Article
Oncology
Zi-liang Yang, Xu-qi Sun, Yu-hao Tang, Pei-yao Xiong, Li Xu
Summary: Liver resection (LR) remains the best choice for AJCC stage I hepatocellular carcinoma (HCC) patients, regardless of tumor size. For HCC ≤ 2 cm, stereotactic body radiation therapy (SBRT) can be an alternative treatment to radiofrequency ablation (RFA). For HCC > 2 cm, RFA provides better long-term survival than SBRT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Huimei Zhang, Na Chang, Tiantian Han, Shaodi Ma, Guangbo Qu, Haixia Liu, Chenyu Sun, Ce Cheng, Qin Zhou, Yehuan Sun
Summary: This meta-analysis compared the efficacy of RFA and SBRT in treating HCC patients, finding that RFA had better outcomes in terms of improving survival rates and reducing local disease progression, whereas SBRT achieved superior local control of tumor tissues.
Article
Oncology
Feiqian Wang, Kazushi Numata, Atsuya Takeda, Katsuaki Ogushi, Hiroyuki Fukuda, Hiromi Nihonmatsu, Koji Hara, Makoto Chuma, Yuichirou Tsurugai, Shin Maeda
Summary: RFA and SBRT treatment may be potential options for patients with multifocal HCC in BCLC stage A4-B1 due to favorable prognosis and safety. Prospective, controlled, large-scale studies are needed to further confirm these conclusions before clinical application.
Article
Gastroenterology & Hepatology
Hwang Sik Shin, Sae Hwan Lee, Baek Gyu Jun, Hong Soo Kim, Seong Hee Kang, Ji Young Park, Soo In Choi, Gab Jin Cheon, Young Don Kim, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim, Soung Won Jeong, Jae Young Jang, Ki Tae Suk, Dong Joon Kim, In Young Jo, Yong Kyun Won
Summary: This study compared the therapeutic effects of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in patients with small hepatocellular carcinomas (HCCs), and found no significant differences in overall survival and local control rates between the two treatment methods.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Oncology
Aleena Malik, Meghan P. Jairam, Ronald Chow, Seyed A. Mirshahvalad, Patrick Veit-Haibach, Charles B. Simone II
Summary: The aim of this meta-regression was to assess the impact of age, tumor size, percentage of males, and total sample size on the comparative effectiveness of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT). Ten studies reporting on overall survival and local control were included. Age showed a significant relationship with overall survival and local control for both RFA and SBRT, while tumor size had no significant relationship with overall survival or local control by SBRT.
Review
Surgery
Seong Wook Shin, Keun Soo Ahn, Sang Woo Kim, Tae-Seok Kim, Yong Hoon Kim, Koo Jeong Kang
Summary: This study found that liver resection (LR) is more effective than local ablation therapies (such as RFA, MWA, and RFA plus TACE) in treating HCC within the Milan criteria. Specifically, LR has better 5-year recurrence-free survival and lower local recurrence rates compared to local ablation therapies.
Review
Gastroenterology & Hepatology
Jiawei Hong, Linping Cao, Haiyang Xie, Yuanxing Liu, Jun Yu, Shusen Zheng
Summary: This study found that small HCC patients treated with SBRT had a significantly lower 2-year overall survival rate compared to those treated with RFA, but a higher rate of local progression within 2 years. There was no significant difference in the local and liver toxicities between the two treatments.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Melanie A. Kimm, Sophia Kaestle, Matthias M. R. Stechele, Elif Oecal, Lisa Richter, Muzaffer R. Uemuetlue, Regina Schinner, Osman Oecal, Lukas Salvermoser, Marianna Alunni-Fabbroni, Max Seidensticker, S. Nahum Goldberg, Jens Ricke, Moritz Wildgruber
Summary: This study found that local ablative therapies may have systemic effects on circulating immune cells in HCC patients. The levels of mMDSCs increased in almost all patients following local ablation, and there were varying alterations in monocyte subpopulations depending on the type of ablation. Liquid biopsy of circulating monocytes may provide information on the inflammatory response and immune reaction following local ablation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Hong Jae Jeon, Hyuk Soo Eun, In Sun Kwon, Byung Seok Lee, Eaum Seok Lee, Woo Sun Rou, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seok-Hwan Kim, Kwangsik Chun, Seok Hyun Kim
Summary: This study compared the therapeutic outcomes of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in patients with hepatocellular carcinoma (HCC). The results revealed that LRFA was associated with longer recurrence-free survival and favorable overall survival compared to PRFA. Therefore, LRFA should be considered as the primary therapy for eligible HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Sooyeon Kim, Jungsue Lee, Chai Hong Rim
Summary: This meta-analysis investigates the benefits of local treatment for oligometastasis in hepatocellular carcinoma (HCC) and finds that it significantly improves survival rates and outcomes.
Article
Oncology
Ming Li, Xiao Xu, Yingyi Qin, Peng Zhang, Changxing Shen, Qing Xia, Lihong Fan
Summary: Comparing the effectiveness of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in patients with stage IA non-small cell lung cancer (NSCLC) who were ineligible for surgery, it was found that RFA did not adversely affect the overall and cancer-specific survival of patients. In fact, RFA seemed to offer better survival, especially for patients with smaller tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
Review
Biology
Chai Hong Rim, Hye Yoon Lee, Jung Sun Kim, Hakyoung Kim
Summary: Both radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) have demonstrated efficacy in treating early hepatocellular carcinoma (HCC), but their effectiveness has yet to be compared in randomized studies. Research has described the characteristics and indications of both treatment modalities and discussed recent comparative studies between them.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jungnam Lee, Young-Joo Jin, Seung Kak Shin, Jung Hyun Kwon, Sang Gyune Kim, Young Ju Suh, Yujin Jeong, Jung Hwan Yu, Jin-Woo Lee, Oh Sang Kwon, Soon Woo Nahm, Young Seok Kim
Summary: This study compared the efficacy of surgical resection and radiofrequency ablation in CTP A and single small (<= 3 cm) HCC patients. The results showed that surgical resection had better recurrence-free survival in patients without cirrhosis. Therefore, the presence of cirrhosis should be considered when choosing the treatment method.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jonggi Choi, Nabihah Tayob, Young-Suk Lim
Summary: This study evaluated the performance of the parametric empirical Bayes (PEB) longitudinal AFP screening algorithm in patients with hepatitis B compared to AFP surveillance with a fixed threshold. The results showed that the PEB algorithm improved the accuracy of hepatocellular carcinoma (HCC) screening in patients with hepatitis B compared to AFP alone, without additional cost or inconvenience to patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jiwon Yang, Won-Mook Choi, Ju Hyun Shim, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: The long-term outcomes of untreated patients with compensated cirrhosis and low-level viremia were compared in this study. It was found that patients with low-level viremia had a significantly higher risk of hepatocellular carcinoma compared to those with undetectable HBV DNA. Therefore, antiviral treatment should be recommended for these patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Jonggi Choi, Young-Suk Lim, Ji-Hoon Kim, Kwan Soo Byun, Byung Chul Yoo
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, W. Ray Kim, Leland J. Yee, Craig Brooks-Rooney, Tristan Curteis, Harriet Cant, Chien-Hung Chen, Chi-Yi Chen, Yi-Hsiang Huang, Young-Joo Jin, Dae Won Jun, Jin-Woo Kim, Neung Hwa Park, Cheng-Yuan Peng, Hyun Phil Shin, Woo Shin, Yao-Hsu Yang, Young-Suk Lim
Summary: This study compared the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients receiving tenofovir disoproxil fumarate (TDF) versus entecavir (ETV) treatment. The results showed that patients receiving TDF had a significantly lower HCC risk, especially those with HBeAg positivity.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Young-Suk Lim
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Scott K. Fung, Calvin Q. Pan, Grace Lai-Hung Wong, Wai-Kay Seto, Sang Hoon Ahn, Chi-Yi Chen, Hie-Won L. Hann, Maciej S. Jablkowski, Yoon Jun Kim, Cihan Yurdaydin, Cheng-Yuan Peng, Tuan Nguyen, Hiroshi Yatsuhashi, John F. Flaherty, Leland J. Yee, Frida Abramov, Hongyuan Wang, Dzhamal Abdurakhmanov, Young-Suk Lim, Maria Buti
Summary: Patients with CHB who switch from TDF to TAF show changes in lipid profiles but no significant impact on cardiovascular risk.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Seo Yeon Yoo, Jong-In Chang, Seungbong Han, Young Seok Kim, Dong Hyun Sinn, Sang Hyun Choi, Dong Il Gwon, Young-Suk Lim
Summary: This study aimed to develop and validate a prognostic model for identifying patients with a risk of poor short-term survival after PSSE. Results showed that baseline levels of serum albumin, total bilirubin, and international normalized ratio were significantly associated with 1-year overall survival after PSSE. The ABI score, developed based on these factors, showed good discrimination performance in predicting 3-month and 6-month survival.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Dongsub Jeon, Hye Ryeong Cha, Sung Won Chung, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Seung Won Lee, Won-Mook Choi
Summary: This study investigated the effect of statin use on the prognosis of hepatocellular carcinoma (HCC) patients after hepatic resection. Data from nationwide and hospital cohorts in Korea were analyzed. The findings suggest that statin use is associated with a better prognosis, with improved recurrence-free survival and overall survival. This association is particularly significant in non-cirrhotic patients, tumors larger than or equal to 3 cm, tumors with microscopic vascular invasion, or early HCC recurrence.
Meeting Abstract
Gastroenterology & Hepatology
Seng Gee Lim, Man-Fung Yuen, Cristina Pojoga, Harry L. Janssen, Robert Plesniak, Keiji Tsuji, Ewa Janczewska, Corneliu Petru Popescu, Pietro Andreone, Jinlin Hou, Manuela Arbune, Diana Stefanova-Petrova, Jun Inoue, Teerha Piratvisuth, Young-Suk Lim, Apinya Leerapun, Masanori Atsukawa, Jidong Jia, Madalinee Eternity Labio, Jennifer Cremer, Robert Elston, Tamara Lukic, Geoffrey Quinn, Stuart Kendrick, Helene Plein, Fiona Campbell, Melanie Paff, Dickens Theodore
Meeting Abstract
Gastroenterology & Hepatology
Kanghee Park, Euichang Kim, Ji Won Yang, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Maria Buti, Kosh Agarwal, Henry Ly Chan, Wai-Kay Seto, Young-Suk Lim, Maurizia Brunetto, Wan-Long Chuang, Harry Janssen, Scott Fung, Namiki Izumi, Maciej Jablkowski, Frida Abramov, Hongyuan Wang, Leland Yee, Roberto Mateo, John F. Flaherty, Calvin Pan, Shalimar, Patrick Marcellin, Edward J. Gane
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jonggi Choi, Eunju Kim, Won-Mook Choi, Danbi Lee, Kang Mo Kim, Ju Hyun Shim, Young-Suk Lim, Han Chu Lee
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Tom Evans, Eleanor Barnes, Reena Mehta, Louise Bussey, Katie Anderson, Antonella Vardeu, Anthony Brown, Young-Suk Lim, Wan-Long Chuang, Chiyi Chen, Won Young Tak, Gin-Ho Lo
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Edward J. Gane, Alina Jucov, Marta Dobryanksa, Ki Tae Yoon, Tien Huey Lim, Andre Arizpe, Daniel Cloutier, Michael Chattergoon, Shenghua Mao, Sneha V. Gupta, Gregory Camus, Carey Hwang, Young-Suk Lim
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Hyeyeon Hong, Jonggi Choi, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee
JOURNAL OF HEPATOLOGY
(2023)