Optical control of fast and processive engineered myosins in vitro and in living cells

Molecular mechanism for direct actin force-sensing by α-catenin

(2020) Lin Mei et al.   eLife

A fluorogenic array for temporally unlimited single-molecule tracking

(2019) Rajarshi P. Ghosh et al.   Nature Chemical Biology

Directionality of dynein is controlled by the angle and length of its stalk

(2019) Sinan Can et al.   NATURE

Controlling organization and forces in active matter through optically defined boundaries

(2019) Tyler D. Ross et al.   NATURE

Re-engineering of protein motors to understand mechanisms biasing random motion and generating collective dynamics

(2018) Ken’ya Furuta et al.   CURRENT OPINION IN BIOTECHNOLOGY

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Harnessing molecular motors for nanoscale pulldown in live cells

(2017) Jonathan E. Bird et al.   MOLECULAR BIOLOGY OF THE CELL

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons

(2017) Wenjing Wang et al.   NATURE BIOTECHNOLOGY

Controllable molecular motors engineered from myosin and RNA

(2017) Tosan Omabegho et al.   Nature Nanotechnology

Investigations of human myosin VI targeting using optogenetically controlled cargo loading

(2017) Alexander R. French et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

A Phytochrome-Derived Photoswitch for Intracellular Transport

(2017) Max Adrian et al.   ACS Synthetic Biology

A pipeline approach to single-particle processing inRELION

(2017) Rafael Fernandez-Leiro et al.   Acta Crystallographica Section D-Structural Biology

Light-controlled intracellular transport in Caenorhabditis elegans

(2016) Martin Harterink et al.   CURRENT BIOLOGY

KymographClear and KymographDirect: two tools for the automated quantitative analysis of molecular and cellular dynamics using kymographs

(2016) Pierre Mangeol et al.   MOLECULAR BIOLOGY OF THE CELL

Creating biomolecular motors based on dynein and actin-binding proteins

(2016) Akane Furuta et al.   Nature Nanotechnology

Parallel computation with molecular-motor-propelled agents in nanofabricated networks

(2016) Dan V. Nicolau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin X motor is optimized for movement on actin bundles

(2016) Virginie Ropars et al.   Nature Communications

Engineered kinesin motor proteins amenable to small-molecule inhibition

(2016) Martin F. Engelke et al.   Nature Communications

Improving brightness and photostability of green and red fluorescent proteins for live cell imaging and FRET reporting

(2016) Bryce T. Bajar et al.   Scientific Reports

An Information-Based Approach to Change-Point Analysis with Applications to Biophysics and Cell Biology

(2015) Paul A. Wiggins   BIOPHYSICAL JOURNAL

Optogenetic Control of Molecular Motors and Organelle Distributions in Cells

(2015) Liting Duan et al.   CHEMISTRY & BIOLOGY

Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization

(2015) Edward R. Ballister et al.   CURRENT BIOLOGY

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

(2015) L. J. Bugaj et al.   Nature Communications

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

(2015) Tural Aksel et al.   Cell Reports

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

Structure of human cytoplasmic dynein-2 primed for its power stroke

(2014) Helgo Schmidt et al.   NATURE

Gold rotor bead tracking for high-speed measurements of DNA twist, torque and extension

(2014) Paul Lebel et al.   NATURE METHODS

Remote control of myosin and kinesin motors using light-activated gearshifting

(2014) Muneaki Nakamura et al.   Nature Nanotechnology

Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli

(2013) David Oyen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Engineering myosins for long-range transport on actin filaments

(2013) Tony D. Schindler et al.   Nature Nanotechnology

The myosin superfamily at a glance

(2012) M. A. Hartman et al.   JOURNAL OF CELL SCIENCE

Predictive-focus illumination for reducing photodamage in live-cell microscopy

(2012) Z. SCHILLING et al.   JOURNAL OF MICROSCOPY

Engineering controllable bidirectional molecular motors based on myosin

(2012) Lu Chen et al.   Nature Nanotechnology

Subversion of the actin cytoskeleton during viral infection

(2011) Matthew P. Taylor et al.   NATURE REVIEWS MICROBIOLOGY

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

(2011) Po-Ssu Huang et al.   PLoS One

Polar patterns of driven filaments

(2010) Volker Schaller et al.   NATURE

Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons

(2010) Wolfgang Wagner et al.   NATURE CELL BIOLOGY

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

A Novel Form of Motility in Filopodia Revealed by Imaging Myosin-X at the Single-Molecule Level

(2009) Michael L. Kerber et al.   CURRENT BIOLOGY

Engineered Myosin VI Motors Reveal Minimal Structural Determinants of Directionality and Processivity

(2009) Jung-Chi Liao et al.   JOURNAL OF MOLECULAR BIOLOGY

Unique charge distribution in surface loops confers high velocity on the fast motor protein Chara myosin

(2009) K. Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS