Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

(2020) Anupam Patgiri et al.   NATURE BIOTECHNOLOGY

Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease

(2019) Chi Fung Lee et al.   Scientific Reports

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

(2019) Isha H. Jain et al.   Cell Metabolism

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

(2019) Judith Giroud-Gerbetant et al.   Molecular Metabolism

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Leigh syndrome: One disorder, more than 75 monogenic causes

(2015) Nicole J. Lake et al.   ANNALS OF NEUROLOGY

Probing the structural dynamics of proteins and nucleic acids with optical tweezers

(2015) Dustin B Ritchie et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Leigh Syndrome

(2015) Nicole J. Lake et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study

(2015) Marcello Mancini et al.   PLoS One

Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery

(2014) K. J. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

PARP Inhibition Delays Progression of Mitochondrial Encephalopathy in Mice

(2014) Roberta Felici et al.   Neurotherapeutics

A multicenter study on Leigh syndrome: disease course and predictors of survival

(2014) Kalliopi Sofou et al.   Orphanet Journal of Rare Diseases

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Quantitative Measurement of Cerebral Oxygen Extraction Fraction Using MRI in Patients with MELAS

(2013) Lei Yu et al.   PLoS One

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain

(2012) Morten Overgaard et al.   FASEB JOURNAL

Fatal breathing dysfunction in a mouse model of Leigh syndrome

(2012) Albert Quintana et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I

(2012) Albert Quintana et al.   PLoS One

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

(2010) A. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral oxygen and glucose metabolism in patients with mitochondrial m.3243A>G mutation

(2009) Markus M. Lindroos et al.   BRAIN

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism