Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPARγ-Klotho-FoxO1 axis in diabetic nephropathy

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

(2019) Linlin Ji et al.   Oxidative Medicine and Cellular Longevity

Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells

(2019) Qi Wang et al.   CELL CYCLE

Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

(2019) Jianxia Ma et al.   Artificial Cells Nanomedicine and Biotechnology

Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy

(2019) Wei Jiang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model

(2018) Pin Chen et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Klotho Restraining Egr1/TLR4/mTOR Axis to Reducing the Expression of Fibrosis and Inflammatory Cytokines in High Glucose Cultured Rat Mesangial Cells

(2018) Can Wu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Role of Forkhead Box O (FOXO) transcription factor in aging and diseases

(2018) Neelam Tia et al.   GENE

Update of pathophysiology and management of diabetic kidney disease

(2018) Yi-Chih Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

(2018) Hans-Joachim Anders et al.   Nature Reviews Nephrology

The Klotho proteins in health and disease

(2018) Makoto Kuro-o   Nature Reviews Nephrology

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Chinese medicine for diabetic kidney disease in China

(2017) Yumin Wen et al.   NEPHROLOGY

Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

(2017) Hengjiang Guo et al.   Scientific Reports

Overexpression of FOXO1 ameliorates the podocyte epithelial–mesenchymal transition induced by high glucose in vitro and in vivo

(2016) Mengmeng Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of overexpressing FoxO1 on apoptosis in glomeruli of diabetic mice and in podocytes cultured in high glucose medium

(2016) Wen Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Podocytes: the Weakest Link in Diabetic Kidney Disease?

(2016) Jamie S. Lin et al.   Current Diabetes Reports

Diabetic nephropathy: where are we on the journey from pathophysiology to treatment?

(2016) H. Gallagher et al.   DIABETES OBESITY & METABOLISM

Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

(2016) Sang Soo Kim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

(2016) Ji-Hee Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6

(2016) XING-MEI YAO et al.   Molecular Medicine Reports

Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy

(2016) Hengjiang Guo et al.   Frontiers in Pharmacology

Effects of FoxO1 on podocyte injury in diabetic rats

(2015) Feng Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice

(2015) Hiroyuki Kadoya et al.   Clinical and Experimental Nephrology

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells

(2015) Feng Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats

(2015) Lina Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

New Insights into the PPARγAgonists for the Treatment of Diabetic Nephropathy

(2014) Zhanjun Jia et al.   PPAR Research

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Genetic Deficiency of Anti-Aging GeneKlothoExacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

(2013) Yi Lin et al.   ENDOCRINOLOGY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

(2012) Osamu Asai et al.   KIDNEY INTERNATIONAL

The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats

(2012) Lina Wu et al.   MOLECULAR BIOLOGY REPORTS

Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo

(2012) Dingkun Gui et al.   PLoS One

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats

(2010) Meng-Fu Cheng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PPARγ and chronic kidney disease

(2010) Agnes B. Fogo   PEDIATRIC NEPHROLOGY