LGR4 silence aggravates ischemic injury by modulating mitochondrial function and oxidative stress via ERK signaling pathway in H9c2 cells

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

(2020) Jin Wang et al.   Acta Pharmaceutica Sinica B

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

(2020) Gerd Heusch   Nature Reviews Cardiology

Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells

(2020) Fang Liang et al.   LIFE SCIENCES

Mitochondria "THE" target of myocardial conditioning

(2018) Kerstin Boengler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin

(2018) Shiying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LGR4 protects hepatocytes from injury in mouse

(2018) Ziru Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway

(2017) Zhongcheng Ke et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Myocardial Ischemia

(2016) Gerd Heusch   CIRCULATION RESEARCH

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway

(2016) Jianwei Zhang et al.   EXPERIMENTAL CELL RESEARCH

Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling

(2016) Ran Xu et al.   PEPTIDES

Effects of liraglutide on left ventricular function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

(2015) Wei Ren Chen et al.   AMERICAN HEART JOURNAL

Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling

(2015) Liming Yu et al.   APOPTOSIS

RNA-Seq identifies novel myocardial gene expression signatures of heart failure

(2015) Yichuan Liu et al.   GENOMICS

Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation

(2015) Jun Zhu et al.   PLoS One

Lgr4Gene Regulates Corpus Luteum Maturation Through Modulation of the WNT-Mediated EGFR-ERK Signaling Pathway

(2014) Hongjie Pan et al.   ENDOCRINOLOGY

Lgr4Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice

(2013) Shijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression

(2013) Bing Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

(2013) Feng Wang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

(2011) Shoji Sanada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy

(2010) Aslan T. Turer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes

(2010) Erinne R. Dabkowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation

(2010) Zhenlian Wang et al.   FEBS LETTERS

Endogenous Activation of Mitochondrial K ATP Channels Protects Human Failing Myocardium From Hydroxyl Radical–Induced Stunning

(2009) Christoph Maack et al.   CIRCULATION RESEARCH