Article
Polymer Science
Honglei Zhang, Yanjuan Wu, Xiao Xu, Chen Chen, Xiukun Xue, Ben Xu, Tianduo Li, Zhaowei Chen
Summary: This study successfully developed a dual drug backbone polymeric nDDS for synergistic chemotherapy with cisplatin and curcumin, improving drug solubility and stability, and enhancing drug release.
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Article
Chemistry, Multidisciplinary
Dong-Bing Cheng, Xue-Hao Zhang, Si-Yi Chen, Xiao-Xue Xu, Hao Wang, Zeng-Ying Qiao
Summary: This paper presents an intracellular self-immolative polyprodrug (PMTO) that enhances cellular internalization and selective accumulation at tumor sites under mild hyperthermia triggered by laser irradiation. It also possesses the ability to monitor drug release in vivo. The polyprodrug amphiphiles are synthesized through esterification reactions, and poly(ethylene glycol) serves as a blocking agent. The PMTO nanoparticles release mitoxantrone (MTO) in the intracellular reductive environment and can be tracked using ratiometric photoacoustic imaging. The self-monitoring polyprodrug demonstrates significant tumor suppression efficacy and has potential for guiding clinical medication in cancer treatment.
ADVANCED MATERIALS
(2022)
Article
Oncology
Anthony D'Amico, Wanling Xie, Elizabeth McMahon, Marian Loffredo, Shana Medeiros, David Joseph, Jim Denham, Parvesh Kumar, Glenn Bubley, Molly Sullivan, Richard Hellwig, Juan Carlos Vera, Rolf Freter, W. Jeffrey Baker, Jeffrey Y. Wong, Andrew A. Renshaw, Philip W. Kantoff
Summary: Overall, adding docetaxel to ADT + RT did not prolong overall survival in men with unfavorable-risk prostate cancer, but it did decrease the incidence of RT-induced cancers. In the subgroup of men with a PSA < 4 ng/mL, the addition of docetaxel may prolong overall survival by reducing prostate cancer-specific mortality.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Polymer Science
Wenjia Zhang, Xiaoming Lyu, Li Zhang, Wenhui Wang, Qi Shen, Siyu Lu, Ligong Lu, Meixiao Zhan, Xianglong Hu
Summary: This study presents a label-free polyprodrug strategy to formulate doxorubicin nanoparticles, which can take advantage of the photophysical properties of the drug and achieve precise photothermal-chemotherapy.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qingye Meng, Hao Hu, Xiaodong Jing, Ying Sun, Liping Zhou, Yaowei Zhu, Bing Yu, Hailin Cong, Youqing Shen
Summary: Combination therapy using a reactive oxygen species (ROS)-responsive micelle loaded with dexamethasone (DEX) as a synergistic drug showed improved efficacy in releasing intact HCPT molecules in tumor cells. This co-delivery system demonstrated ideal tumor suppressive effects in both in vivo and in vitro settings. The modular multi-drug platform design provides a convenient strategy for future clinical treatment by selecting appropriate synergistic drugs according to the treatment plan.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Qinghao Zhou, Fathelrahman Mohammed, Yuheng Wang, Jingbo Wang, Nannan Lu, Junjie Li, Zhishen Ge
Summary: The study highlights the important influence of the inherent hypoxic microenvironment of solid tumors on tumor growth and spread. By preparing a polyprodrug, a complementary photodynamic-chemotherapy strategy can be achieved, effectively suppressing tumor growth through a combination of photodynamic therapy and chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Ji Luo, Shuguang Zhang, Peiyao Zhu, Wenke Liu, Jiang Du
Summary: In this study, pH/redox dual-responsive mixed polyprodrug micelles (MPPMs) were prepared for enhanced anticancer drug delivery. The MPPMs showed reasonable size and uniform dispersion, and exhibited pH and redox responsiveness. In vitro and in vivo experiments demonstrated that these MPPMs effectively released the drug and inhibited tumor growth, resulting in improved therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: This study evaluated the neurotoxic pathways of mitoxantrone in the brain of adult mice and found that it caused significant damage in regions associated with memory and cognition.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Oncology
Ivan de Kouchkovsky, Arpit Rao, Benedito A. Carneiro, Li Zhang, Catriona Lewis, Audrey Phone, Eric J. Small, Terence Friedlander, Lawrence Fong, Pamela L. Paris, Charles J. Ryan, Russell Z. Szmulewitz, Rahul Aggarwal
Summary: This study evaluated the safety and efficacy of ribociclib plus docetaxel in metastatic castration-resistant prostate cancer (mCRPC). The results showed that the combination treatment achieved a 6-month radiographic progression-free survival (rPFS) rate of 65.8% and a median rPFS of 8.1 months. Genomic profiling of circulating tumor cells (CTCs) suggested that nonamplified MYC was associated with longer rPFS.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemical Research Methods
Yanglan Gan, Xingyu Huang, Wenjing Guo, Cairong Yan, Guobing Zou
Summary: Combination therapy involving multiple drugs has emerged as an effective treatment for complex diseases like cancer. Deep learning models based on computational methods have proven to be valuable tools for predicting synergistic drug combinations. Despite challenges such as complexity, lack of biological interpretability, and discrepancies between in vivo and in vitro responses, DGSSynADR has been developed as a new method utilizing global structured features to predict effective anticancer drug combinations.
Article
Engineering, Biomedical
Kewei Wang, Xuan Xiao, Ye Liu, Qingyu Zong, Yalan Tu, Youyong Yuan
Summary: This study develops a nanosystem with self-amplifiable drug release pattern, which enhances the efficiency of chemotherapy drugs by specifically upregulating intratumoral ROS levels, resulting in significant antitumor efficacy.
Article
Nanoscience & Nanotechnology
Alexis M. Ziemba, Mary Clare Crochiere Woodson, Jessica L. Funnell, Douglas Wich, Bailey Balouch, Deniz Rende, Dahlia N. Amato, Jonathan Bao, Ingrid Oprea, Dominica Cao, Neda Bajalo, Evon S. Ereifej, Jeffrey R. Capadona, Edmund F. Palermo, Ryan J. Gilbert
Summary: Intracortical microelectrodes coated with a polyurethane copolymer of curcumin and PEG have been developed for brain-computer interfaces. The coating is soft and hydrophilic, with potential for long-term release of curcumin. In vivo experiments have shown that the coated electrodes are biocompatible and do not cause inflammation or damage to neurons.
ACS APPLIED BIO MATERIALS
(2023)
Article
Veterinary Sciences
Haylie C. Lawson, Margaret L. Musser, Rebecca Regan, Antony S. Moore, Ann Hohenhaus, Brian Flesner, Chad M. Johannes
Summary: Despite reports of chemotherapy overdoses in both human and veterinary medicine, overdoses of anthracyclines have been rare. This study aimed to describe the toxicities, treatments, and outcomes of dogs who experienced anthracycline overdoses. In a retrospective analysis of 16 cases, it was found that most overdoses were due to errors in chemotherapy preparation or dose calculation, leading to adverse events such as neutropenia, thrombocytopenia, anemia, diarrhea, anorexia, vomiting, lethargy, and nausea. High grade neutropenia was common and not improved by filgrastim administration. Supportive care was provided to all patients, and death was uncommon, highlighting the need for further evaluation of therapeutic guidelines for anthracycline overdoses.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zhihuai Chen, Xinqi Wei, Yunru Zheng, Zongwei Zhang, Wang Gu, Wenjun Liao, Hua Zhang, Xiaoying Wang, Jian Liu, Hua Li, Wei Xu
Summary: The molybdenum disulfide (MoS2)-based delivery system, functionalized with polyethylene glycol (PEG) and biotin, and co-loaded with curcumin (Cur) and erlotinib (Er), effectively converted near-infrared (NIR) light into heat, induced direct photothermal ablation of cancer cells, and promoted controlled release of Cur and Er. With the biotin-mediated tumor targeting, this system achieved the combination of synergistic chemotherapy and photothermal therapy (PTT), effectively suppressing lung cancer cell proliferation and inhibiting tumor growth in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-jie Tang, Qing-cong Kong, Zi-xuan Cheng, Yun-shi Liang, Zhe Jin, Lei-xin Chen, Wen-ke Hu, Ying-ying Liang, Xin-hua Wei, Yuan Guo, Xin-qing Jiang
Summary: This study investigated the effect of imaging features at different DCE-MRI phases on predicting TIL levels in breast cancer. Results showed that image features from delayed phase MRI had the best predictive performance, and the fusion multi-sequence radiomics model and combined radiomics-based clinical model performed the best in predicting TILs.
EUROPEAN RADIOLOGY
(2022)
Article
Engineering, Biomedical
Shiwei Luo, Di Ma, Ruili Wei, Wang Yao, Xinrui Pang, Ye Wang, Xiangdong Xu, Xinhua Wei, Yuan Guo, Xinqing Jiang, Youyong Yuan, Ruimeng Yang
Summary: Ferroptosis is a promising non-apoptotic regulated cell death form for cancer treatment. However, the efficacy of ferroptosis is limited by high glutathione levels and insufficient hydrogen peroxide levels in tumors. In this study, a theranostic nanoplatform was designed to enhance ferroptosis in the tumor microenvironment by releasing active components, and it was also used for tumor-specific magnetic resonance imaging, exhibiting high specificity and efficacy.
ACTA BIOMATERIALIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiwei Luo, Ruili Wei, Songlin Lu, Shengsheng Lai, Jialiang Wu, Zhe Wu, Xinrui Pang, Xinhua Wei, Xinqing Jiang, Xin Zhen, Ruimeng Yang
Summary: This study investigates the impact of different volume of interest (VOI) delineation strategies on machine learning-based predictive models for discrimination between low and high nuclear grade clear cell renal cell carcinoma (ccRCC) on dynamic contrast-enhanced CT. The findings suggest that radiomics features extracted from the unenhanced phase (UP) and excretory phase (EP) outperform features from other phases in differentiating high vs low nuclear grade ccRCC. Shape features and first-order statistics features showed superior discrimination ability.
EUROPEAN RADIOLOGY
(2022)
Article
Materials Science, Biomaterials
Wang Yao, Kewei Wang, Yuan Guo, Ruili Wei, Shiwei Luo, Wenjie Tang, Nianhua Wang, Chutong He, Xinhua Wei, Ruimeng Yang, Youyong Yuan, Xinqing Jiang
Summary: A multifunctional nanoplatform was designed to enhance the efficacy of photodynamic therapy (PDT) by using a GSH-responsive nitric oxide (NO) nano-prodrug that simultaneously depletes GSH and relieves hypoxia in tumors.
BIOMATERIALS ADVANCES
(2022)
Article
Oncology
Hongzhen Wu, Zihua Wang, Yingying Liang, Caihong Tan, Xinhua Wei, Wanli Zhang, Ruimeng Yang, Lei Mo, Xinqing Jiang
Summary: A nomogram incorporating clinical risk factors, blood indicators, and CT imaging findings was developed to predict the nature of FLLs in cirrhotic livers. The nomogram showed excellent discrimination and calibration for malignancy risk prediction, and it may aid in making FLLs treatment decisions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huikang Yang, Nianhua Wang, Ruimeng Yang, Liming Zhang, Xinqing Jiang
Summary: Folic acid-decorated reduction-sensitive star polymeric nanoparticles were synthesized and used for tumor-targeted MRI and chemotherapy. The nanoparticles efficiently delivered drugs and superparamagnetic iron oxide particles into tumor cells through folate receptor-mediated endocytosis and disulfide bond cleavage.
Article
Chemistry, Multidisciplinary
Yangyang Zhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan, Zhexiong Lian
Summary: In this study, CAR-T cells were engineered with HAase and alpha-PDL1 to improve their therapeutic effects on solid tumors. The modified CAR-T cells showed enhanced penetration into solid tumors, stronger antitumor activity, and no significant systemic side effects in animal models.
ACS CENTRAL SCIENCE
(2022)
Article
Engineering, Biomedical
Qingyu Zong, Jisi Li, Xuan Xiao, Xiaojiao Du, Youyong Yuan
Summary: This study presents a self-amplified chain-shattering polymer that selectively activates stimuli-responsive polymers in the tumor microenvironment for intelligent cancer therapy. The polymer is designed with ROS-responsive thioacetal and ROS-generating cinnamaldehyde, achieving self-amplified chain shattering for polymer degradation. The polymer can be modified with anticancer drug doxorubicin to amplify oxidative stress and immunogenic cell death of tumor cells, enhancing the effect of chemo-immunotherapy.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Biomaterials
Xue Hu, Jie Li, Yuhao Zhang, Menghua Xiong, Houbing Zhang, Youyong Yuan
Summary: In this study, a cationic helical oncolytic polypeptide (OLPP) with potent membranolytic activity was synthesized using ring-opening polymerization and thiol-ene reaction. The OLPP showed resistance to protease, high cytotoxicity to cancer cells, and induced cancer cell necrosis by lysing the cancer cell membrane independent of intracellular pathways. Intra-tumoral injection of the OLPP effectively suppressed tumor growth in mice, suggesting its potential as an oncolytic chemotherapeutic for cancer therapy.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Ye Liu, Maolin Jiang, Zhongyi Zhao, Nianhua Wang, Kewei Wang, Youyong Yuan
Summary: This study presents a smart nanoplatform CF@NDOX, which significantly up-regulates the expression of tumor-associated enzyme NQO1 through cyclic amplification of intracellular ROS, leading to efficient activation of the prodrug DOX and enhanced chemo-immunotherapy.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Zhongyi Zhao, Qingyu Zong, Jun Li, Maolin Jiang, Kewei Wang, Youyong Yuan
Summary: In this study, we combined low pH and cathepsin B dual-stimulus-triggered delivery carriers with a bioorthogonal reaction-activated prodrug to achieve regulated activation of the prodrug. The bioorthogonal reaction provides a feasible method for precise tumor therapy and imaging, by activating the prodrug and fluorescent probe.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jun Li, Qingyu Zong, Zhongyi Zhao, Youyong Yuan
Summary: In this study, a tumor-specific self-accelerating prodrug activation nanosystem was developed. It contains a self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH2, which has a reactive oxygen species dual-cycle amplification effect. Furthermore, the activated CyNH2 serves as a therapeutic agent with the potential to synergistically improve chemotherapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yansong Dong, Ye Liu, Yalan Tu, Youyong Yuan, Jun Wang
Summary: In this study, an activatable dual-modal probe is proposed that enhances near-infrared fluorescence intensity and magnetic resonance contrast through a tumor acidity-mediated click reaction. The probe was successfully activated and cross-linked in a mouse breast tumor, prolonging its retention and enhancing the bimodal signals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yansong Dong, Yalan Tu, Ye Liu, Maolin Jiang, Emil Bulatov, Youyong Yuan, Jun Wang
Summary: Anticancer nanomedicines can effectively aggregate around tumor blood vessels to create drug reservoirs for targeted drug delivery, improving therapeutic efficiency for cancer treatment.
