Evaluating high-throughput scale-down chromatography platforms for increased process understanding

A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies

(2014) John P. Welsh et al.   BIOTECHNOLOGY PROGRESS

Chromatography process development in the quality by design paradigm I: Establishing a high-throughput process development platform as a tool for estimating “characterization space” for an ion exchange chromatography step

(2013) R. Bhambure et al.   BIOTECHNOLOGY PROGRESS

High-throughput process development of chromatography steps: Advantages and limitations of different formats used

(2012) Karol M. Łącki   Biotechnology Journal

High-throughput methods for miniaturization and automation of monoclonal antibody purification processes

(2012) Katrin Treier et al.   BIOTECHNOLOGY PROGRESS

Strategic assay deployment as a method for countering analytical bottlenecks in high throughput process development: Case studies in ion exchange chromatography

(2012) Spyridon Konstantinidis et al.   BIOTECHNOLOGY PROGRESS

Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein

(2011) Mairead Looby et al.   BIOTECHNOLOGY PROGRESS

Review: Microscale methods for high-throughput chromatography development in the pharmaceutical industry

(2009) Sunil Chhatre et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

High-throughput screening of chromatographic separations: I. Method development and column modeling

(2008) Jonathan L. Coffman et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-Throughput Process Development: Determination of Dynamic Binding Capacity Using Microtiter Filter Plates Filled with Chromatography Resin

(2008) T. Bergander et al.   BIOTECHNOLOGY PROGRESS

High Throughput Screening for the Design and Optimization of Chromatographic Processes – Miniaturization, Automation and Parallelization of Breakthrough and Elution Studies

(2008) M. Wiendahl et al.   CHEMICAL ENGINEERING & TECHNOLOGY