Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Biomedical
Juliana A. Knocikova, Tomas Petrasek
Summary: This article discusses the neurophysiological correlates of Major Depressive Disorder, describing various analytical methods from traditional to innovative, and their diagnostic relevance and practical utility.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Engineering, Biomedical
Yueheng Peng, Yang Huang, Baodan Chen, Mengling He, Lin Jiang, Yuqin Li, Xunan Huang, Changfu Pei, Shu Zhang, Cunbo Li, Xiabing Zhang, Tao Zhang, Yutong Zheng, Dezhong Yao, Fali Li, Peng Xu
Summary: This study analyzed resting-state electroencephalogram (EEG) data from patients with major depressive disorder (MDD) and found that the corresponding EEG networks weakened significantly after short-term antidepressant treatment. This change in network properties within one week of medication reliably predicted the eventual medication efficacy. Additionally, the baseline EEG networks accurately distinguished responders from non-responders with a high accuracy.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Psychology, Clinical
E. Loeb, K. El Asmar, S. Trabado, F. Gressier, R. Colle, A. Rigal, S. Martin, C. Verstuyft, B. Feve, P. Chanson, L. Becquemont, E. Corruble
Summary: This study found that depressed patients have decreased NOS activity compared to healthy controls, and it improves after antidepressant treatment. NOS activity may be a promising biomarker for major depressive episodes in the context of major depressive disorder.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Seokho Yun, Bumseok Jeong
Summary: The study investigated the presence of specific time scales characterizing major depressive disorder (MDD) by measuring refined complex multiscale permutation entropy (RCMPE) from resting-state EEG data. The results showed that signal variability at coarse temporal scales was higher in MDD patients compared to healthy controls, while there was a negative correlation between signal variability at fine temporal scales and depressive symptom severity in certain sensor areas.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Psychiatry
Yu Zhang, Lei Lei, Ziwei Liu, Mingxue Gao, Zhifen Liu, Ning Sun, Chunxia Yang, Aixia Zhang, Yikun Wang, Kerang Zhang
Summary: This study investigated the differences in EEG power spectrum at theta oscillations between patients with MDD and patients with AN. It found that AN patients demonstrated reduced power in the prefrontal cortex, left temporal lobe, and right occipital regions compared to MDD patients.Theta oscillations could potentially serve as a biomarker that distinguishes MDD from AN, pending further confirmation in future studies.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Qi Zhou, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Hongjun Tian, Kerang Zhang, Jing Wei, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Cuixia An, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu, Chuan Shi
Summary: Inflammation and cognition are related to major depressive disorder (MDD). Treatment response in MDD patients is associated with different cognitive defects, especially in speed of processing and executive function. Factors such as smoking, alcohol drinking, baseline cognitive performance, and cytokine levels may influence treatment response.
PSYCHIATRY RESEARCH
(2021)
Review
Medicine, General & Internal
Anna Mosiolek, Aleksandra Pieta, Slawomir Jakima, Natalia Zborowska, Jadwiga Mosiolek, Agata Szulc
Summary: Major depressive disorder is a prevalent mental illness worldwide, with more than 30% of patients not achieving remission through conventional therapy. Inflammation and disturbed neurogenesis are implicated in the pathophysiology of depression, with potential involvement of neurotrophic factors in patient recovery. The influence of antidepressants on inflammatory cytokines and neurotrophins remains inconsistent, with selective serotonin reuptake inhibitors, selective serotonin and noradrenaline inhibitors, and tricyclic antidepressants showing possible anti-inflammatory properties. Further research is needed to determine the role of inflammatory markers in predicting treatment response in MDD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Pablo Patricio Zarate-Garza, Jessica Alejandra Ortega-Balderas, Jose Alfonso Ontiveros-Sanchez de la Barquera, Roberto Alejandro Lugo-Guillen, Alejandro Marfil-Rivera, Alejandro Quiroga-Garza, Santos Guzman-Lopez, Rodrigo Enrique Elizondo-Omana
Summary: The study found that antidepressant-naive individuals with major depression disorder who achieved clinical remission had larger hippocampal volumes before treatment. The findings suggest that HV may serve as a predictor of treatment outcomes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Leutner Michael, Matzhold Caspar, Kautzky Alexander, Kaleta Michaela, Thurner Stefan, Klimek Peter, Kautzky-Willer Alexandra
Summary: This study found that there was a higher proportion of MDD among patients treated with statins compared to non-treated patients, with a dose-dependent relationship between statins and the diagnosis of MDD. Low-dose statin treatment was associated with a lower risk of MDD, while high-dose statin treatment was associated with a higher risk of MDD.
FRONTIERS IN MEDICINE
(2021)
Article
Psychology, Clinical
Marcelo T. Berlim, Stephane Richard-Devantoy, Nicole Rodrigues dos Santos, Gustavo Turecki
Summary: The study found that the psychopathological network structure of major depressive disorder changed after 8 weeks of antidepressant treatment, showing increased interconnectedness. Throughout the treatment process, the core symptoms of major depressive disorder include depressed mood, fatigue, and cognitive/psychomotor disturbance.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
G. Pineau, E. Jean, L. Romo, F. Villemain, D. Poupon, P. Gorwood
Summary: A longitudinal pilot study found that skin conductance response (SCR) after antidepressant treatment initiation may help predict treatment efficacy in patients with major depression. Responders showed higher SCR at day 7 for emotional stimuli, with a strong positive predictive value for antidepressant efficacy.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Lei Zhao, Donglin Wang, Shao-Wei Xue, Zhonglin Tan, Hong Luo, Yan Wang, Hanxiaoran Li, Chenyuan Pan, Sufen Fu, Xiwen Hu, Zhihui Lan, Yang Xiao, Changxiao Kuai
Summary: Deficits in emotion regulation are key features of major depressive disorder (MDD) and targeting the dynamic functional connectivity of emotion networks could be an important clinical intervention for treating MDD. The study found that antidepressant treatment led to a reconfiguration of emotion regulation networks in MDD patients, and stronger baseline dFC can predict a faster reduction in depression scores.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Taylor A. Braund, Isabella A. Breukelaar, Kristi Griff, Gabriel Tillman, Donna M. Palmer, Richard Bryant, Mary L. Phillips, Anthony W. F. Harris, Mayuresh S. Korgaonkar
Summary: This study found that neuroticism is associated with the organization of intrinsic neural networks that can predict treatment outcomes, providing an opportunity for personalized treatment.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)