Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes

Mitochondrial hyperfusion: a friend or a foe

(2020) Rajdeep Das et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial Protection by PARP Inhibition

(2020) Ferenc Gallyas Jr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

(2020) Sergio Rius-Pérez et al.   Oxidative Medicine and Cellular Longevity

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

The Effects of Bradykinin B1 Receptor Antagonism on the Myocardial and Vascular Consequences of Hypertension in SHR Rats

(2019) Laszlo Deres et al.   Frontiers in Physiology

New perspectives and future directions in the treatment of heart failure

(2019) Pierpaolo Pellicori et al.   HEART FAILURE REVIEWS

Mitochondrial dynamics and their potential as a therapeutic target

(2019) B.N. Whitley et al.   MITOCHONDRION

Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease

(2018) Anne Jessica Roe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes

(2018) Alba Signes et al.   Essays in Biochemistry

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

Biomarkers for heart failure: small molecules with high clinical relevance

(2018) C. Magnussen et al.   JOURNAL OF INTERNAL MEDICINE

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

(2018) Qinhua Jin et al.   Redox Biology

Myocardial Remodeling in Hypertension

(2018) Arantxa González et al.   HYPERTENSION

PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

(2018) Antal Tapodi et al.   BIOCHEMICAL PHARMACOLOGY

Treating oxidative stress in heart failure: past, present and future

(2018) Atze van der Pol et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Transition From Hypertension to Heart Failure

(2017) Franz H. Messerli et al.   JACC-Heart Failure

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats

(2017) Krisztian Eros et al.   PLoS One

Global Disparities of Hypertension Prevalence and ControlClinical Perspective

(2016) Katherine T. Mills et al.   CIRCULATION

PARP inhibition and postinfarction myocardial remodeling

(2016) Robert Halmosi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats

(2014) Klara Magyar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms

(2014) Laszlo Deres et al.   PLoS One

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms of free radical-induced damage to DNA

(2012) Miral Dizdaroglu et al.   FREE RADICAL RESEARCH

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Pressure overload-induced mild cardiac hypertrophy reduces left ventricular transmural differences in mitochondrial respiratory chain activity and increases oxidative stress

(2012) Michel Kindo et al.   Frontiers in Physiology

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

New roles for mitochondria in cell death in the reperfused myocardium

(2011) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Cardiovascular Changes During Maturation and Ageing in Male and Female Spontaneously Hypertensive Rats

(2011) Vincent Chan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Regulation of Kinase Cascade Activation and Heat Shock Protein Expression by Poly(ADP-ribose) Polymerase Inhibition in Doxorubicin-induced Heart Failure

(2011) Eva Bartha et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: A new mechanism for the cytoplasmic effect of PARP-1 activation

(2010) Boglarka Racz et al.   FREE RADICAL BIOLOGY AND MEDICINE

PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats

(2009) E. Bartha et al.   CARDIOVASCULAR RESEARCH

Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue

(2009) Shigeki Miyamoto et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Effect of L-2286, a Poly(ADP-ribose)polymerase Inhibitor and Enalapril on Myocardial Remodeling and Heart Failure

(2008) Eva Bartha et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR

(2008) John G. Edwards   MITOCHONDRION