TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury

(2018) Kim A.T. Verheijden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors

(2017) Zhongwei Qu et al.   JOURNAL OF NEUROCHEMISTRY

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ  -1) and profilin 2

(2016) R. Rollason et al.   BIOSCIENCE REPORTS

ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips

(2016) Susumu Tanimura et al.   JOURNAL OF CELL BIOLOGY

TRPC6 G757D Loss-of-Function Mutation Associates with FSGS

(2016) M. Riehle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury

(2016) Fangrui Ding et al.   PLoS One

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

(2015) T Maier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance

(2014) Xuefei Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice

(2014) Jiancheng Zhang et al.   NEUROSCIENCE

NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex

(2013) Eun Young Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol

(2013) Marc Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2)

(2013) David Chiluiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Pathobiology of focal segmental glomerulosclerosis

(2012) Vivette D. D’Agati   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1

(2012) Jessica J Harris et al.   JOURNAL OF PATHOLOGY

New players in the pathogenesis of focal segmental glomerulosclerosis

(2012) C. Schell et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Focal Segmental Glomerulosclerosis and Chronic Kidney Disease in Pediatric Patients

(2011) Jeremy Kiffel et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Over-expressing transient receptor potential cation channel 6 in podocytes induces cytoskeleton rearrangement through increases of intracellular Ca2+ and RhoA activation

(2011) Lina Jiang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Balancing Calcium Signals through TRPC5 and TRPC6 in Podocytes

(2011) A. Greka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tyrosine phosphorylation–dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis

(2011) Shoichiro Kanda et al.   MOLECULAR BIOLOGY OF THE CELL

The podocyte cytoskeleton—key to a functioning glomerulus in health and disease

(2011) Gavin I. Welsh et al.   Nature Reviews Nephrology

Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats

(2010) Wanlu Du et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of NFAT Signaling in Podocytes Causes Glomerulosclerosis

(2010) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription

(2009) Johannes Schlöndorff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis

(2009) S. Santin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

(2008) Laura Trinkle-Mulcahy et al.   JOURNAL OF CELL BIOLOGY