Review
Biochemistry & Molecular Biology
Michele Provenzano, Federica Maritati, Chiara Abenavoli, Claudia Bini, Valeria Corradetti, Gaetano La Manna, Giorgia Comai
Summary: Diabetic kidney disease is a major contributor to kidney failure and cardiovascular risk in diabetic patients. Developing novel biomarkers for predicting patient risk and treatment response is essential for improving care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Transplantation
Danilo Fliser, Christoph Wanner
Summary: Progressive chronic kidney disease in individuals with type 2 diabetes mellitus is a global public health issue with challenges in predicting the individual course of the disease progression. Patterns of progression in CKD patients include both linear and nonlinear trajectories of GFR loss, with kidney function potentially remaining stable for years in the elderly.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Saiqi Qi, Jie Song, Linjun Chen, Huachun Weng
Summary: This article addresses the important roles of m6A modification in kidney diseases and its molecular mechanisms. The m6A modification has been shown to regulate RNA expression through splicing, export, attenuation, and translation initiation efficiency. Understanding the impact of m6A modification in kidney diseases can provide valuable insights for diagnosis and clinical management.
MOLECULAR MEDICINE
(2023)
Review
Pediatrics
James D. Odum, Hector R. Wong, Natalja L. Stanski
Summary: Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill children, and current treatment options remain limited to prevention and supportive care. Biomarkers have been investigated to improve the prediction and diagnosis of SA-AKI, but have had variable success in pediatric sepsis.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Giulio Rivetti, Brenden E. Hursh, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Summary: Children with type 1 diabetes mellitus have an increased risk of kidney involvement, with some of the risk occurring at the beginning of the disease and the rest being related to poor glycemic control and the development of diabetic kidney disease.
PEDIATRIC NEPHROLOGY
(2023)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marya Morevati, Evandro Fei Fang, Maria L. Mace, Mehmet Kanbay, Eva Gravesen, Anders Nordholm, Soren Egstrand, Mads Hornum
Summary: This article reviews recent progress in the field of nicotinamide adenine dinucleotide (oxidized form, NAD(+)), mainly focusing on its role in acute kidney injury (AKI) and chronic kidney disease (CKD). While NAD(+) levels are reduced in AKI and conflicting results exist for CKD, increasing NAD(+) has been found beneficial for AKI. The article also discusses the compromised NAD(+) levels in renal fibrosis and senescence cells in the case of CKD. Further studies on NAD(+) in relation to AKI/CKD may provide insights for novel therapeutics, considering the urgent need for more effective treatments for patients with injured kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Stephen A. Smith, Paul E. Ronksley, Zhi Tan, Elijah Dixon, Brenda R. Hemmelgarn, W. Donald Buie, Neesh Pannu, Matthew T. James
Summary: This study found a strong association between ileostomy formation and subsequent kidney disease, leading to acute kidney injury and chronic kidney disease. Vigilance for this complication and new strategies for prevention and treatment are necessary.
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.
Article
Medicine, General & Internal
Lukasz Kuzma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Malgorzata Zalewska-Adamiec, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Marlena Kwiatkowska, Jolanta Malyszko
Summary: Patients with atrial fibrillation (AF) scheduled for coronary angiography are at higher risk of post-contrast acute kidney injury (PC-AKI), especially those with chronic kidney disease (CKD). This study found that kidney impairment was twice as common in AF patients undergoing coronary angiography, highlighting the need for extra caution in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Chih-Hsiang Chang, Shao-Wei Chen, Jia-Jin Chen, Yi-Hsin Chan, Chieh-Li Yen, Tao Han Lee, Yu-Ting Cheng
Summary: This study found that approximately one quarter of patients undergoing surgery for acute type A aortic dissection will develop AKD. Patients with AKD, with or without AKI, are at higher risk for MAKEs and readmission. Higher-stage AKD is associated with a trend of persistent decline in kidney function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Fengping Liu, Jiayi Sheng, Lei Hu, Bin Zhang, Wei Guo, Yang Wang, Yifeng Gu, Peng Jiang, Hao Lin, Brako Lydia, Yifan Sun, Yifan Tang, Chaoqun Gu, Shichao Wei, Qixiao Zhai, Weiguo Chen, Ninghan Feng
Summary: This study identifies distinct bacterial alterations in the oral microbiome of CKD patients and shows that bacterial dysbiosis in saliva plays a role in renal damage regardless of the occurrence of diabetes and hypertension.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Kam Wa Chan, Tak Yee Chow, Kam Yan Yu, Yibin Feng, Lixing Lao, Zhaoxiang Bian, Vivian Taam Wong, Sydney Chi-Wai Tang
Summary: This retrospective cohort study evaluates the effectiveness, safety profile, and prescription pattern of an integrative medicine service program for patients with diabetes and chronic kidney disease in Hong Kong. The results show that individualized add-on Chinese medicine treatment significantly preserves kidney function and is well tolerated.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Review
Medicine, General & Internal
Anna Faivre, Thomas Verissimo, Hannah Auwerx, David Legouis, Sophie de Seigneux
Summary: Acute and chronic kidney disease result in significant healthcare costs worldwide. Kidney metabolism undergoes profound changes during injury, potentially affecting fibrosis progression. Glucose metabolism may play a crucial role in both acute and chronic phases of renal disease.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Seth Winfree, Andrew T. McNutt, Suraj Khochare, Tyler J. Borgard, Daria Barwinska, Angela R. Sabo, Michael J. Ferkowicz, James C. Williams Jr, James E. Lingeman, Connor J. Gulbronson, Katherine J. Kelly, Timothy A. Sutton, Pierre C. Dagher, Michael T. Eadon, Kenneth W. Dunn, Tarek M. El-Achkar
Summary: The human kidney is a complex organ with various cell types. This study introduces new imaging modalities for studying the cellular makeup and spatial organization of the kidney. The VTEA software tool is developed for analyzing these complex imaging data sets and decoding the cellular and spatial complexity of the human kidney.
LABORATORY INVESTIGATION
(2023)
Article
Urology & Nephrology
George Vasquez-Rios, Wonsuk Oh, Samuel Lee, Pavan Bhatraju, Sherry G. Mansour, Dennis G. Moledina, Faris F. Gulamali, Edward D. Siew, Amit X. Garg, Pinaki Sarder, Vernon M. Chinchilli, James S. Kaufman, Chi-yuan Hsu, Kathleen D. Liu, Paul L. Kimmel, Alan S. Go, Mark M. Wurfel, Jonathan Himmelfarb, Chirag R. Parikh, Steven G. Coca, Girish N. Nadkarni
Summary: This study identified four subphenotypes of acute kidney injury (AKI) with different clinical features and biomarker profiles, which were associated with longitudinal clinical outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiguang Mao, Clare M. Miller, Venugopalan D. Nair, Yongchao Ge, Mary Anne S. Amper, Antonio Cappuccio, Mary-Catherine George, Carl W. Goforth, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Rachel S. G. Sealfon, Alessandra Soares-Schanoski, Sindhu Vangeti, Mital Vasoya, Dawn L. Weir, Elena Zaslavsky, Seunghee Biobank Team, Seunghee Kim-Schulze, Sacha Gnjatic, Miriam Merad, Andrew G. Letizia, Olga G. Troyanskaya, Stuart C. Sealfon, Maria Chikina
Summary: DNA methylation is a cumulative record of lifetime exposures and genetic markers. This study investigated the dynamics of blood epigenetic remodeling following asymptomatic and mildly symptomatic SARS-CoV-2 infection. Differential methylation persisted for months after infection and resembled autoimmune or inflammatory disease. Machine learning models based on methylation accurately distinguished different infection time periods and predicted time since infection. The clinical trajectory of young adults and a diverse cohort with severe outcomes was predicted based on the similarity of methylation before or early after SARS-CoV-2 infection to the postinfection state defined by the model. The postacute SARS-CoV-2 epigenetic landscape identified in this study is antiprotective.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Cell Biology
Camille Brewer, Tobias Lanz, Caryn R. Hale, Gregory D. Sepich-Poore, Cameron Martino, Austin D. Swafford, Thomas S. Carroll, Sarah Kongpachith, Lisa K. Blum, Serra E. Elliott, Nathalie E. Blachere, Salina Parveen, John Fak, Vicky Yao, Olga Troyanskaya, Mayu O. Frank, Michelle S. Bloom, Shaghayegh Jahanbani, Alejandro M. Gomez, Radhika Iyer, Nitya S. Ramadoss, Orr Sharpe, Sangeetha Chandrasekaran, Lindsay B. Kelmenson, Qian Wang, Heidi Wong, Holly L. Torres, Mark Wiesen, Dana T. Graves, Kevin D. Deane, V. Michael Holers, Rob Knight, Robert B. Darnell, William H. Robinson, Dana E. Orange
Summary: This study found that periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anticitrullinated protein antibodies (ACPAs), suggesting a link between oral mucosal inflammation and RA pathogenesis. The researchers also discovered that RA patients with periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of specific monocyte subsets observed in inflamed RA synovia and blood during RA flares. The bacteremia was caused by citrullinated oral bacteria and resulted in activation of ACPA B cells, promoting affinity maturation and epitope spreading to citrullinated human antigens.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yumeng Wen, Leyuan Xu, Isabel Melchinger, Heather Thiessen-Philbrook, Dennis G. Moledina, Steven G. Coca, Chi-yuan Hsu, Alan S. Go, Kathleen D. Liu, Edward D. Siew, T. Alp Ikizler, Vernon M. Chinchilli, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Lloyd G. Cantley, Chirag R. Parikh
Summary: Long-term injury and inflammation after acute kidney injury (AKI) may lead to chronic kidney disease (CKD) progression. Study on 656 AKI patients found that changes in urine biomarkers (KIM-1, MCP-1) and plasma biomarker (TNFR1) were associated with increased risk of CKD, while changes in urine uromodulin were associated with reduced risk of CKD. The trajectories of these biological processes were also associated with kidney atrophy in mice after ischemic reperfusion injury (IRI).
Article
Urology & Nephrology
Steven Menez, Yumeng Wen, Leyuan Xu, Dennis G. Moledina, Heather Thiessen-Philbrook, David Hu, Wassim Obeid, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, Kathleen D. Liu, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Steven G. Coca, Lloyd G. Cantley, Chirag R. Parikh
Summary: Urinary epidermal growth factor (EGF) may serve as a biomarker for tubular function and can be used to assess the risk of chronic kidney disease (CKD) after hospitalization. Higher urinary EGF concentrations three months post-discharge are associated with a reduced risk of major adverse kidney events (MAKE), such as CKD incidence, progression, or kidney failure.
KIDNEY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Victor Hugo Canela, William S. Bowen, Ricardo Melo Ferreira, Farooq Syed, James E. Lingeman, Angela R. Sabo, Daria Barwinska, Seth Winfree, Blue B. Lake, Ying-Hua Cheng, Joseph P. Gaut, Michael Ferkowicz, Kaice A. LaFavers, Kun Zhang, Fredric L. Coe, Elaine Worcester, Sanjay Jain, Michael T. Eadon, James C. Williams, Tarek M. El-Achkar
Summary: Kidney stone disease leads to significant morbidity and increased healthcare utilization. The authors have identified the spatial molecular landscape and specific pathways involved in stone-induced injury in the human renal papilla, and have identified associated urinary biomarkers.
NATURE COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Abinet M. Aklilu, Sanchit Kumar, Yu Yamamoto, Dennis G. Moledina, Frederick Sinha, Jeffrey M. Testani, F. Perry Wilson
Summary: SGLT2i exposure during acute kidney injury (AKI) among patients hospitalized with acute heart failure (AHF) was found to be safe and associated with decreased mortality and no delay in renal recovery. Prospective studies are needed to further investigate the effects of SGLT2i exposure during AKI, especially during heart failure hospitalizations.
Article
Medicine, Research & Experimental
Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh
Summary: In this study, urinary CXCL9 was identified as a diagnostic biomarker for acute tubulointerstitial nephritis (AIN) using urine proteomics. This finding was confirmed in multiple validation cohorts and higher expression of CXCL9 was observed in kidney biopsies from AIN patients. This discovery has important implications for the early diagnosis and treatment of AIN.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemical Research Methods
Zijun Zhang, Natalie Sauerwald, Antonio Cappuccio, Irene Ramos, Venugopalan D. Nair, German Nudelman, Elena Zaslavsky, Yongchao Ge, Angelo Gaitas, Hui Ren, Joel Brockman, Jennifer Geis, Naveen Ramalingam, David King, Micah T. McClain, Christopher W. Woods, Ricardo Henao, Thomas W. Burke, Ephraim L. Tsalik, Carl W. Goforth, Rhonda A. Lizewski, Stephen E. Lizewski, Dawn L. Weir, Andrew G. Letizia, Stuart C. Sealfon, Olga G. Troyanskaya
Summary: Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events have the potential to be better diagnostic biomarkers compared to gene expression. This study presents a computational framework for developing AS diagnostic biomarkers using SARS-CoV-2 infection data and identifies a major functional AS program switch upon viral infection. AS-based biomarkers are more accurate for SARS-CoV-2 diagnosis compared to transcriptome signatures, and microfluidic PCR diagnostic assays achieve nearly perfect test accuracy.
CELL REPORTS METHODS
(2023)
Meeting Abstract
Urology & Nephrology
Y. Diana Kwong, Kathleen Liu, Chi-Yuan Hsu, Bruce Cooper, Paul Palevsky, John Kellum, Kirsten Johansen, Christine Miaskowski
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medicine, Research & Experimental
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O'Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Summary: This study analyzed kidney biopsies from type 2 diabetes patients and healthy controls, and found that SGLT2 inhibitor treatment mitigates diabetes-induced metabolic perturbations through suppression of the mTORC1 signaling pathway in kidney tubules. The treatment with SGLT2 inhibitors also affected transcriptional processes in different segments of the renal tubules.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Critical Care Medicine
Claudio Ronco, Lakhmir Chawla, Faeq Husain-Syed, John A. Kellum
Summary: Sepsis and septic shock are still major causes of morbidity and mortality in critically ill patients. The clinical manifestation of these syndromes involves several steps, including microbial invasion, infection establishment, immune response, inflammation, tissue damage, organ dysfunction, and organ crosstalk. Different extracorporeal therapies can be used at different stages to target specific molecules or provide organ support. However, the success of these therapies may need to be evaluated using endpoints other than mortality.
Review
Biochemistry & Molecular Biology
Debra M. Foster, John A. Kellum
Summary: Endotoxin, also known as lipopolysaccharide (LPS), induces inflammatory response and can lead to sepsis and septic shock. Quantifying endotoxin and removing it using extracorporeal methods may be beneficial for patients with endotoxic septic shock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Alton B. Farris, Mariam P. Alexander, Ulysses G. J. Balis, Laura Barisoni, Peter Boor, Roman D. Bulow, Lynn D. Cornell, Anthony J. Demetris, Evan Farkash, Meyke Hermsen, Julien Hogan, Renate Kain, Jesper Kers, Jun Kong, Richard M. Levenson, Alexandre Loupy, Maarten Naesens, Pinaki Sarder, John E. Tomaszewski, Jeroen van der Laak, Dominique van Midden, Yukako Yagi, Kim Solez
Summary: The Banff Digital Pathology Working Group aims to establish a digital pathology repository and promote collaborations through the development, validation, and sharing of image analysis models, as well as regular videoconferencing. AI-based support systems for transplantation pathology were presented during the discussions, and potential collaborations in competitions/trials on AI applied to kidney transplant specimens were also discussed.
TRANSPLANT INTERNATIONAL
(2023)
