Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism

Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

(2020) Marie-Camille Chaumais et al.   CARDIOVASCULAR RESEARCH

LCZ696 mitigates diabetic-induced nephropathy through inhibiting oxidative stress, NF-κB mediated inflammation and glomerulosclerosis in rats

(2020) Mohamed Mohany et al.   PeerJ

Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays

(2019) Nasrien E. Ibrahim et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Neurohormonal modulation: The new paradigm of pharmacological treatment of heart failure

(2019) J. Silva-Cardoso et al.   Revista Portuguesa de Cardiologia

Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure

(2019) Stine Andersen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pulmonary Arterial Hypertension Due to NPR-C Mutation: A Novel Paradigm for Normal and Pathologic Remodeling?

(2019) Emmanuel Eroume-A Egom   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator

(2019) Alice Huertas et al.   CARDIOVASCULAR RESEARCH

Treatment of Pulmonary Hypertension With Angiotensin II Receptor Blocker and Neprilysin Inhibitor Sacubitril/Valsartan

(2019) Richard T. Clements et al.   Circulation-Heart Failure

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

(2018) Yuichi Tamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

From ARB to ARNI in Cardiovascular Control

(2016) Estrellita Uijl et al.   CURRENT HYPERTENSION REPORTS

Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens

(2016) Michele Senni et al.   EUROPEAN JOURNAL OF HEART FAILURE

Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy

(2016) Javier Díez   EUROPEAN JOURNAL OF HEART FAILURE

Sacubitril/valsartan in heart failure: latest evidence and place in therapy

(2016) Edgardo Kaplinsky   Therapeutic Advances in Chronic Disease

Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension

(2015) B. A. Maron et al.   CIRCULATION

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Neprilysin and Renin-Angiotensin System Inhibition for the Treatment of Heart Failure

(2014) Orly Vardeny et al.   JACC-Heart Failure

Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension

(2012) Frances S. de Man et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase

(2011) Dachun Xu et al.   HYPERTENSION

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

(2009) Anderson J. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

(2008) Reshma S. Baliga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE