Direct Reprogramming of Somatic Cells to Neurons: Pros and Cons of Chemical Approach

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

(2020) Jeffrey S. Schweitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuronal Reprogramming for Tissue Repair and Neuroregeneration

(2020) Roxanne Hsiang-Chi Liou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

(2020) Hyunah Lee et al.   eLife

Author Correction: Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2020) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Xeno- and transgene-free reprogramming of mesenchymal stem cells toward the cells expressing neural markers using exosome treatments

(2020) Luis Sebástian Alexis Valerio et al.   PLoS One

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Non-viral Gene Delivery Methods for Bone and Joints

(2020) Benjamin Gantenbein et al.   Frontiers in Bioengineering and Biotechnology

Chemical Conversion of Human Fetal Astrocytes into Neurons through Modulation of Multiple Signaling Pathways

(2019) Jiu-Chao Yin et al.   Stem Cell Reports

Direct cell reprogramming for tissue engineering and regenerative medicine

(2019) Alexander Grath et al.   Journal of Biological Engineering

Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

(2019) Begüm Aydin et al.   NATURE NEUROSCIENCE

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

(2019) Joseph Herdy et al.   eLife

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

(2019) Audrey Chabrat et al.   Stem Cells International

Direct reprogramming into interneurons: potential for brain repair

(2019) Maria Pereira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amyloid-β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation

(2019) Jing Lu et al.   Current Alzheimer Research

Next‐generation disease modeling with direct conversion: a new path to old neurons

(2019) Larissa Traxler et al.   FEBS LETTERS

Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules

(2019) Yaming Yang et al.   Stem Cell Reports

Transdifferentiation of human adult peripheral blood T cells into neurons

(2018) Koji Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

(2018) Yongsung Kim et al.   Cell Reports

Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules

(2018) Christopher Lee et al.   ACS Chemical Neuroscience

Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

(2018) Kai Yao et al.   NATURE

Diverse reprogramming codes for neuronal identity

(2018) Rachel Tsunemoto et al.   NATURE

Transdifferentiation: a new promise for neurodegenerative diseases

(2018) Cristiana Mollinari et al.   Cell Death & Disease

New Technologies To Enhance In Vivo Reprogramming for Regenerative Medicine

(2018) Jacqueline Larouche et al.   TRENDS IN BIOTECHNOLOGY

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

(2017) Yu Tang et al.   Frontiers in Molecular Neuroscience

Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules

(2017) Longfei Gao et al.   Stem Cell Reports

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

(2016) Hedong Li et al.   NEURON

Rapid and efficient gene delivery into the adult mouse brain via focal electroporation

(2016) Tadashi Nomura et al.   Scientific Reports

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

(2016) Meng-Lu Liu et al.   Cell Reports

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

(2016) Lei-Lei Wang et al.   Cell Reports

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

Small molecules increase direct neural conversion of human fibroblasts

(2016) Ulrich Pfisterer et al.   Scientific Reports

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons

(2015) Lei Zhang et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity

(2015) Jong-Hee Lee et al.   Cell Reports

Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

(2014) Alejandro Sánchez Alvarado et al.   CELL

Generation of neural progenitor cells by chemical cocktails and hypoxia

(2014) Lin Cheng et al.   CELL RESEARCH

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

(2014) Soham Chanda et al.   Stem Cell Reports

A CRISPR/Cas9-Based System for Reprogramming Cell Lineage Specification

(2014) Syandan Chakraborty et al.   Stem Cell Reports

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells

(2013) Saiyong Zhu et al.   CELL RESEARCH

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Direct reprogramming of human astrocytes into neural stem cells and neurons

(2012) Stefania Corti et al.   EXPERIMENTAL CELL RESEARCH

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Generation of integration-free neural progenitor cells from cells in human urine

(2012) Lihui Wang et al.   NATURE METHODS

Cellular Reprogramming Employing Recombinant Sox2 Protein

(2012) Marc Thier et al.   Stem Cells International

Historical Origins of Transdifferentiation and Reprogramming

(2011) Thomas Graf   Cell Stem Cell

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

(2010) Jochen De Vry et al.   MOLECULAR THERAPY

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY