SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class

Involvement of necroptosis and ferroptosis pathway signaling in Hemiscorpius lepturus venom -induced acute kidney injury

(2019) Rana Dizaji et al.   TOXICON

Coenzyme Q10 Alleviated Behavioral Dysfunction and Bioenergetic Function in an Animal Model of Depression

(2019) Sina Andalib et al.   NEUROCHEMICAL RESEARCH

Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis

(2018) Rita Citraro et al.   CURRENT PHARMACEUTICAL DESIGN

Histone deacetylases (HDACs) as therapeutic target for depressive disorders

(2018) Paulina Misztak et al.   Pharmacological Reports

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

(2018) Chadi G. Abdallah et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

The Limbic System in Youth Depression: Brain Structural and Functional Alterations in Adolescent In-patients with Severe Depression

(2017) Ronny Redlich et al.   NEUROPSYCHOPHARMACOLOGY

Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice

(2017) Shayan Amiri et al.   NEUROSCIENCE

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

(2017) Hossein Amini-Khoei et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

(2016) Elsa M. Meylan et al.   NEUROPHARMACOLOGY

Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice

(2016) Sorabh Sharma et al.   NEUROPHARMACOLOGY

Involvement of N-methyl-d-aspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test

(2016) Nastaran Kordjazy et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

(2016) Mahsa Sadeghi et al.   PHYSIOLOGY & BEHAVIOR

The potential use of histone deacetylase inhibitors in the treatment of depression

(2016) Manabu Fuchikami et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine

(2016) Nazanin Sonei et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Major Depressive Disorder: Understanding the Significance of Residual Symptoms and Balancing Efficacy with Tolerability

(2015) Larry Culpepper et al.   AMERICAN JOURNAL OF MEDICINE

Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function

(2015) Shayan Amiri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

(2015) Hossein Amini-Khoei et al.   EPILEPSY & BEHAVIOR

Spine synapse remodeling in the pathophysiology and treatment of depression

(2015) Catharine H. Duman et al.   NEUROSCIENCE LETTERS

Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial

(2015) Meisam Sanoobar et al.   NUTRITIONAL NEUROSCIENCE

The Antidepressant Treatment Response Index as a Predictor of Reboxetine Treatment Outcome in Major Depressive Disorder

(2014) Marissa M. Caudill et al.   CLINICAL EEG AND NEUROSCIENCE

Epigenetic programming by early-life stress: Evidence from human populations

(2014) A. M. Vaiserman   DEVELOPMENTAL DYNAMICS

Mental health: A world of depression

(2014) Kerri Smith   NATURE

Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents

(2014) Mayumi Nishi et al.   Frontiers in Neuroscience

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors

(2013) Tamaki Hayase   BMC NEUROSCIENCE

Role of Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways in the Etiology of Depression: Therapeutic Implications

(2013) George Anderson et al.   CNS DRUGS

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

(2013) Adrian L. Lopresti et al.   JOURNAL OF AFFECTIVE DISORDERS

Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

(2013) Sawsan Aboul-Fotouh   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

(2013) Frederick A. Schroeder et al.   PLoS One

Mitochondrial dysfunction, oxidative stress, and major depressive disorder

(2013) Edward Tobe   Neuropsychiatric Disease and Treatment

Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation

(2012) HaoSheng Sun et al.   NEUROPSYCHOPHARMACOLOGY

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

(2012) R. S. Duman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

The Epigenetic Code in Depression: Implications for Treatment

(2011) M Schroeder et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflammatory and Neurodegenerative Pathways in Depression: A New Avenue for Antidepressant Development?

(2011) M. Catena-Dell'Osso et al.   CURRENT MEDICINAL CHEMISTRY

Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics

(2011) Christine Heim et al.   EXPERIMENTAL NEUROLOGY

Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment

(2011) Amir Levine et al.   NEUROBIOLOGY OF DISEASE

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

(2011) Shusaku Uchida et al.   NEURON

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

(2011) Patrick O. McGowan et al.   PLoS One

Maternal separation with early weaning: a novel mouse model of early life neglect

(2010) Elizabeth D George et al.   BMC NEUROSCIENCE

Epigenetics and depression: current challenges and new therapeutic options

(2010) Marc Schroeder et al.   CURRENT OPINION IN PSYCHIATRY

Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice

(2010) Nika Allami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats

(2010) Hiroya Sato et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample

(2010) M. Uddin et al.   PSYCHOLOGICAL MEDICINE

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

The hippocampus and memory: insights from spatial processing

(2008) Chris M. Bird et al.   NATURE REVIEWS NEUROSCIENCE