizophrenia

(2015) S. A. Barnes et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Too Little and Too Much: Hypoactivation and Disinhibition of Medial Prefrontal Cortex Cause Attentional Deficits

(2014) M. Pezze et al.   JOURNAL OF NEUROSCIENCE

Acute and chronic effects of NMDA receptor antagonists in rodents, relevance to negative symptoms of schizophrenia: A translational link to humans

(2013) Joanna C. Neill et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Presynaptic kainate receptor-mediated facilitation of glutamate release involves Ca2+-calmodulin and PKA in cerebrocortical synaptosomes

(2013) Antonio Rodríguez-Moreno et al.   FEBS LETTERS

Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons

(2012) Nadezhda V. Povysheva et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

(2012) Amy F.T. Arnsten et al.   NEURON

Standardizing the use of the Continuous Performance Test in schizophrenia research: A validation study

(2012) Phoebe V. Kahn et al.   SCHIZOPHRENIA RESEARCH

The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder

(2011) Natalia del Campo et al.   BIOLOGICAL PSYCHIATRY

Animal models of schizophrenia

(2011) CA Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT1A Receptor-Dependent Mechanism

(2011) Lucila Kargieman et al.   NEUROPSYCHOPHARMACOLOGY

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

(2010) Akinori Nishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

PD168077, a D4 receptor agonist, reverses object recognition deficits in rats: potential role for D4 receptor mechanisms in improving cognitive dysfunction in schizophrenia

(2010) Pooja Sood et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration

(2010) Emma S. Lydall et al.   PSYCHOPHARMACOLOGY

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

(2010) David M. Thomson et al.   PSYCHOPHARMACOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor

(2009) Rahul Deshmukh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cyclic nucleotide analogs as probes of signaling pathways

(2008) Heiko Poppe et al.   NATURE METHODS

The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats

(2008) Andrea Bari et al.   Nature Protocols

Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration

(2008) Nurith Amitai et al.   PSYCHOPHARMACOLOGY