DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction

Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway

(2020) Junzhi Li et al.   BIOSCIENCE REPORTS

α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation

(2019) Jun-zhou Xin et al.   ACTA PHARMACOLOGICA SINICA

Semisynthetic bile acids: a new therapeutic option for metabolic syndrome

(2019) Slavica Lazarević et al.   PHARMACOLOGICAL RESEARCH

Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction

(2018) Yunlong Xia et al.   CARDIOVASCULAR RESEARCH

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

(2018) Joaquim Miguel Vieira et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiota derived metabolites in cardiovascular health and disease

(2018) Zeneng Wang et al.   Protein & Cell

TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice

(2018) Zeena Eblimit et al.   Cardiovascular Therapeutics

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

(2018) Adriana Carino et al.   FASEB JOURNAL

Evidence of functional bile acid signaling pathways in adipocytes

(2018) Andreas Schmid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice

(2017) Jianshu Gao et al.   Molecular Medicine Reports

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

(2017) Paul M. Ryan et al.   Diabetology & Metabolic Syndrome

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice

(2016) Ajay C. Donepudi et al.   HEPATOLOGY

Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease

(2016) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes

(2015) Hongliang Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype

(2014) Klemens Högenauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

The inflammatory response in myocardial injury, repair and remodelling

(2014) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury

(2012) Jun Pu et al.   EUROPEAN HEART JOURNAL

Ursodeoxycholic Acid in Patients With Chronic Heart Failure

(2012) Stephan von Haehling et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Third Universal Definition of Myocardial Infarction

(2012) Kristian Thygesen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Cyclic AMP: a selective modulator of NF-κB action

(2011) Sarah Gerlo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isorhamnetin inhibits H2O2-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation

(2011) Bing Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism