Review
Biochemistry & Molecular Biology
Marion Mueller, Elfi Donhauser, Tibor Maske, Cornelius Bischof, Daniel Dumitrescu, Volker Rudolph, Anna Klinke
Summary: In order to develop targeted therapies for the growing patient population with right ventricular dysfunction (RVD) and right heart failure (RHF), molecular processes underlying these conditions need to be understood. Mitochondrial dysfunction has been identified as a potential key player in the development of RHF, affecting mitochondrial biogenesis, substrate utilization, redox balance, and oxidative phosphorylation. This review aims to comprehensively analyze the current knowledge on mitochondrial dysregulation in RVD and RHF and its relationship with the functional aspects of the right ventricle (RV).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Gambardella, Stanislovas S. Jankauskas, Urna Kansakar, Fahimeh Varzideh, Roberta Avvisato, Nella Prevete, Simone Sidoli, Pasquale Mone, Xujun Wang, Angela Lombardi, Gaetano Santulli
Summary: This study conducted comprehensive in vivo and in vitro experiments to investigate the molecular processes underlying ischemic cardiac disease. The findings revealed a specific pattern of chromatin remodeling induced by ischemic injury, which led to the transcriptional repression of a key regulator of mitochondrial function. Additionally, the study discovered a novel pathway linking metabolism to gene expression, demonstrating the role of ketone bodies in modulating chromatin remodeling and mitochondrial dysfunction.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Gizem Keceli, Ashish Gupta, Joevin Sourdon, Refaat Gabr, Michael Schaer, Swati Dey, Carlo G. Tocchetti, Annina Stuber, Jacopo Agrimi, Yi Zhang, Michelle Leppo, Charles Steenbergen, Shenghan Lai, Lisa R. Yanek, Brian O'Rourke, Gary Gerstenblith, Paul A. Bottomley, Yibin Wang, Nazareno Paolocci, Robert G. Weiss
Summary: Abnormal energy metabolism in the heart is closely related to pathological remodeling in heart failure. Mitochondrial creatine kinase plays a critical role in attenuating maladaptive hypertrophy in heart failure by reducing reactive oxygen species levels and upregulating antioxidants.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Article
Medicine, Research & Experimental
Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Myocardial infarction (MI) is a leading cause of death worldwide, and oxidative stress, inflammation, and mitochondrial dysfunction are recognized as possible mechanisms in the development of MI. Different types of programmed cell death (PCDs), including apoptosis, necroptosis, ferroptosis, and pyroptosis, have been associated with different phases of ischemic injury following MI. However, it is still unknown which types of PCDs play the most dominant role in post-MI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Yan-Ni Su, Pei-Pei Lu, Si-Yu Yan, Xuan-Tong Guo, Jie Ma, Cai-Xia Guo, Li-Hong Ma
Summary: The study investigated the regulation of Xinfuli Granule (XG) on energy metabolism of heart failure (HF) with a focus on endoplasmic reticulum stress (ERS) and mitochondrial function. The results showed that XG improved cardiac metabolic remodeling and stimulated ATP production by increasing the expression of PGC1 alpha in HF rats. XG also helped restore mitochondrial deformation and reduce apoptosis rate in hypoxia-ischemia (H-I) H9c2 cells, potentially through inhibiting ERS-related proteins and the RHOA/ROCK pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Runran Miao, Libo Wang, Zhigang Chen, Shiqi Ge, Li Li, Kai Zhang, Yingen Chen, Wenjing Guo, Xulei Duan, Mingyang Zhu, Guoan Zhao, Fei Lin
Summary: Myocardial remodeling is the key pathophysiological basis of heart failure. Research has found that the NOXs play an important role in myocardial remodeling and their regulatory mechanisms may be promising therapeutic targets for the treatment of heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew Hoffman, Dimitra Palioura, Ioannis D. Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P. Christian Schulze, Ira J. Goldberg, Raj Kishore, Vincent W. Yang, Thomas D. Bannister, Agnieszka B. Bialkowska, Craig H. Selzman, Stavros G. Drakos, Konstantinos Drosatos
Summary: KLF5 is found to play a crucial role in the pathophysiology of ischemic heart failure, involving regulation of lipid metabolism. Genetic or pharmacological inhibition of KLF5 prevents ceramide accumulation, alleviates cardiac remodeling, and improves ejection fraction in mice with myocardial infarction.
Article
Cell Biology
Yajuan Ni, Jie Deng, Xin Liu, Qing Li, Juanli Zhang, Hongyuan Bai, Jingwen Zhang
Summary: Myocardial remodelling is a key pathological process in HF, and ECH reverses this process and improves cardiac function by regulating the SIRT1/FOXO3a/MnSOD axis and inhibiting mitochondrial oxidative stress.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Review
Pharmacology & Pharmacy
Chennan Wu, Zhen Zhang, Weidong Zhang, Xia Liu
Summary: Cardiovascular diseases, including heart failure, are leading causes of death globally. Despite advancements in therapies, life expectancy for heart failure remains poor. Targeting mitochondrial dysfunction, which is closely related to heart failure, may be an effective approach for treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Syed Baseeruddin Alvi, Divya Sridharan, Shridhar K. Sanghvi, Muhamad Mergaye, Uzair Ahmed, Sarah K. Mikula, Harpreet Singh, Mahmood Khan
Summary: This study demonstrates the potential of polydopamine nanoparticles (PDA-NPs) as a bioactive agent to enhance contractility and beat propagation of cardiomyocytes. PDA-NPs improve mitochondrial bioenergetics and have cardiotonic effects on the heart. In addition, they can modulate the genetic expression of cardiomyocytes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cardiac & Cardiovascular Systems
John W. Ostrominski, Muthiah Vaduganathan, Senthil Selvaraj, Brian L. Claggett, Zi Michael Miao, Akshay S. Desai, Pardeep S. Jhund, Mikhail N. Kosiborod, Carolyn S. P. Lam, Silvio E. Inzucchi, Felipe A. Martinez, Rudolf A. de Boer, Adrian F. Hernandez, Sanjiv J. Shah, Magnus Petersson, Anna Maria Langkilde, John J. V. Mcmurray, Scott D. Solomon
Summary: This study analyzed the potential role of dapagliflozin in treating apparent treatment-resistant hypertension (aTRH) in heart failure patients. The results showed that dapagliflozin consistently improved cardiovascular outcomes and was well-tolerated in patients with aTRH.
Article
Endocrinology & Metabolism
Rui Xu, Jing Fu, Yuting Hu, Xiaoyan Yang, Xiang Tao, Long Chen, Kai Huang, Qin Fu
Summary: Patients with type 2 diabetes have a high risk of developing cardiovascular disease. Dysregulation of phosphodiesterase 4 (PDE4) is of pathophysiological importance in metabolic disorders. Inhibition of PDE4 can reverse diabetic cardiac dysfunction caused by a high-fat diet, suggesting a therapeutic potential in preventing or treating cardiac dysfunction in diabetes.
Review
Cardiac & Cardiovascular Systems
Morris Karmazyn, Xiaohong Tracey Gan
Summary: Herbal-based medications, particularly ginseng and ginkgo, have been used for thousands of years in Asian cultures and have shown beneficial effects on the cardiovascular system. The bioactive components, such as ginsenosides in ginseng and ginkgolides in ginkgo, have been demonstrated to attenuate hypertrophy and remodeling in experimental models. These compounds share common effects, including antioxidant and antiapoptotic properties, as well as the inhibition of pro-hypertrophic intracellular signaling. Although robust clinical evidence is lacking, small trials have provided limited supporting evidence for the potential use of ginseng as adjuvant therapy for myocardial remodeling and heart failure.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Maja Bogdan, Ljilijana Peric, Katalin Ordog, Dubravka Vukovic, Edit Urban, Jozsef Soki
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2018)
Article
Immunology
Eszter Pakai, Valeria Tekus, Csaba Zsiboras, Zoltan Rumbus, Emoke Olah, Patrik Keringer, Nora Khidhir, Robert Matics, Laszlo Deres, Katalin Ordog, Nikolett Szentes, Krisztina Pohoczky, Agnes Kemeny, Peter Hegyi, Erika Pinter, Andras Garami
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell Biology
Orsolya Horvath, Katalin Ordog, Kitti Bruszt, Laszlo Deres, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Summary: BGP-15 treatment preserved cardiac function and reduced fibrosis, prevented cardiomyocyte hypertrophy, enhanced prosurvival signalling pathways, and promoted mitochondrial biogenesis in hypertensive animals with heart failure.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Orsolya Horvath, Katalin Ordog, Kitti Bruszt, Nikoletta Kalman, Dominika Kovacs, Balazs Radnai, Ferenc Gallyas, Kalman Toth, Robert Halmosi, Laszlo Deres
Summary: BGP-15 demonstrates protective effects on mitochondria by inhibiting fission, promoting fusion, preserving mitochondrial genome, and enhancing biogenesis. These effects help maintain mitochondrial function under oxidative stress induced by hydrogen peroxide and in an in vivo heart failure model, suggesting a novel therapeutic approach for heart failure.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.